A 33-year-old female was admitted to a hospital with chief complaints of abdominal pain, fever, cough and migrating subcutaneous induration. She had consumed half-cooked crabs 3 months ago. On admission, a mass in the abdominal wall, pleural effusion, a nodular shadow in the right upper lung on the chest X-ray and multiple low density areas in the liver on CT. Peripheral blood examination disclosed marked eosinophilia (5, 300/mm3). Although we failed to detect any parasite eggs in stool, sputum and bronchogenic secretion, the immuno-serological test for parasites revealed an infection of paragonimus. Oral administration of praziquantel resulted in the disappearance of nodular shadow in the right upper lung, multiple low density areas on CT as well as migrating subcutaneous indurations. Migration of Paragonimus westermanii larvae to liver is known to be uncommon. Thus, the present case indicates an alternate migration route of the Paraonimus westermanii in humans.
We report a 68-year-old woman with severe falciparum malaria contracted in Tanzania. She presented high parasitemia and was treated successfully with intravenous artesunate, a qinghaosu derivative, and aggressive supportive therapy. She developed hemolytic anemia and jaundice on day 11 and blood transfusion was required. This case illustrates that intravenous artesunate has excellent antimalarial activity with rapid efficacy and that no severe adverse effect but conventional aggressive supportive therapy is still important in the treatment of severe falciparum malaria.