Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 18, Issue 12
Displaying 1-12 of 12 articles from this issue
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  • Charactaristics of splanchnic portal circulation in portal hypertension as analysed by pressure study in clinical cases.
    Kiyoshi INOKUCHI, Michio KOBAYASHI, Motonori SAKU, Naofumi NAGASUE, At ...
    1977 Volume 18 Issue 12 Pages 891-898
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.891
    JOURNAL FREE ACCESS
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    Intraoperative pressure study was made in patients with portal hypertension in order to examine discreteness of splanchnic portal area from portal trunk. Twenty-seven patients with portal hypertension including 21 cirrhosis of the liver and 6 idiopathic portal hypertension and 10 controls were subjected. In each case left gastric vein was ligated as near the junction of portal vein as possible, and catheters were introduced into proximal left gastric vein as well as portal vein for simultaneous pressure measurement. Relationship between occluded left gastric vein pressure (OLGP) and portal vein pressure was simultaneously recorded under with and without portal clamping.
    In control group, OLGP, which was almost the same value to the free portal vein pressure, was found to have followed to the increasing portal pressure, when the portal vein was clamped. In portal hypertension group under portal vein clamping, however, OLGP elevated a little, but did not attain to the height of portal clamp pressure. The difference between the two groups was statistically significant. Quantitative analysis using simulation model for portal circulation suggested that flow resistance between the left gastric artery to the vein in portal hypertension group markedly decreased down to about one-twentieth of the control group, leading remarkable increase of arterial inflow into the portal area.
    Although the study is remained awaited why the increase of arterial inflow takes place in portal hypertension patients, incontinence of the arterio-venous shunt is possible. This postulation is considered to play major role in formation of esophageal varices.
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  • Some factors influenced on the serum transaminase level in a population. Part I
    Sex and age factors related to GOT and GPT in healthy subjects
    Kenichi IDO, Ken KIMURA, Kusuki NISHIOKA, Kiyonobu MIKANAGI, Toshimasa ...
    1977 Volume 18 Issue 12 Pages 899-904
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.899
    JOURNAL FREE ACCESS
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    Population study about serum transaminase (GOT, GPT) was carried out on the 2000 subjects who were living in Toshi Island, Mie Pref. Japan. From the data, sex and age factors related to serum transaminase (GOT, GPT) were studied. The results were following.
    1) The mean value of GOT, GPT was higher in male than in females in almost age group.
    2) In both sex, GOT and GPT had significant correlation with age.
    3) Especially the mean value of GOT, GPT was higher in male than in female among the age of 25th to 50th.
    4) Both GOT, GPT showed lognormal distribution in eath sex and age group. Specially, the pattern was more dominant among younger than aged group.
    These results suggested that sex and age factors strongly influenced to the serum transaminase level in healthy subjects.
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  • Some factors influenced on the serum transaminase level in a population. Part II
    Statistical analysis on some factors related to serum transaminase level
    Kenichi IDO, Ken KIMURA, Kusuki NISHIOKA, Kiyonobu MIKANAGI, Toshimasa ...
    1977 Volume 18 Issue 12 Pages 905-912
    Published: December 25, 1977
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.18.905
    JOURNAL FREE ACCESS
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    Some factors related to serum transaminase level in the Toshi-Island population study were discussed. Statistical analysis was done by computer on eight to eleven items, such as drinking, HBs-antigen, past history of hepatic disease.
    The results were following.
    1) GOT had significant correlation with the history of alcohol intake, HBs-antigen and history of hepatic disease (p≤0.01).
    2) GPT had significant correlation with HBs-antigen (p≤0.01).
    3) Multiple regression analysis of GOT and GPT using eight independent variables strongly suggested that serum transaminase level had significant correlation with sex, age, drinking, history of liver disease and HBs-antigen.
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  • Plasma alkaline phosphatase and experimental cholestasis of squirrel monkeys (Saimiri sciureus)
    Toshio YOSHIDA, Hiroshi SUZUKI, Hisao MIKI, Takuro SADO, Hiroshi SUZUK ...
    1977 Volume 18 Issue 12 Pages 913-918
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.913
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    We have attempted to cause cholestasis in squirrel monkeys by ligation of the common bile duct or by oral administration of alpha-naphthyl isothiocyanate (ANIT), and studied alteration of plasma alkaline phosphatase (ALP)isoenzymes following liver injuries.
    Bile duct ligation was associated with a markedelevation of plasma bilirubin, ALP and r-GTP. Proliferation of bile ductules in the liver was obvious at 14 days after treatment. An increased ALP activity in plasma migrated identically with hepatic ALP on polyacrylamide gel disc electrophoresis. However, a macromolecular ALP characteristic for extrahepatic cholestasis in humans was not clearly detected on agar gel electrophoresis.
    On the other hand, oral administration of ANIT 50 mg/kg daily for 14 days developed a massive hepatic lesion predominantly in parenchymal cells but not in bile ductules. A hydropic swelling of parenchymal cells was prominent in the liver, accompanied with a marked elevation of plasma GOT, GPT and bilirubin. An elevation of plasma ALP, however, was rather mild and isoenzyme pattern of ALP in plasma was without significant difference from that of control monkeys.
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  • Quantification of human serum ligandin by radioimmunoassay
    Masanoru TSURU, Masanori HIRANO, Kazuaki KAMISAKA, Haruo KAMEDA
    1977 Volume 18 Issue 12 Pages 919-924
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.919
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    A radioimmunoassay of the human serum ligandin was developed using rabbit antisera for ligandin purified from human liver. The normal value was 3.7±1.1 ng per ml, and higher values were obtained in the acute phase of various liver diseases. In patients with constitutional hyperbilirubinemia, the values were almost all within normal range. Serum ligandin concentrations and GPT activities were paralleled in acute and chronic hepatitis, but not in liver cirrhosis. These findings indicated that ligandinemia might be due to the release of ligandin from the damaged liver cells and that ligandin might not be involved in the impaired transfer mechanism of bilirubin in patients with constitutional hyperbilirubinemia.
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  • Studies on complement of sera with liver diseases
    Takao MORITO, Tomoe NISHIMAGI, Norio ONIZAWA, Naotoshi TAKEDA, Morio M ...
    1977 Volume 18 Issue 12 Pages 925-935
    Published: December 25, 1977
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.18.925
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    In measuring serum complement level of patients with liver diseases, higher levels than normal were observed in acute hepatitis, in which the levels decreased in a few week after onset. On the other hand, lower levels of complement were observed in both chronic hepatitis and liver cirrhosis, in which change of complement level was less.
    Complement components of C3 and C4 decreased in progress of the disease and these amoumts correlated with total complement levels.
    High levels of Clq were observed in liver cirrhosis and its amounts did not correlated with degree of liver damage.
    There was no correlation between serum immunoglobulin levels and serum complement levels observed.
    A phenomenon of dissociation of complement level between serum and plasma was observed in 7 cases of liver cirrhosis, 6 cases of chronic hepatitis and one case of acute hepatitis.
    Complement levels of these 14 cases were lower than that of other cases without dissociation. Among them, 5 cases showed the dissociation all through the period observed, whereas other 9 cases showed wide range of change in complement level and showed no dissociation at their higher levels of complement.
    No paticular histological findings nor disfunction except some abnormalities in serological findings were observed.
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  • Cell-mediated immune rpsponses to ethanol and hepatitis B surface antigen in chronic liver diseases
    Yasuhiro KATO, Jugoro TAKEUCHI, Keigo NISHIMURA, Tatsuho SUGIMOTO, Kun ...
    1977 Volume 18 Issue 12 Pages 936-942
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.936
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    To test whether ethanol could be immunologicaly responsible for the development of chronic liver disease, cell-mediated immune responses to ethanol and HBsAg were compared in patients with chronic liver diseases. The subjects were composed of 36 cases with chronic liver diseases without a history of drinking (group A), 19 cases with chronic liver diseases with a history of drinking (group B), 8 patients with normal livers with a history of drinking (group C), and 6 patients with normal livers and without a history of drinking (group D). The leucocyte migration test was carried out according to the method of Söbørg's. When ethanol was added to the medium, an inhibition of leucocyte migration was found in 16 cases in group A (44%) and 11 cases in Group B (58%). No positive reaction to ethanol was ob served in Group C and D. In chronic liver diseases, lymphocyte reactivity to ethanol tended to be higher in cases of HBsAg positive chronic active hepatitis with lobular disorganization. In HBsAg positive chronic liver disease, lymphocyte reactivity to HBsAg was higher than that found in HBsAg negative chronic liver diseases.
    These observations indicate that there is altered immune response to ethanol and HBsAg in some forms of chronic liver diseases.
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  • Studies on the mitochondrial and microsomal cytochromes in alcoholics liver
    Takenobu KAMADA, Nobuhiro SATO, Sunao KAWANO, Norio HAYASHI, Takashi K ...
    1977 Volume 18 Issue 12 Pages 943-949
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.943
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    The mitochondrial and microsomal cytochromes in human livers were studied in relation to the ethanol metabolism. For this purpose, a micromethod for determining the cytochromes content in small biopsy sample was developed. The results with 62 cases with a variety of liver diseases were as follows; 1) The liver cytochrome a3 content did not significantly change in the drinkers with chronic hepatitis (CH) as compared to that of the non-drinkers, while it slightly decreased in the case of liver cirrhosis (LC), 2) The cytochrome P-450 content significantly increased in the drinkers with CH(P<0.05), while no change was observed in the drinkers with LC, 3) the P-450/b5 ratio of non-drinkers' livers was found to be in linear correlation, while this ratio was variable in the drinkers. The results were discussed in view of the ethanol metabolism in the livers.
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  • A case of portal hypertension of vinyl chloride worker
    Yoshihiro TAKISHITA, Goro HISANO, Eiro TSUBURA, Kunihiko HARADA, Akio ...
    1977 Volume 18 Issue 12 Pages 950-957
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.950
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    A man, 38-year-old who had been a worker in the manufacture of polyvinyl chloride for 18 years and 9 months, was diagnosed as portal hypertension with splenomegaly and varices in the esophagus and stomach. Laboratory data revealed thrombocytopenia, increased ICG and BSP retension, and normal range of GOT, GPT and alkaline phosphatase. He had splenectomy and esophageal transection. Histologically surgical specimen of the liver showed marked portal fibrosis and interlobular fibrosis. Focal and mild sinusoidal dilatation with slight proliferation of sinusoidal lining cells were observed. Conspicuous chronic congestion with moderate fibrosis in the red pulp were observed in the resected spleen.
    Eight months after the operation, he had a intestinal resection for strangulation of the small bowel. But he died of renal failure and panperitonitis after the operation.
    Portal hypertension in this case was suggested to be closely related to long term exposure of vinyl chloride monomer.
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  • A case of hepatocellular adenoma associated with anabolic steroids therapy for aplastic anemia
    Yasuhiko OHTA, Toshio SHIKATA, Michiko FUGIU, Kazuo SHIRAKI
    1977 Volume 18 Issue 12 Pages 958-964
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.958
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    The patient, a 4 1/4-year-old girl, was diagnosed as aplastic anemia and treated for 2 1/3 years with androgenic anabolic steroids (Winstrol, Enarmon and Enarmon depot). She died of diabetic coma. At autopsy, a 2.0×2.0×1.5 cm sized tumor was found in the right lobe of the liver. This tumor was sharply demarcated from the surrounding tissue, but had no fibrous capsule. Histologically, it was divided irregularly with loose conective tissues and composed of mature hepatocytes, which were arranged in two-cell plates and partly in tubular structures. There was no histological evidence of viral hepatitis and cirrhosis. A diagnosis of hepatocellular adenoma was made and it was considered to be induced by androgenic anabolic steroids. In the past literatures, 16 cases of liver tumors due to androgenic anabolic steroids were reported. And recently there has been increasing number of reports concerning association between oral contraceptives and liver tumors. These kinds of steroids have similar chemical structure and the liver tumors induced by them have very similar histological pattern. However various terms were used for those lesions. Therefore, we reported the present case with some discussions.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1977 Volume 18 Issue 12 Pages 965
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.965
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1977 Volume 18 Issue 12 Pages 966-985
    Published: December 25, 1977
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.18.966
    JOURNAL FREE ACCESS
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