感染症学雑誌
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
48 巻, 2 号
選択された号の論文の5件中1~5を表示しています
  • 戸谷 徹造, 天野 富貴子, 石川 直, 三宅 董
    1974 年 48 巻 2 号 p. 41-46
    発行日: 1974/02/20
    公開日: 2011/09/07
    ジャーナル フリー
    It is well known that in the course of antibiotic treatment there sometimes occur alterations in enteral bacterial populations and superinfections as a results of the disruption of the usual enteral bacterial flora. It is also recognized that the certain bacterial flora such as enterococci can provide the host animals with the resistance to some intestinal infections such as salmonellosis.
    The authors tried Entomol-San, an antibiotic resistant enterococcus (streptococcas faecalis BIO-4R) preparation on patients of bacillary dysentery, its suspects, and salmonellosis and its clinical effects were evaluated in this paper.
    Entomol-San was administrated in combination with antibiotics and its eradication effects on Shigella and Salmonellae were compared with the control (cases with antibiotic only). Recognizable differences were not observed between them. However, in the effects to the normalization of the stool appearances Entomol-San yielded better results than antibiotic alone. In the cases with Entomol-San and antibiotics, the mean requiring day for the normalization of stool appearances was 3.3 in 11 dysentery cases, 5.63 in 11 salmonellosis, and 3.47 in 15 cases of acute enteritis without known pathogens. These data appeared obviously superior to the results obtained by the 1971's study team in antibiotic therapy of intestinal infectious diseases.
    Further, the bacteriological investigations revealed that BIO-4R strains could often be recovered from the feces of the patients after Entomol-San administrations. In the mixed culture, the drug resistance of BIO-4R was not transferred into Escherichia coli K-12 strains.
  • 近藤 房生, 土門 春樹
    1974 年 48 巻 2 号 p. 47-56
    発行日: 1974/02/20
    公開日: 2011/09/07
    ジャーナル フリー
    Biological characteristics, identification, pathogenicity against mice and sensitivity to various chemotherapeutic drugs were studied on 23 strains of Mycoplasma isolated from rats and mice suffering from the so-called chronic respiratory disease (CRD). The results obtained were as follows:
    1) The isolates could grow well in the basal PPLO medium supplemented with 20 ml of pooled horse serum and 10ml of a 25% extract of fresh yeast per deciliter at 37°C under aerobic condition.
    After ten-day incubation, size of large colonies grown on the agar medium was 1 mm in diameter.
    The organisms fermented dextrose, maltose and dextrin, but they were inactive against galactose and lactose. When 48-hour cultures were tested, the reduction of methylene blue rapidly completed. However, they did not reduce 2, 3, 5-triphenyl-tetrazolium chloride (TTC) under aerobic conditions. Production of film and spot was shown only in one out of 23 strains.
    2) These isolates were identified to be Mycoplasma pulmonis based on their biological characteristics and the results obtained in growth inhibition and double gel diffusion tests.
    3) Using the antisera that were absorbed with the liquid medium to remove the antibodies against the ingredients of this medium, especially horse serum, double gel diffusion test showed that M. pulmonis has two to three common antigens.
    4) Complement fixation antibody titers in sera from mice at the 30 days after intravenous inoculation were measured at a high level of 1280 to 5120.
    5) Intravenous inoculation with about 109 CFU/ml of isolates' strain suspension in physiological saline solution caused polyarthritis in mice 3 to 20 days later. Frequency of pneumonia induction was lower than that of appearance of polyarthritis. Mycoplasma was recovered from these affected tissues of the inoculated animals.
    6) Intramuscular administration of hydrocortisone acetate (2.5mg/mouse) induced in higher rate pneumonia, but much the same about polyarthritis compared with cortisone non administrated group.
    7) The pathogenicity against mice of the strain was maintaned even after 50 subcultures in culture medium.
    8) Those isolates were equally sensitive to various chemoterapeutics such as macrolide antibiotics, nitrofurantoins and chloramphenicol, lincomycin, mikamycin, streptomycin and kanamycin.
  • 藤田 晃三, 古山 正之, 児玉 進, 村山 隆志, 滝本 昌俊, 吉岡 一
    1974 年 48 巻 2 号 p. 57-62
    発行日: 1974/02/20
    公開日: 2011/09/07
    ジャーナル フリー
    One handred and fourty strains of Pseudomonas aeruginosa (Ps. aerug.) isolated from clinical materials in the Hokkaido University Hospital during 1970 to 1971 were typed serologically by means of Homma's agglutination method utilizing a routine set of 13 standard sera, and susceptibilities of them to several kinds of antibiotics were determined. The results obtained were compared with those of our previous report in 1970.
    One handred and twenty-five strains (89.3%) were typable with an occurence of type T5 in 43 strains (30.7%), type T8 in 38 (27.1%), type T7 in 12 (8.6%), type T10 in 11 (7.9%) and small numbers of strains were distributed in the other types. Three strains showed agglutination with two standard sera simultaneously and twelve strains (8.6%) were nontypable.
    The strains of Ps. aerug. were resistant to common antibiotics such as streptomycin and kanamycin, with minimum inhibitory concentrations (MIC) of more than 25mcg/ml, the level obtainable in the sera by usual dosage of these drugs.
    A peak of MIC distribution in carbenicillin and sulbenicillin was at 100mcg/ml and cross resistance was observed between these two antibiotics. Twelve per cent of strains were found to be highly resistant to both antibiotics with MIC of 400mcg/ml or more, a finding which was not observed in our previous study in 1970. Emergence of highly resistant strains to gentamicin, colistin and polymixin B was not observed.
    The type T5 strains were found to be more resistant to the above mentioned six antibiotics tested than the type T8 strains except for sulbenicillin.
  • 磯貝 元
    1974 年 48 巻 2 号 p. 63-65
    発行日: 1974/02/20
    公開日: 2011/09/07
    ジャーナル フリー
    米国教育厚生省 (Department of Health, Education, and Welfare) の定期刊行物に, Center for Disease Control (CDC) から“Morbidity and Mortality Weekly Report”(MMWR) という週間パンフレットが発行されています。内容は合衆国の届出伝染病の週間州別発生速報が主ですが, ほかに各種疾の患集団発生報告や調査記録なども載つています. その中から興味ありそうな記事を選んで紹介しましよう.
  • 1974 年 48 巻 2 号 p. 66-71
    発行日: 1974/02/20
    公開日: 2011/09/07
    ジャーナル フリー
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