感染症学雑誌
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
52 巻, 2 号
選択された号の論文の3件中1~3を表示しています
  • 大友 弘士, 山口 剛, 石崎 達, 加納 六郎
    1978 年 52 巻 2 号 p. 41-49
    発行日: 1978/02/20
    公開日: 2011/09/07
    ジャーナル フリー
    The status of infection was studied on 29 patients with malaria. The 29 patients included 28 patients with imported malaria, consisting of 22 with Plasmodium vivax, five with P. falciparum, and 1 with vivaxfalciparum mixed infection. Besides these 28 patients, there was one vivax malaria patient with domestic infection.
    The cases with falciparum malaria all developed as early as within 21 days after the repartriation of the patients to Japan from the areas where it was prevailing. On the other hand, only about half of the cases with vivax malaria evolved within one month after the return of the patients to Japan, and the other half developed not less than 2 months after the repatriation of the patients: thus, there was an apparent difference between these cases and the cases of falciparum malaria.
    Seventeen with 28 patients with imported malaria had not received chemoprophylaxis in the respective malaria-prevailing areas. Out of the people who had received the chemoprophylaxis, on the other hand, there were 9 patients with P. vivax (40.9%) and two with P. falciparum (40.0%); however, chemoprophylaxis in all of these patients had been insufficient both in dosage and medication period.
    Both the patients with P. vivax and those with P. falciparum were, in principle, treated with chloroquine to control the pyretic attack. Then, the patients with P. vivax and the one with mixed infection were medicated with primaquine 15 mg base/day, for 14 days as radical treatment to prevent relapse. Despite this treatment, the vivax malaria relapsed in 55 and 88 days in two of the patients with this infection, and both of the two had been infected in New Guinea. Attention should be called to the report that there is a primaquine-resistant P. vivax (Chesson strain) infection, the relapse of which cannot be completely prevented with the usual doses of this drug, in the vivax malaria prevailing in New Guinea. Therefore, a particular care is necessary in prescribing the dosage of primaquine for the treatment of the patients infected by P. vivax in New Guinea.
  • 橘 宣祥, 楠根 英司, 津田 和矩, 玉利 一博, 福島 勇, 皆越 真一, 児玉 健二, 草場 公宏, 松本 勲, 小林 譲
    1978 年 52 巻 2 号 p. 50-55
    発行日: 1978/02/20
    公開日: 2011/09/07
    ジャーナル フリー
    Complement-fixing antibody in sera of animals experimentally infected with R. sennetsu and of patients with sennetsu rickettsiosis found in Miyazaki district were detected by using soluble (S) and particulate (P) antigens, and following results were obtained.
    1. Although R. sennetsu infected mice could not survive even after treatment with tetracycline, antibody titers were recognized 7 days after infection, reached the maximum in 3-4 weeks, and remained at high level after that. Titers against P antigen were somewhat higher than those against S antigen, but both patterns of rise and fall of the titers were almost same. In guinea pigs, antibodies were found 14 days after infection. The maximum titer was observed after 3-4 weeks. The titer declined gradually after that. In hamsters, titers against P antigen rose after 17 days and high titers lasted after that. However, those against the S antigen were temporarily recognized from 17 to 21 days after infection.
    2. Sera from four patients had relatively high titers against P antigen. In three of 4 cases, antibody titers were demonstrated on the 12th day of illness when R. sennetsu was isolated from their venous blood. In three cases, antibody against S antigen was detected. In general, titers against P antigen were higher than those against S antigen.
  • 1978 年 52 巻 2 号 p. 63-65
    発行日: 1978/02/20
    公開日: 2011/09/07
    ジャーナル フリー
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