The antigenic structures of Corynebacterium including C. diphtheriae and others were studied by agglutination reaction and it was confirmed that the strains so far tested contained heat-labile and Oinagglutinable antigen and heatstable antigen. The heat-labile antigen was rather type-specific and strainspecific and heat-stable antigen was cross-reacting to almost all of the tested strains including C. belfanti, C. hofmannii, C. xerosis, and C. ulcerans.
In this connection the experimental allergic reaction of guinea pig was investigated and it was confirmed that heat-stable antigen other than toxoid could be responsible for the allergic reaction to the crude toxoid in the market, but it did not sensitize the guinea pig against the purified diphtheria toxoid in the purity of 3300 Lf per mg. P. N.
And it was confirmed that the guinea pig could be sensitized against the diphtheria toxoid in the purity of 3300 Lf per mg. P. N.

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A study was made mainly from the epidemiological standpoint on infectious hepatitis which had been prevalent among inhabitants of Obatake village, Yamaguchi prefecture for about five years from 1965 to 1969.
Through a survey conducted in 1967 by The Yanai Public Health Center by means of questionnaires concerning hepatitis, it was made clear that the epidemic began in 1965 and the prevalent areas were found restricted to two districts of that village.
In 1969, another survey was carried out by the village authority in cooperation with the welfare department of Yamaguchi prefecture, The Yanai Public Health Center and some Doctors' associations. In this survey, about three hundred persons in the village were selected at random and examined for. the medical history, the status presens and the liver function. Of them, about 30 cases were put under the suspicion of liver diseases and subjected to the detailed revaluation at The Iwakuni National Hospital.
Aside from the surveys aforementioned, thirty seven cases in the village were hospitalized under the diagnosis of infectious hepatitis to The Iwakuni National Hospital from 1965 to Sept., 1969.All the data obtained were summarized as follows:
1) New outbreak of infectious hepatitis has not been seen for a considerable time and the epidemic is regarded to be over already.
Some cases were found to have relapsed to the chronic stage. No evidence of liver cirrhosis has ever been indicated in any case.
2) Adults were predominant and persons under 20 were rare in age distribution in morbidity. Male was predominant.
3) No particular seasonal preference was observed in morbidity in 1966 and 1967, but summer was found favorite in 1968 and 1969.
4) Familial occurrence was recognized in aboud 25% of all investigated.
5) In clinical pictures, no particular unusualness could be seen except for slight prolongation of preicteric stage in average. The rate of manifestation of jaundice was about 60%.
6) Infectious root of the epidemic could not be clarified, but the mode of infections was supposed to be of chain-type rather than of common-vehicle-type.

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One handred and twenty three strains of Pseudomonas aeruginosa (Ps. aerug.) isolated from clinical materials in the Hokkaido University Hospital in 1967 were typed serologically by means of Homma's agglutination method, utilizing a routine set of 12 standard sera. One handred and one strains (82.1%) were typable with an occurrence of type T5 in 36 strains (29.3%), type T8 in 23 (18.7%), type T3 in 9 (7.3%), and Type T1 and T4 each in 7 (5.7%).
Strains of Ps. aerug. were highly resistant to usual antibiotics such as tetracycline, chloramphenicol, streptomycin, kanamycin and carbenicillin with minimum growth inhibitory concentrations (MIC) of more than 50 mcg/ml. The mode of MIC of gentamicin, colistin and polymyxin B were 3.2, 6.3 and 3.2 mcg/ml respectively, which appeared to be within levels of therapeutic efficacy.
The type T5 strains were generally more resistant to the above mentioned eight antibiotics tested, and the type T8 strains were less resistant than all other strains. On the other hand, strains derived from urine samples were more resistant than those from any other sources. The incidence of urine derived strains in type T5 was higher (50%) than that in type T8 (17%). This may be one of the reasons for the higher antibiotic resistance of type T5 strains.

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米国教育厚生省 (Department of Health, Education, and Welfare) の定期刊行物に, National Communicable Disease Center (NCDC) から“Morbidity and Mortality Weekiy Report”(MMWR) という週刊パンフレットが発行されています.内容は合衆国の届出伝染病の週間州別発生速報が主ですがほかに各種感染症の集団発生報告や調査記録なども載つています.その中から興味ありそうな記事を選んで抄録しましよう.

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