A 56-year-old male patient was admitted to National Hospital, Kyushu Cancer Center, on April 1974, under the diagnosis of acute myeloic leukaemia, and was treated with antileukaemics, adrenocortical hormon, and blood-transfusions. During the period from June 6, to July 8, non-fermentative Gram-negative rods of identical character were isolated from 10 oropharyngeal swabs, 1 sputum and 2 pus samples of decayed tooth. One of these isolates (KM 1707) was studied in detail. It was a non-motile, indophenol oxidase-positive rod, produced indole in SIM medium, and oxidized glucose and lactose. KM 1707 was thus identified as a strain of Flavobacterium meningosepticum The serotype of the strain was determined as A by slide agglutination test with a set of monovalent antisera against F. meningosepticum serotypes A through F prepared by Terada and Sugiyama, Toshiba Research Institute for Biological Science, Niigata. Although the patient got a complete remission of leukaemia and F. meningosepticum which colonized in his oropharyngeal region disappeared without causing any serious infection, he died on December 1, 1974, from severe bilateral bronchopneumonia and fibrinous pleurisy due to Pseudomonas aeruginosa and Enterobacter species. F. meningosepticum was not detected from the autopsy lung specimens.
Eleven cases of neonatal meningitis caused by F. meningosepticum strain of either serotype C or E, and an adult case of subacute bacterial endocarditis due to a serotype F strain have so far been reported in Japan. Present report also described additionally an episode of F. meningosepticum isolation from pus of nucha furuncle in an adult male patient. Incidence of cases of F. meningosepticum infection in various countries were reviewed. The distribution of the organism in our environment and the mode of entry of the organism into tissues should be clarified in order to prevent serious infection in premature or debilitated individuals.

View full abstract

In successively voided samples the concentration of bacteria which are logarithmically growing in the urinary bladder shows a progressive fall, if the bladder is emptied in appropriate circumstances. By making a number of assumptions about conditions of bacterial growth in the bladder and of evacuation of the bacteria, the way in which this washout of the bacteria will occur may be theoretically predicted. A following mathematical model is proposed here to give such prediction:
_??_
N. is the number of bacteria in the bladder at zero time; Nk is the number of the bacteria in the bladder just before the kth voiding counting from zero time; g is the generation time of the bacteria measured in minutes; Tk is the time measured in minutes between the (k-1) th and the kth voiding; Rk is the rate of residual urine left in the bladder just after the kth voiding represented by percentage; R is the hypothetical constant rate of residual urine represented in percentage and R. is the critical rate of reidual urine represented by percentage.
Two new concepts of “critical rate of residual urine” and “normal rate of residual urine” are presented to resolve the equation. The latter means the ratio of urine on the surface of the normal bladder just after complete washout to the volume of voided urine. The former means a rate at which the bacteria remains constant in number; and suggests that the bacteria keeps on increasing in number at every micturition if the patient has residual urine above the rate. It also suggests the reverse in the patient who has residual urine below the rate. “Critical rate of residual urine” is calculated by an equation:
_??_
Graphs are related to how many times the patient must void in a given period to clear the bladder of the bacteria.

View full abstract