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Volume 53, Issue 2
Displaying 1-10 of 10 articles from this issue
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[in Japanese], [in Japanese], [in Japanese]1979 Volume 53 Issue 2 Pages 45-47
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSDownload PDF (342K) -
Keimei MASHIMO1979 Volume 53 Issue 2 Pages 48-51
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSCefmetazole is useful for the infections above middlegrade due to Gram-positive and -negative bacteria. Effectiveness of the drug is expected especially against f-lactamase-producing bacteria. Futhermore the drug is effective against Indole-positive Proteus and Serratia to which the effective antibiotics were hitherto scanty, and thus cefmetazole may be highly evaluated.View full abstractDownload PDF (329K) -
Sachiko GOTO1979 Volume 53 Issue 2 Pages 52-65
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSCefmetazole is a new substance of broad spectrum, effective against both Gram-positive and -negative bacteria. Its antibacterial action was resistant to bacteria producing P-lactamase, similarly to analogous cefoxitin, and an effectiveness was observed against cephalosporin resistant bacteria.
Cefmetazole demonstrated an antibacterial action against Indole-positive Proteus and Serratia, to which the existing cephalosporins have shown only a weak sensitivity, and this effectiveness was confirmed by in vivo experiment.View full abstractDownload PDF (1267K) -
Yukimichi KAWADA1979 Volume 53 Issue 2 Pages 66-74
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe results of studies in 32 research institutes in Japan regarding absorption, excretion, distribution and metabolism of cefmetazole are summarized as follows:
After intramuscular injection, one-shot intravenous injection or intravenous drip infusion, cefmetazole is rapidly absorbed and transferred into blood resulting in high blood concentrations and its disappearance from blood is faster than CEZ but slower than CET, somewhere in between these two drugs in the blood concentration half life.
Excretion of cefmetazole into urine is favorable, indicating that it is not metabolized in vivo and the major portion is excreted in urine in unchanged active form.View full abstractDownload PDF (876K) -
Kohei HARA1979 Volume 53 Issue 2 Pages 75-81
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSCefmetazole has a wide spectrum of antibacterial activity not only against gram-positive bacteria but also against gram-negative bacteria including E. coli, Serratia, Klebsiella, Proteus and Citrobacter, against which other antibiotics of Cephalosporine group are ineffective. The antibacterial activity of cefmetazole has been proven in the clinical cases in the field of internal medicine: following the administration of cefmetazole, eradication of gram-negative bacilli at the rate of 60 to 85% was observed in our study.
Consepuently, excellent clinical responses were noted in chronic infections of urinary and respiratory tracts caused by gramnegative bacilli. We have obtained the high efficacy rate of 82.9%(296 effective cases out of total 357 cases) with cefmetazole which should be rated as one of the most effective among known Cephalosporine antibiotics, as the overall efficacy rate of the antibiotics of this group applied to the patients in the field of internal medicine was between 64.9 and 84.0% which was obtained in the nation-wide survey.View full abstractDownload PDF (817K) -
Kiyohito SHIBATA1979 Volume 53 Issue 2 Pages 82-86
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSAs the excretion of cefmetazole into bile is rather favorable among cephalosporin derivatives, and its bile concentration is nearly comparable to that of CEZ, its effectiveness against biliary tract infections was expected to be favorable due to the fact that the most common pathogenic microorganisms we found in biliary tract infections including E. coli, Klebsiella, Proteus and occasionally Serratia and anaerobic Bacteroides are fairly susceptable to cefmetazole.
The result of survey satisfactorily reflects the above, and the efficacy rate in the field of surgery was 90%(effective in 9 out of 11 cases) and the overall efficacy rate through Phase la of the survey in the field of surgery and internal medicine was 77.8%(excellent and good response in 28 out of 36 cases).
No appreciable side effect was observed in the field of surgery.
From the above, we evaluate that as a cephamycin derivative, cefmetazole is an excellent antibiotic agent against E. coli and Klebsiella in the field of surgery.View full abstractDownload PDF (476K) -
Joji ISHIGAMI1979 Volume 53 Issue 2 Pages 87-97
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSThe clinical evaluations of cefmetazole in various urinogenital infections, which were obtained at 13 clinical institutes in Japan, were summarized in this report.
Of the total 211 cases given cefmetazole analyses were made of 204 cases: complicated infections were predominant (184 cases) among acute and chronic cases, and efficacy rate of 66.3% was obtained with cefmetazole. Bacteriologically, cefmetazole showed the effective rates of 74.5% and 90.2% against Serratia and Proteus, respectively.View full abstractDownload PDF (939K) -
Zenjiro TAKASE1979 Volume 53 Issue 2 Pages 98-105
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSClinical evaluations of cefmetazole in 75 cases (ages 20 to 70) of infectious diseases in the field of obstetrics and gynecology, including genital infections (such as intrauterine, intrapelvic and external genital infections), simple urinary tract infections and post-operative (genital carcinoma) complicated urinary tract infections, were collected and analyzed.
The routes of administration were: 48 cases of drip infusion, 22 cases of intravenous injection, 3 cases of intramuscular injection and a case each of combinations of drip infusion with intravenous injection or topical injection.
The daily doses were: 31 cases of 1.0 g, 27 cases of k2.0 g, 2 cases of 3.0 g, 7 cases of 4.0 g, 2 cases of 0.5 g and a case of 1.5 g, with 46 cases using the daily doses for 4 to 5 days, and the longesi period of administration was 14 days.
The effective rates by types of diseases were: 94.1% in genital infections, 92.5% in the cases of urinary tract infections, and the overall rate of efficacy in the field of obstetrics and gynecology was 93.3%.
The effective rates by isolated microorganisms were: 100% against gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus), 93.0% against gram-negative bacteria (E. coli, Klebsiella, Enterobacter, Proteus, GNR), 87.5% against a mixture of two types of bacteria, 66.7% against a mixture of 3 types of bacteria, and the overall effective rate was 91.7%.View full abstractDownload PDF (711K) -
Kazufuto FUKAYA1979 Volume 53 Issue 2 Pages 106-108
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSOf 708 patients treated with cefmetazole clinical symptoms considered to be attributable to side effects of this agent were observed in 13 cases or 18 events. In detail, eruption was experienced in 6, gastrointestinal disorders in 5, headache in 2 and shock-like symptom was in one case respectively.
Muscular pain at the injection site was well tolerated in general.
Abnormalities detected in a variety of labolatory findings and considered to be attributable to cefmetazole administration were relatively small in number and slight in grade.
In historical comparison with previous results about side effects of some cephalosporin derivatives, the rate of appearance proved to be rather low in cefmetazole.View full abstractDownload PDF (241K) -
1979 Volume 53 Issue 2 Pages 109-111
Published: February 20, 1979
Released on J-STAGE: September 07, 2011
JOURNAL FREE ACCESSDownload PDF (410K)
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