FTA-ABS and TPHA, especially their specificity and sensitivity as a serum reaction of syphilis, were studied comparing with cardiolipin reaction, using 217 sera samples from patients with syphilis (21 primary syphilis 172 late latent s., and 24 congenital s.). The results were summarized as follows:
1) Sera of primary and congenital s. showed 100% positivity either by FTA-ABS or TPHA, while those of late latent s. were positive in 97.7% with FTA-ABS, in 94.2% with TPHA.
2) Results with FTA-ABS and TPHA were 100% accorded in primary and congenital s., while in late latent s., 95.3%: cases with positive FTA-ABS and negative TPHA were 4.1%, and the contrary, 0.6%.
3) For the purpose of diagnosing the healing or following the course of the disease, cardiolipin reaction is preferred, because the new two methods seemed less calibrating in revealing the changing of antibody titers. The two, however, were shown very useful in differentiating biological false positive reaction (BFP) or diagnosing the sera with unreliable results with cardiolipin reaction.
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