Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 20, Issue 2
Displaying 1-17 of 17 articles from this issue
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  • Pathological Study on Alcoholic Liver Diseases in High and Low Incidence Countries: Comparison between Cincinnati, U.S.A. and Tokyo, japan
    Tsutomu KARASAWA, Toshio SHIKATA, Tomoko KUSHIDA, Haruo KANEDA, Hitosh ...
    1979 Volume 20 Issue 2 Pages 115-123
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.115
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    To deliniate histopathological features of liver diseases seen in Japanese alcoholics, 130 Japanese alcoholic patients were studied in comparison with 238 American alcoholic cases.
    In Japan female alcoholic patients were extremely rare. Although all aspects of alcoholic liver disease did exist in Japan, typical cases of acute alcoholic hepatitis with alcoholic hyalins were remarkably smaller in number. In contrast to this, 46 percent of Japanese alcoholic patients had chronic hepatitis, and the incidence of multilobular cirrhosis was much greater in Japan with higher prevalence of hepatitis viruses.
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  • Study on organic anions binding with isolated liver surface membranes
    Munehiko TANNO, Hideo YAMADA, Chitose TOBARI
    1979 Volume 20 Issue 2 Pages 124-132
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.124
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    Plasma membranes were isolated from the rat liver by the differential centrifugation. Then the ability of plasma membranes to bind 35S-BSP or 131I-BSP was investigated in the presence of the serum protein.
    1) About 70% of 131I-BSP was bound to the isolated plasma membranes when approximately the same amount of serum protein and plasma membranes existed. This interaction showed an equilibrium process involving the association and the dissociation between BSP and plasma membranes and probably does not involve the enzymatic reaction since the binding occurred instaneously and no correlation was observed between temperature and binding process.
    2) Competitive inhibitions were observed between 131I-BSP and BSP and partly ICG. In contrast, cholic acid and rifampicin did not inhibit the binding of 131I-BSP to plasma membranes.
    3) Binding activity was also observed in kidney membranes sililar to that of liver plasma membranes.
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  • Quantitation of human acidic Z protein in various liver diseases
    Kazuaki KAMISAKA, Masanori HIRANO, Masanobu TSURU, Kenichi OKANO, Akir ...
    1979 Volume 20 Issue 2 Pages 133-138
    Published: February 25, 1979
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.20.133
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    Human acidic Z protein was quantitated by radioimmunoassay in sera and liver supernatant obtained from normal and patients with various liver diseases. Normal human sera contained 38±11 (S.D.) ng/ml of Z protein. The serum concentrations of Z protein were 157±140ng/ml in acute hepatitis, 66±45 in liver cirrhosis, 57+39 in chronic hepatitis, 15.9±13.1 in Gilbert's syndrome (9 pts), 11.8+12.6 in Dubin-Johnson syndrome (4 pts), 16.6±15 in Rotor-type hyperbilirubinemia (12 pts) and 50.2±16.8 in patients of delayed type of ICG clearance (5 pts), Serum Z protein values were statistically correlated with serum GOT (r=0.57) and GPT (r=0.51), but not correlated with serum bilirubin (r=0.16) and ICG retention rates (r=0.33). Liver Z protein concentrations were decreased generally in patients with acute and chronic liver diseases, and prominent decreases were observed in patients with constitutional hyperbilirubinemia.
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  • Effect of synthetic tripeptides on cell proliferation and protein biosynthesis of 3T6 cells and isolated rat hepatocytes
    Shogo IGARASHI, Noboru YANAIHARA, Toshio KANEKO
    1979 Volume 20 Issue 2 Pages 139-143
    Published: February 25, 1979
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.20.139
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    The effects of four synthetic tripeptides, lysyl-cysteinyl-histidine, histidyl-phenylalanyllysine, lysyl-cysteinyl-glycine and lysyl-tyrosyl-glycine on cell proliferation and protein biosynthesis in 3T6 cells and isolated rat hepatocytes were studied. The incorporation of 3Hproline into collagen newly synthesized by cultured 3T6 cells was increased with an addition of tripeptide. However, cell number did not show any significant change after 12 hour incubation. The rat hepatocytes were isolated by direct injection of 0.05% bacterial collagenase in Ca-free-Hanks solution, and incubated for 12 hours in Eagle's MEM containing 10% fetal calf serum. The cell number did not show significant increase as in the case of 3T6 cells. The intracellular protein increased by administration of tripeptide in the culture medium and incorporation of 14C-leucine in newly synthesized protein also increased. Sugar content in the hepatocyte did not show any significant change. The effect of lysyl-cysteinylhistidine and histidyl-phenylalanyl-lysine on protein synthesis seemed stronger than that of lysyl-cysteinyl-glycine and lysyl-tyrosyl-histidine.
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  • Patho-morphological studies on hepatocellular carcinoma
    A study on a mechanism of capsule formation and septum formation of tumor nodule
    Masayuki OKABE
    1979 Volume 20 Issue 2 Pages 144-156
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.144
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    Encapsulated hepatocellular carcinoma is said to be much more frequent in Japan compared with United States and South Africa.
    There are several articles about capsule formation in hepatocellula carcinoma (HCC), but its mechanism has not yet been understood. In this study, 132 autopsy livers and 7 resected livers bearing HCC, obtained at Pathology Department, Kurume University School of Medicine from 1971 to 1977, were examined.
    1) Capsule formation was seen in 81 of the 139 cases (58.3%).
    2) There was no difference in the frequency of capsule formation between cases with and without liver cirrhosis.
    3) In advanced cirrhosis with minute HCC, capsule formation was more frequent (84.6%).
    4) Capsule results from collapse and collagenization of reticulin fibers following disappearance of liver cells due to compression by expansive growth of tumor.
    5) In all of the cases with capsule formation, intranodular septal formation was seen. There are two possible mechanisms for intranodular septal formation. Most of septa are a result of capsule formation that follows expansive growth of tumor over the capsle. Another explanation is the formation of septa by the collision of tumors of differing histologic pattern.
    6) Among the 17 cases showing type II according to Nakashima's classification, two or three histologically different patterns were seen in the one nodule in 8 cases.
    7) Many arterics and portal veins are seen around the tumor capsule and some portal veins are flattend. Tumor receives blood supply via arteries and arterial branches around the capsule.
    8) The angioarchtectular makeup was different in each area separated by intranodular septa, their histologic patterns was also different.
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  • A Histological Study of Hepatocellular Carcinoma
    Obstruction of the Common Bile Duct by Intraductal Growth.
    Yasuya KUMAGAYA
    1979 Volume 20 Issue 2 Pages 157-163
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.157
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    There were 10 cases of hepatocellular carcinoma with intra-bile duct growth during the past 7 years, constituting 6.3% of the 158 autopsy cases. The average age of these cases was 58.5 years with a male to female ratio of 4. All of them were of the infiltrative type histopathologically, and none of them was of the expansive type according to our classification based on the growth mode. There was cirrhosis and gross invasion of tumor into the portal vein in all cases. Tumor growth was also seen in the hepatic vein in 6. Of the 10 cases, obstructive jaundice was the first presenting symptom in 3, in which obstruction of the biliary tract at the hilum by tumor and blood clot was demonstrated by autopsy. Histologically, the tip of the tumor thrombus was necrotic with bleeding, and it is believed that a blood clot formed by bleeding from the tumor thrombus.
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  • Ultrastructure of Human Hepatocellular Carcinoma-Fine Structure of Blood Spaces (Tumor Vessels)
    Tadashi ISOMURA
    1979 Volume 20 Issue 2 Pages 164-174
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.164
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    Eight operation speciemens of human hepatocellular carcinoma were examined electron microscopically with much attention to the fine structure of those blood spaces.
    Small gaps or fenestrations of endothelial lining cells of tumor vessels were found with difficulty but the appearance of intercellular junctions between these cells were commomly observed. Basement membrane-like substances were seen beneath the endothelial cells in continuous or discontinuous fashion.
    Cytoplasmic folds were developed, forming marginal folds at the junctions, and cytoplasmic organelles of endothelial cells, such as the rER, mitochondria, and pinocytotic vesicles, were prominent. These observations could represent findings of active transport of endothelial cells.
    Endothelial cells which were covered by pericytes or having cytoplasmic filaments in those cytoplasms were also seen. Subendothelial space contained moderate to many microvilli extended from hepatoma cells.
    All these ultrastructural alterations of blood spaces were differed from the normal fine structure of sinusoid.
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  • Specific cellular immunity in hepatocellular carcinoma
    Daizo KAN, Mami KAN, Michiko Kozu, Mikio NISHIOKA, Tadayoshi TAKEMOTO
    1979 Volume 20 Issue 2 Pages 175-179
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.175
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    In 25% of hepatocellular carcinomas, microcytotoxity assays of peripheral blood lymphocytes to human fetal cells were positive. These microcytotoxity assays were seemed to have positive results continuously for a long Period. In the end stages of hepatocellular carcinomas, it seemed to have positive cytotoxity in many cases. In chronic liver diseases, some patients had positive cytotoxity. In these patients, histological findings of liver showed active hepatitis or dysplasia of liver cells.
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  • Studies on Arterio-Portal Vein Shunt Demonstrated by Celiac Angiography in Hepatocellular Carcinoma
    Yoshikazu NAGASAKI
    1979 Volume 20 Issue 2 Pages 180-188
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.180
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    Selective celiac and superior mesenteric angiograms of 154 patients with hepatocellular carcinoma (HCC) were studied.
    Various size darterio-portal vein shunts (A-V shunts) were found in 87 cases (56%). First order or larger portal vein branches were opacified retrogradely in 51 cases (Type II).
    Second order or smaller portal branches were opacified antegradely in 36 cases (Type I).
    The frequency of varices was 50.9% in the without A-V shunt cases and 78.9% in the Type II A-V shunt cases, the difference being. significant.
    In survival time from onset and from the beginning of chemotheraphy, the differences are significant between the cases with Type II A-V shunt and those without A-V shunt.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1979 Volume 20 Issue 2 Pages 189
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.189
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1979 Volume 20 Issue 2 Pages 190
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.190
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1979 Volume 20 Issue 2 Pages 191
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.191
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1979 Volume 20 Issue 2 Pages 192
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.192
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1979 Volume 20 Issue 2 Pages 193
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.193
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1979 Volume 20 Issue 2 Pages 194
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.194
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1979 Volume 20 Issue 2 Pages 195
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.195
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  • [title in Japanese]
    1979 Volume 20 Issue 2 Pages 196-221
    Published: February 25, 1979
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.20.196
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