The importance of group A hemolytic streptococci in the etiology of rheumatic fever and acute nephritis has been well documented. Further, there are many reports on the epidemiological significance of antistreptolysin-O (ASO) titer and antistreptokinase (ASK) titer as related to streptococcal infection, rheumatic fever and acute nephritis. Therefore, the studies on rheumatic fever and acute nephritis should be based on epidemiology of streptococcal infection. We studied on relations between the change in the T-type of beta hemolytic streptococci and antibodies distribution among healthy school children living in Toda City, Saitama prefecture since July 1974 to February 1976. The conclusions of this research are as follows: 1. The incidence of beta hemolytic streptococci among school children was low in summer season and high in winter season. 2. The incidence of abnormal high ASO titer or ASK titer was high in Toda City than in the rural area (Okinawa), respectively. When T-type 3 was most dominant in February 1975, rate of abnormal ASO, ASK titer were highest. 3. The isolation rate of T-type of 4, 6, 12 were low but T-type 3 was most dominant and T-type 1 was slightly increasing in this survey.
Recent causal organisms of bacteremia were investigated for five years in Itabashi Nihon Univ. Hospital. The result indicated that bacteria with low-virulence and antibiotics-resistance are increased for causal organisms of bacteremia. And a case of acute leukemia, complicated with Trichosporon cutaneum septicemia, was reported.
Edwardsiella tarda is included the family Enterobacteriacae recentry recognized as probably normal intestinal inhabitant of such animals as snakes, seals and alligators. Although occationally found from human, the role of Edwardsiella tarda in producing disease in man has not known. We isolated a strain of Edwardsiella tarda from duodenal juice and feces of a hospitalized man with chronic cholangitis. He was a 48 years old male who had had cholecystectomy because of the complication with prulent cholecystitis following appendectomy at 31 years old. And then he has repeated the symptoms of chronic cholangitis such as high degree of fever with chills and right hypochondralgia. So he was admitted to Ehime Univercity Hospital because of further precise examination. Admitting to the hospital, he was asymptomatic. We, however, isolated Edwardsiella tarda with E. coli, Klebsiella and Pseudomonas aeruginosa from the duodenal juice. And we also isolated these microorganisms from the feces. Thus, because of mixed infection we could not clarisfy the disease due to Edwardsiella tarda only. But we considered that it might play a part of the role of chronic inflammation. Antimicrs bial sensitivity tests using Disc method showed that our newly isolated Edwardsiella tarda was sensitive to aminobenzylpenicillin, sulbenicillin, carbenicillin, cephaloridin, cefazolin, kanamycin, streptomycin, gentamicin, tetracycline, chloramphenicol and pyromidic acid.