感染症学雑誌
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
48 巻, 12 号
選択された号の論文の6件中1~6を表示しています
  • 西村 忠史
    1974 年 48 巻 12 号 p. 489-491
    発行日: 1974/12/20
    公開日: 2011/09/07
    ジャーナル フリー
  • 稲冨 恵子
    1974 年 48 巻 12 号 p. 492-508
    発行日: 1974/12/20
    公開日: 2011/09/07
    ジャーナル フリー
    It is frequently difficult to determine the pathogenicity of Pseudomonas aeruginosa even when they are isolated from the patients, because of the probable “colonization”. One of the criteria to differentiate the “colonization” from the “infection” is isolation of the organism continuously for prolonged period. Such kind the approach is very time-comsuming and unpractical in the clinical medicine. Therefore, immunological analysis to evaluate chronicity of the infection were carried out in clinical subjects and experimentally infected animals.
    The study was composed of the agar-gel precipitation test (Ouchterlony) between sera of patients and “Cell-sap antigens” and the indirect hemagglutination (OEP-IHA) test between sera from the patients and original endotoxin protein.
    “Cell-sap antigens” were prepared by ultrasonic destruction of Pseudomonas aeruginosa. Original endotoxin protein for OEP-IHA test was supplied from Institute of Medical Science, University of Tokyo. Results of both tests were analysed correlating with clinical signs and findings such as number of colonies of Pseudomonas aeruginosa in the culture plate, duration (of the period) yielding organism in clinical materials, amount of sputum expectorated per day, values of ESR, CRP test and WBC in the blood and administration of steroid hormones.
    Following results were obtained.
    1. In sera of 30 normal human subjects studied as the control group, the precipitating antibodies against the “Cell-sap antigens” were not detected.
    2. In 36 patients in whom Pseudomonas aeruginosa was isolated from clinical materials such as sputum, urine, blood and pus from infected decubitus, the precipitating antibodies were found in sera of 24 patients (64%). The highest positive result (74%, 20 out of 27 patients) was obtained in the patients of respiratory disease in whom the organisms were isolated in the sputum.
    3. In patients in whom the organisms were continuously found in the sputum, the precipitating antibodies were detectable in sera of 18 out of 22 patients, and in patients in whom the organisms appeared in the sputum or urine transitorily, the test was negative, no matter whether they were numerous or few.
    4. The high positive rate of the agar-gel precipitin test was obtained in correlation with the amount of sputum expectorated per day.
    5. Number of WBC in the blood, CRP positiveness and ESR were not directly correlated with the positive rate of the test.
    6. The administration of steroid hormones gave no obvious influence on the results of the test.
    7. The precipitating antibodies were confirmed in the sera of the rabbits infected with the organisms by intratracheal instillation.
    8. The correlative result between the agar-gel precipitin test and OEP-IHA test was simultaneously shown.
    From these results, it is suggested that the agar-gel precipitin test using “Cell-sap antigens” produced from Pseudomonas aeruginosa is applicable to differentiate the patients who were under prolonged (and continuous) infection of the Pseudomonas aeruginosa from those in whom the organisms were found transitorily.
    The test is considered to be useful in clinical analysis of Pseodmuonas aeruginosa infection.
  • 平田 佳子
    1974 年 48 巻 12 号 p. 509-517
    発行日: 1974/12/20
    公開日: 2011/09/07
    ジャーナル フリー
    The inhibitory action of Streptococcus (Str.) sanguis I 10556, Str. sanguis II 10557, Str. salivarius I 9759, Str. salivarius II 13419, Str. mitis 9811 and Str. MG 9895 on the growth of Staphylococcus (Staph.) aureus 209 P and 48 strains of Staph. aureus isolated from the saliva was investigated using the spread and the stab method.
    The growth of Staph. aureus was inhibited by 98% by Str. sanguis I, II and by 62% by Str. mitis but not inhibited by Str. salivarius I, II and Str. MG. On ß hemolytic streptococci (Group G and H), only some of above mentioned species (Str. sanguis II, Str. salivarius I and II) have shown inhibitory activity.
    It was found that 61% of laboratory-stocked 33 strains of viridans streptococci and 71% of newly isolated 45 strains inhibited the growth of before mentioned Staph. aureus. The newly isolated ones showed higher incidence of the inhibitory activity than laboratory-stocked ones. However, it can not be taken as it was, because some strains were observed to lose or increase their inhibitory activity during the stock culture.
    In four persons, streptococci and staphylococci were sought in various sites of the oral cavity. Then, the interactions between them were investigated. On the one hand, viridans streptococci were isolated in high frequency from various sites and staphylococci were found only from salivaor tongue and not from dental plaque at all, on the other. Inhibitory action of streptococci strains from dental plaque and tongue was found stronger than those from saliva.
    The inhibitory activities were found strongest in neutral, media and were passablethrough the dialysis membranes and completely destroyed by heating at 60°C for 30 minutes.
  • 山田 俊彦, 只野 寿太郎, 塩川 優一, 宮本 泰
    1974 年 48 巻 12 号 p. 518-524
    発行日: 1974/12/20
    公開日: 2011/09/07
    ジャーナル フリー
    The importance of group A hemolytic streplococci in the etiology of rheumatic fever and acute nephritis has been well documented. Further, there are many reports on the epidemiological significance of antistreptolysin-O titer and antistreptokinase titer as related to streptococcal infection, rheumatic fever, and acute nephritis. Therefore the studies on rheumatic fever and acute neptritis should be based on epidemiology of streptococcal infection.
    In order to study the change in the type distribution which accurred after the return of Okinawa to Japan in May, 1972, throat culturing for beta hemolytic streptococci was carried out annually among school children in Okinawa since March, 1971. The isolated strains of group A hemolytic streptococci were then examined serologically by T-agglutination method.
    Moreover, the distributions of antistreptolysin-O titer and antistreptokinase ti ter in Okinawa were examined in 1973.
    The conclusions of this research are as follows:
    1) The incidence of beta hemolytic streptococci among school children has been higher in all regions of Okinawa than in any of the other regions of Japan.
    2) T-12 was as dominant in Koza city as in Tokyo.
    3) The predominant types were different among the Miy ako islands.
    4) In Hateruma island, the dominant type has changed from T-11 to T-28, after the return of Okinawa to Japan.
    5) T-14 was isolated from every region of Okinawa as one of the predominant types.
    6) Although the isolation rate of beta hemolytic streptococci has been high in Okinawa, the mode of the antistreptolysin-O titer distribution and also antistreptokinase titer distribution was considerably low.
  • 磯貝 元
    1974 年 48 巻 12 号 p. 525-527
    発行日: 1974/12/20
    公開日: 2011/09/07
    ジャーナル フリー
    米国教育厚生省 (Department of Health. Education, and Welfare) の定期刊行物に, Center for Disease Control (CDC) から“Morbidity and Mortality Weekly Report”(MMWR) という週刊パンフレットが発行されています.内容は合衆国の屈出伝染病の週間州別発生速報が主ですが, ほかに各種疾患の集団発生報告や調査記録なども載つています. その中から興味ありそうな記事を選んで紹介しましよう
  • 1974 年 48 巻 12 号 p. 528-530
    発行日: 1974/12/20
    公開日: 2011/09/07
    ジャーナル フリー
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