The total of 204 pregnant women admitted for delivery in a hospital in Tokyo during the period of October 1971-January 1972 were investigated on their history of acute infectious diseases and family history by questionnaire and their circulating antibodies including cord blood. The results obtained are summarized as follows: 1) The average age of the mothers was 27.1 years and the average number of brothers and sisters was 3.8 and the first and second births occupied 88.2% of the total births. 2) Diphtheria antitoxin, Rubella HI antibody, and Toxoplasma antibody in the circulating blood of the mothers were examined; 72.6% had the value less than 1/30 IU of diphtheria antitoxin, 92.3%, positive Rubella HI, and 32.5% more than 1: 32 toxoplasma antibody. 3) The total of 74 (36.3%) among 204 mothers had T-agglutinin against group A streptococci including T1, T3, T4, T6, T8, T9, T12, T25, T44, B3264, and T-agglutinin against T4 and T6 were most prevalent. And, among 120 pair sera of mothers and placental cord bloods, the total of 33 (27.5%) mothers were positive in T-antibody and the total of 27 (81.7%) cord bloods among them were also positive in T-ag-glutinin of the same type to the mother, clearly demonstrating placental transfer of T-antibody.
A 29 year-old housewife was diagnosed as having Hodgkin disease by a needle biopsy and hospitalized. During the course of the therapy with vincristine, endoxan, 6-mercaptopurine, prednisolone, 60Co and so on, cryptococcal meningitis and bacterial meningitis developed. Cryptococcal meningitis relapsed several times in spite of amphotericine-B and 5-fluorocytocine therapy. Bacterial meningitis was found to be due to Clostridium sordellii.
Salmonella paratyphi A strains were isolated from the blood or feces of three patients who visited Bandung, Java, Indonesia from July to September 1974. These three cases progressed with mild clinical signs. The phagetype of isolated strains was determined as Type 4. These strains showed unusual fermentation to two carbohydrates on Barsiekow medium. These strains fermented mannitol after 7 days-cultivation but not in the case of sorbitol within a month. On the other hand, these strains showed usual fermentation as Salmonella paratyphi A on the modified Barsiekow medium containing meat extracts within 24 hours. The results were confirmed by a repeated examination. These strains imported from Indonesia by travellers are evidently different from typical strain, and it is thought that the characteristics of these strains can be used as epidemiological markers.