Complementary and alternative medicine (CAM) is making waves all over the world nowadays. The National Institute of Health started an office of alternative medicine in 1992 and established the National Center for CAM (NCCAM) in 1998. The annual budget has increased to 113.3 million dollars. The NCCAM has founded the Office of International Alternative Medicine (OIHR), to support collaborative work with countries other than USA. In 2003, 10 international planning grants were awarded which included a collaboration with Keio University in Japan.
In most of Asian countries except for Japan, the government supports promotion of its own traditional medicines. When European medicine came from Holland to Japan, in the Edo period, Japanese doctors quickly adopted European ways and mixed them with traditional Kampo medicine. For example, Seishu Hanaoka combined surgery with Kampo, for the benefit of his patients.
Taro Takemi pointed out Kampo drugs should be used in Kampo ways, and not in western medical ways. To globalize Kampo, first of all, Kampo should be more visible both in Japan and in the world. Secondly, the government's support is essential. Thirdly, public enlightenment concerning Kampo is necessary. Many people actually confuse Kampo, with dietary supplements. Fourthly, we need faculty members in universities, who can introduce Kampo as a part of Japan's medical culture. Lastly, Japan should contribute more to the development of traditional medicine in Asia.
Kampo is a definitive model of integrative medicine in our world. We must introduce this traditional heritage and treasure, globally.

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With the world standardization of inhaled steroids for bronchial asthma, the principle of Kampo medicine has changed from treatment for asthma attack to the prevention of it. The number of severe adult patient cases has decreased, and the number of hojinzai (kidney tonic) users has increased. The number of weaker children has increased, and the number of hohizai (spleen tonic) users has increased. Kampo medicine was not equal to inhaled steroids for the treatment of bronchial asthma, because the number of patients treated with Kampo medicine, having more than one year without an attack, was only 10% to 20%, and this figure would be lower, with inhaled steroids.
Nevertheless, Kampo medicine has had a great effect, on patients with milder symptoms, who do not require inhaled steroids, and well as those patients uncontrollable even with inhaled steroids. The Saiboku-to and Maozai groups, including Sho-sei-ryu-to and Ma-kyo-kan-seki-to, are good for milder patients. It is advisable to first check the immediate reaction of Maozai group users, following its administration in the clinic for treating attacks. The Hojinzai group, including Hachimi-jio-gan and Bakumi-jio-gan-ryo, are good for patients with the severe asthma or chronic obstructive pulmonary disease. An increase in the peak-flow rate of these patients with Hachimi-jio-gan might be related to activation of dehydroepiandrosterone, although the mechanism is unknown. Moku-boi-to is indicated for those patients with complicated heart failure.

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We evaluated the effect of Kampo therapy in which Kampo formulae were selected based on Japanese traditional theory, on the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related chronic liver disease. One hundred forty HCV-infected outpatients without HCC at their first examination and who were observed for more than one year, were included. The patients were divided into three groups according to the initial platelet count (Plt): Plt less than 10×10⁴/μL (Group I), Plt between 10×10⁴/μL and 14×10⁴/μL (Group II), and Pit greater than 14×10⁴/μL (Group III). For each patient, Kampo formulae were selected according to the patient's symptoms and physical findings at each clinic visit. The incidence of HCC calculated by the person-years method, was 0.89% in Group I. 1.55% in Group II and 0.29% in Group III. The annual incidence of HCC among our patients was low compared with that among untreated patients in previous reports. In addition, the incidence of HCC among our patients was low compared with that of previous studies where Shosaikoto or Juzentaihoto was administered for a long period of time. In the present study, age over 60 years was a possible risk factor for HCC. However, sex and patterns of the change in alanine aminotransferase level (ALT) were not associated with the development of HCC. A total of 53 different Kampo formulae were prescribed, for all patients, with Hochuekkito being the most frequent. These results suggest that Kampo treatment in which Kampo formulae are selected based on traditional theory, may be more useful than treatment by a single Kampo formula for preventing the development of HCC in patients with HCV-related chronic liver disease.

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We developed a new electrothermo-acupuncture instrument which employs a curved heating plate, and we compared this new one and the old hitherto used electrothermo-acupuncture instrument in terms of radiation temperature, using two male volunteers. The results showed that the 2nd step in the old instrument equaled the fifth channel in the new one. The radiation temperature increase of 140°C seen in 10 minutes was the same, between the two instruments, but the old one continued to increase its temperature, whereas the new one held at a plateau of about 140°C. Therefore, we considered that the new electrothermo-acupuncture instrument is safer than old one.
Next, we investigated the relation between effective Kampo formulas and endurance time in the fifth channel of the new electrothermo-acupuncture instrument, in nineteen patients. We found that Kampo formulas used in the resistant phase of Yang-syndrome disease, is effective in less than 10 minutes of endurance time, and the Kampo formula containing Aconite Tuber is effective for over 30 minutes.
We considered, because of the relation between endurance time and Kampo diagnosis, that the new electrothermo-acupuncture instrument can be useful in a supplementary way in deciding Kampo diagnosis.

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We report a case of rheumatoid arthritis (RA) that was successfully treated with Kei-kyo-so-so-o-shinbu-to. A 56-year-old woman had been receiving treatment in our department for RA since 1992, and polyarthralgia and multi-joint swelling had become exacerbated from the beginning of April 2003. C-reactive protein and erythrocyte sedimentation rate were elevated. She was hospitalized on_??_, but even with some Kampo formulas, these levels did not improve. The epigastric region was extended and appeared to be in a state of “Hotori-senpai” from _??_, and the administration of Kei-kyo-so-so-o-shinbu-to was begun on _??_. From the next day, pain, swelling of joints, and the “Hotori-senpai” status began to improve, as did the inflammatory reactions. Thus, it was considered, when Kei-kyo-so-so-o-shinbu-to was prescribed, focusing on the “Hotori-senpai”, “Ki-bun” and “Sui-in” status of this patient, that this prescription exerted immediate favorable effects.

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