Health adults were administrated with antibiotics in the following way: each antibiotic of Colistin (CL), Aminobenzylpenicillin (AB-PC), Lincomycin (LCM), Cephalexin (CEX), Kanamycin (KM), and Rifampicin (RFP) was given to two persons per os with ordinary dosage for three days, and changes in total amounts of fecal flora, bacterial constituents, and fecal urobilin-bilirubin ratio were studied.
Total amounts of aerobes were not changed except two persons: a marked decrease in case who took RFP and a slight increase in another case who took LCM were experienced. On the other hand total amounts of anaerobes were markedly decreased in most of the cases except both of two cases with CL and KM administration, and one case with RFP administration. It was found that changes of total amounts of aerobes were dependent on the number of E coli or Enterococcus, while anaerobes were mostly represented by Bacteroides. Though most of cases showed no remarkable decrease in aerobes, there were noteworthy alternations in the kinds of microorganisms.
Fecal urobilin-bilirubin ratio was generally paralleled to the total amounts of anaerobes. Consequently, it was considered that anaerobes played an important role in the reduction of bilirubin to urobilin.
抄録全体を表示