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54 巻, 11 号
選択された号の論文の6件中1～6を表示しています
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庄田 昌隆1980 年 54 巻 11 号 p. 623-626
発行日: 1980/11/20
公開日: 2011/09/07
ジャーナル フリーIn order to determine whether endotoxin is normally found in the portal system, intraoperative samples of portal and peripheral blood were drawn from consecutive abdominal surgery patients. The underlying diseases were as follows, gastric cancer (15 cases), gastric ulcer and duodenal ulcer (6 cases), cholelithiasis (16 cases), choledochus cancer (2 cases), ileus, colon cancer and others. A total number of the patients studied was 48 cases. The limulus lysate test was employed to detect endotoxin. Eleven patients (23%) had a positive limulus test in portal blood. All patients were tested for portal bacteremia and only two showed positive growth. The one was Klebsiella pneumoniae which was isolated from a patient with portal systemic endotoxemia and the another was Streptococcus hemolyticus which was isolated from a patient without portal and systemic endotoxemia. Three of five patients with portal and systemic endotoxemia. Three of five patients with portal and systemic endotoxemia showed slightly abnormal liver function and renal function. In contrast, six patients with portal endotoxemia and without systemic endotoxemia showed normal renal function. This study demonstrated that the kupfer cells of the liver normally protect the systemic circulation from endotoxin and that endotoxin was present in systemic blood only when liver function is imp aired, as some investigators has described.抄録全体を表示PDF形式でダウンロード (558K) -
三木 文雄, 久保 研二, 塩田 憲三, 長浜 文雄, 安田 真也, 中林 武仁, 石丸 修, 阿部 政次, 平賀 洋明, 原田 一紀, 加 ...1980 年 54 巻 11 号 p. 627-693
発行日: 1980/11/20
公開日: 2011/09/07
ジャーナル フリーThe efficacy and safety of cefotaxime (CTX, HR 756) and cefazolin (CEZ) were objectively evaluated in a well-controlled study of respiratory tract infections at 38 institutions in Japan. Patients with pneumonia or chronic respiratory tract infections were given intravenous drip infusions of either CTX or CEZ, randomly assigned, at 4 g per day in two divided doses for, in principle, 14 days. The therapeutic efficacy, adverse reactions, and usefulness of the drugs were evaluated by intergroup comparison.The following results were obtained:
1.There was no statistically significant intergroup difference in therapeutic efficacy.
2.Among patients in which the causative organisms were able to be determined, the bacteriological efficacy of CTX, in terms of eradication rate, was significantly superiorto that of CEZ.
3.There was no significant intergroup difference in the incidence of side effects
4.There was no significant intergroup difference in usefulness.抄録全体を表示PDF形式でダウンロード (6376K) -
竹田 晃男, 和田 英太郎1980 年 54 巻 11 号 p. 694-698
発行日: 1980/11/20
公開日: 2011/09/07
ジャーナル フリーWe have isolated a strain of Salmonella paratyphi C from duodenal juice from the carrier with gallstone. The following result were obtained.
A man, 66 years old, lived in Rabaul from 1943 to 1946 in the world war II, and had had a malaria fever there in 1943.
He returned to Japan. We had a gallstone in his body, and no any other signs except abdominal pain on his clinical examination.
From the clinical examination, he was diagnosed as Gastriculcer, first but on the study of extracted bile from the gallbladder, Salmonella paratyphi C was isolatel from his bile.
The organism was sensitive to NA, AB-PC, CP, KM, TC and CL, but resistant to OM, EM and LM.抄録全体を表示PDF形式でダウンロード (585K) -
加藤 直樹, 徳山 宏基, 蟹本 雄右, 酒井 俊助, 嶋津 良一, 清水 保夫, 河田 幸道, 西浦 常雄, 小林 とよ子, 渡辺 邦友, ...1980 年 54 巻 11 号 p. 699-707
発行日: 1980/11/20
公開日: 2011/09/07
ジャーナル フリーTwo cases of antibiotic-associated colitis due to a toxin produced by Clostridium difficile we rereported.
Case 1: A 55-year-old man underwent left ureterolithotomy and indwelt a catheter in left ureter under diagnosis of left ureteral stone and suspicion of tuberculous ureteral stricture. Although chemotherapy with several kinds of antibiotics was performed against fever after operation, he did not become afebrile completely. On the 37th day after operation perforation of transverse colon was detected by laparotomy. After laparotomy cefazolin was administrated for fever and faint dia rrheawas developed. On the 17th day after laparotomy stool examination was performed and C. difficile (107 cfu/g) and its toxin with high titer were detected.
Case 2: A 68-year-old man underwent partinal cystectomy for bladder carcinoma. Fever was developed after operation and two times of oral administration of amoxicillin on the 3rd day after operation caused an elevation of temperature and diarrhea. Stool culture on the 5th day after operation revealed C. difficile (106 cfu/g) with Klebsiella pneumoniae (105 cfu/g) and a toxin of C. difficile with high titer was also detected.
High grade toxigenicity of two strains of C. difficile isolated from these two patients was substantiated with cytotoxicity in Hela cells, lethal toxicity in mouse and vascular permiability factor in rabbit.
Metronidazol and rifampicin showed high activities against two strains isolated, both of which were generally resistant to the antibiotics used for the treatment before C. difficile isolation.
Antibiotic-associated colitis due to a toxin of C. difficile as reported herein would become one of the problems in use of broad spectrum antibiotics, especially active against anaerobes.抄録全体を表示PDF形式でダウンロード (1124K) -
腸チフス中央調査委員会1980 年 54 巻 11 号 p. 708-719
発行日: 1980/11/20
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (1647K) -
1980 年 54 巻 11 号 p. 752-754
発行日: 1980/11/20
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (355K)
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