Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
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Volume 46, Issue 11
Displaying 1-5 of 5 articles from this issue
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  • Antistreptolysin-O Titers in the Course of Rheumatic Fever Receiving Oral Penicillin Prophylaxis
    Teiichi ODA
    1972 Volume 46 Issue 11 Pages 411-416
    Published: November 20, 1972
    Released on J-STAGE: September 07, 2011
    DOIhttps://doi.org/10.11150/kansenshogakuzasshi1970.46.411
    JOURNAL FREE ACCESS
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    The efficacy of oral penicillin prophylaxis against the recurrence of rheumatic fever is quite remarkable. However, there are some unsolved points as to the actual mechanism of the anti-recurrence effect of penicillin. We can hardly expect that the prophylaxis dose of penicillin does completely kill streptococ i, as well as completely suppress the new infections of streptococci. On the other hand, it is knownthat there are close relations between the acuteness of streptococcal infection and the ocurrence rate or recurrence rate of rheumatic fever.
    This study was intended to clarify whether the penicillin suppresses completely the streptococcal infection or only “slow-downs” the infection in the course of prophylaxis.
    Forty-one rheumatic fever patients followed up during 1 to 7 years were divided into two groups, namely, continuous prophylaxis group (31) and uncontinuous prophylaxis group (10). Mean years of follow up are 3.1 years and 4.7 years, respectively. Frequency of determination of ASO is 2.02 times per patient-year and 2.16 times per patient-year, respectively.
    In the continuous prophylaxis group, there are 8 times of step-ups of ASO over 2 tubes, or 0.0084 times per patient year. In the other group, there are 12 times of the same step-ups, or 0.258 times per patient-year. The frequencies of ASO step-up show statistically significant differences between the two groups (p>0.025).
    In conclusion, the efficacy of oral penicillin prophylaxis of rheumatic fever should be explained by a moderate suppressive effect and “slow-down” effect against the streptococcal infection. It is not likely that these prophylactic procedures destroy the streptococci or entirely prohibit the occurrence of the fection.
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  • Studies on bacteremic diseases
    1. Five cases of staphylococcus epidermidis bacteremia
    H. TAKEDA, F. YAMASAKU, Y. USUDA, Y. KINOSHITA
    1972 Volume 46 Issue 11 Pages 417-425
    Published: November 20, 1972
    Released on J-STAGE: September 07, 2011
    DOIhttps://doi.org/10.11150/kansenshogakuzasshi1970.46.417
    JOURNAL FREE ACCESS
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    We report here five cases of bacteremia due to staphylococcus epidermidis which is generally regarded as a harmless organism.
    The diagnosis of staphylococcus epidermidis bacteremia is very difficult, since the organism may be a contaminant.Therefore, we thought the following criteria of the diagnosis justifiable:
    1) Patients have fever and other symptoms that suggest bacterial infection.
    2) Staphylococcus epidermidis is isolated from arterial and venous blood culture concurrently, or isolated repeatedly from either of arterial or venous blood cultures taken at different times.
    3) The organisms have an uniform pattern of susceptibility to antibiotics.
    4) Patients improve clinically by the treatment of antibiotics sensitive to the organism.
    The clinical courses of our patients resembled more closely to subacute bacterial endocarditis due to streptococcus viridans than staphylococcus aureus bacteremia.
    Although in our patients a usual dose of ampicillin, tetracycline or chloramphenicol had been administrated before hospitalization, clinical recovery was not reached. In the therapy after admission, cephaloridine (1.5-4.0 gm/day) was effective to three cases, a combination with cloxacillin (3.0 gm/day) and rifampicin (0.9 gm/day) to one case, and kanamycin (1.0 gm/day) or vistamycin (2.0 gm/day) to remaining one case. Further, in a few cases, a combined administration with antibiotic and predonisolone or Irgapyrin (Phenylbutazone plus Aminopyrine) was effective.
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  • [title in Japanese]
    [in Japanese]
    1972 Volume 46 Issue 11 Pages 442-444
    Published: November 20, 1972
    Released on J-STAGE: September 07, 2011
    DOIhttps://doi.org/10.11150/kansenshogakuzasshi1970.46.442
    JOURNAL FREE ACCESS
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    [in Japanese]
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  • [title in Japanese]
    1972 Volume 46 Issue 11 Pages 445-446
    Published: November 20, 1972
    Released on J-STAGE: September 07, 2011
    DOIhttps://doi.org/10.11150/kansenshogakuzasshi1970.46.445
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1972 Volume 46 Issue 11 Pages 447-449
    Published: November 20, 1972
    Released on J-STAGE: September 07, 2011
    DOIhttps://doi.org/10.11150/kansenshogakuzasshi1970.46.447
    JOURNAL FREE ACCESS
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