Attempts were made to isolate virus from throat swabs obtained from outpatients suffering from acute undifferenciated febrile illnesses who visited a pediatric clinic in Fujinomiya City, Shizuoka Prefecture.
Specimens were collected over 6 year period, from March 1968 to March 1974, for virological and epidemiological examinations ; and the following conclusions were drawn.
1. Eight hundred and eighty two strains of various viruses were isolated from 4, 972 specimens. The species and type of isolated virus were consisted of influenza A (H3N2) and B; parainfluenza virus type 1, 2 and 3; adenovirus type 1, 2, 3, 5 and 6; enterovirus type, Cox.A7, 9 and 16; Cox.B1, 2, 3, 4, 5 and 6; Echo type 9, 11 and 17; poliovirus type 1 and 2; and herpes simplex virus.
2. Virological and serological investigations on patients of respiratory disease in summer of revealed that influenza B virus continued to be prevailing during summer 1973, suggesting the continuance of transmission of influenza virus in the period when influenza virus is not usually prevalent.
3. Parainfluenza virus was found to have a seasonal predilections, depending on its type. It is of interest that such closely related viruses have different seasonal variations of prevalence.
4. Each clinical type of disease occurred during various seasons. The common cold, bronchitis, catarrhal croup, exanthema subitum, tonsillitis, asthmatic bronchitis, and pneumonia were observed throughout the year. Tentative diagnosis of acute febrile illness, tentative diagnosis of acute exanthematous disease, pharyngo-conjunctival fever, hand foot and mouth disease, herpangina, and aseptic meningitis occurred mainly in the summer. Influenza were mainly seen in the winter.
5. There was no doss relationship between clinical types of disease and viruses isolated. Both virus recovery and the clinical type of disease were related to the seasonal fluctuations.
6. A cyclic infection and the interference phenomenon induced by enterovirus were discussed virologically and epidemiologically.
7. Epidemiological studies were perfromed on Cox.B6 isolated from patients with disease of the respiratory tract, and on poliovirus derived from the live vaccine.

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A multi-clinic double blind study was conducted to examine the therapeutic effects and safety of fenbufen (FB), 3-(4-biphenylylcarbonyl) propionic acid, a new non-steroidal anti-inflammatory agent, comparison with ibuprofenPatients with common cold were divided into two groups, one with FB 900 mg/day, and the other, with IP 900 mg/day, each group being treated for 4 days. Treated and statistically analyzed cases were 115 with FB and 114 with IP, 229 in total. (IP), on the common cold.
As the result of overall evaluations done at 2nd and 4th treatment days, no significant differences were observed between the two groups. Twenty-two clinical symptoms and signs were assessed individually, with a rating scale, of the complete relief, improvement, exacerbation, or manifestation; however, no significant defferences were found between the two drug groups.
Side effects were reported 3 cases in FB group and 4 cases in IP group, and most of them were gastrointestinal disturbances. Here, too, no significant differences were shown between the two groups.
As stated above, in the therapeutic efficacy and safety, FB and IP demonstrated similar clinical results, and consider FB to be a highly useful drug for the common cold.

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