Twelve children with acute lymphatic leukemia were performed blood cultures and the measurements of serum immunoglobulins at the onset, the introductory remission stage and the terminal stage, on their clinical course.
Neither positive blood culture nor the decrease of serum globulin were found at the onset or the introductory remission stage even when granulocytopenia and pyrexia were observed.
However, in all 5 cases at the terminal stage positive blood cultures were found.
In 9 cases of positive blood cultures pyrexia and granulocytopenia were observed in 9 and 5 respectively.
The blood cultures showed Staphylococcus aureus, Staphylococcus epidermidis, Bacteroides clostridiiformis, Pseudomonas aeruginosa and Gram positive anaerobic rots.
High rate of morbidity in the bacterial infection was shown in children having less than 500 mg/dl serum globulin, and in these cases the decrease of IgM was remarkable.
Blood cultures were positive in 15.7% of 44 specimens at the terminal stage in spite of antibiotic treatment which often have been cousidered to triggered mixed infections.
Fecal bacterial counts were performed at the time of hospitalization and the terminal stage.
The number of Bifidobacterium decreased from 10
8/g to 10/g and that of Enterobacter increased from 10
6/g to 10
8/g.The fecal pH was 5.4 at time of admission to hospital and 8.3 at the terminal stage.
It is necessary to investigate whether the alteration of the fecal flora and pH depend on the longterm medication of antibiotics or the immunological deficiency of the host.
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