Kanzo
Online ISSN : 1881-3593
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ISSN-L : 0451-4203
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Volume 22, Issue 6
Displaying 1-20 of 20 articles from this issue
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  • Effect of glucagon-insulin infusion on a rabbit's model of acute severe hepatitis induced by D-galactosamine·HCl
    Yatsugi NODA
    1981 Volume 22 Issue 6 Pages 775-784
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.775
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    It is suggested that glucagon (G) and insulin (I) may have a synergistic effect in promoting hepatic regeneration. The effect of G-I infusion on a rabbit's model of acute severe hepatitis induced by D-galactosamine·HCl (Gal) was investigated from the view points of mortality rate, light and electron microscopic liver histology and serial changes of rapid turnover serum proteins (RTSP). Both of G (2mg/kg/24hr) and regular I (2u/kg/24hr) with glucose (8g/kg/24hr) were administrated intraveneously from the femoral vein for 48hr, immediately after injection of Gal (0.95/kg).
    1) By the treatment only with glucose, mortality rate was improved, but the histological findings of the liver and serial changes of RTSP were not improved.
    2) By the treatment with G-I and glucose, mortality rate, the histological findings of the liver and serial changes of RTSP were improved.
    From these results, it is suggested that G-I therapy may suppress the progression of hepatic injury and also accelerate the recovery of hepatic injury in acute severe hepatitis.
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  • Clinical significance of determination of serum bile acid in liver diseases
    Naomi TANAKA, Toshiaki OSUGA, Masao TORII, Toshitsugu ODA, Fumiko MASH ...
    1981 Volume 22 Issue 6 Pages 785-802
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.785
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    Total serum bile acids estimated enzymatic fluorimetrically elevated as sensitive as GPT in the experimental B-type hepatitis in chimpanzees. Increased serum bile acids levels were found only in samples taken from the patients with hepatobiliary disease among wide varieties of diagnosis. Fasting serum bile acids (F. TBA) correlated most closcly with serum bilirubin in various liver diseases (n=174) and found to be a more sensitive and nonspecific index of hepatocellular damage and cholestasis. Oral loading of 300mg ursodeoxycholic acid increased the diagnostic value of F. TBA in 90 cases with chronic liver diseases (chronic hepatitis, fatty liver and liver cirrhosis). Liver cirrhosis was proved in 26 out of 28 cases with over 30μM in F. TBA and 31 out of 32 cases with over 70μM in M. TBA. Frequency of abnormal rate of M. TBA was the highest, 92% among 14 conventional tests in chronic liver diseases and those of F. TBA, R15ICG and GOT were 83%, 70% and 66% in the order. It is concluded that F·TBA and M. TBA determinations are the most sensitive test for liver function.
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  • Study of the seroconversion from e-Ag to e-Ab by corticosteroid treatment in the HBs positive chronic hepatitis
    Hiromitsu KUMADA, Eiji OYAKE, Kenji IKEDA, Akira YOSHIBA, Kikue FUJISA ...
    1981 Volume 22 Issue 6 Pages 803-813
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.803
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    In 6 chronic hepatitis patients who had been seropositive for both HBeAg and HBsAg, the seroconversion from HBeAg positive to anti-HBe positive was induced by the rebound phenomenon of serum transaminase caused at the end of corticosteroid medication or during its gradual reduction. All of the 6 patients had been given 30 to 40mg of steroid medicine daily while they had been seropositive for HBeAg and maintained a high level of serum transaminase. Subsequently the dose had been gradually reduced over periods ranging from 2 months to 1 year. When the serum HBeAg titer had dropped to 28 to 210 and the serum transaminase had been stabilized at less than 100u., steroid medicine administration was stopped and seroconversion was observed following the rebound phenomenon caused by this discontinuation.
    In one of the patients HBsAg became negative even in the radioimmunoassay at 14 months after the seroconversion into anti-HBe positive, and at 6 months following this anti-HBs also appeared in the serum.
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  • Relationship of reduced suppressor T lymphocyte activity to the delayed healing of acute viral hepatitis
    Katsuaki SUGIURA, Yasushi HASUMURA, Jugoro TAKEUCHI, Junichi YATA
    1981 Volume 22 Issue 6 Pages 814-819
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.814
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    The suppressor T cell function was studied in 12 patients with acute viral hepatitis by estimating concanavalin A-induced suppressor T cell activity (ConASA) on Pokeweed mitogen induced immunoglobulin production. According to ConASA, patients were separated into two groups: 2 patients with low response, and 10 patients with normal or high response. Between two groups, no difference was observed with respect to the etiological virus, serum transaminase levels, serum immunoglobulin levels and serum autoantibodies. However, all patients with low response showed periportal inflammation in their livers and prolonged courses of acute hepatitis.
    Therefore, the reduced suppressor T lymphocyte activity of patients with acute viral hepatitis seemed to be related to course of acute hepatitis.
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  • Studies of HBe-antigen and HBe-antibody in the 155 patients with persistent positive hepatic diseases caused by the HBs antigen. -seroconversion from HBe-antigen to HBe-antibody
    Hiromitsu KUMADA, Akira YOSHIBA, Eiji OYAKE, Kenji IKEDA, Ikuko WAKABA ...
    1981 Volume 22 Issue 6 Pages 820-826
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.820
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    HBeAg and anti-HBe in 155 patients, who had been HBsAg carriers and had already been diagnosed histologically, were tested by the Micro Ouchtelony method. Among 128 male patients, 25 (19.5%) were positive for HBeAg, 78 (61.0%) were positive for anti-HBe and 25 (19.5%) were negative for both. Among the 27 female patients, 7 (25.9%) were positive for HBeAg, 13 (48.1%) were positive for anti-HBe and 7 (25.9%) were negative for both. In comparison with histological diagnosis, HBeAg was positive mainly in patients with CH (2A) and CH (2B), the number in which it was positive being 16 (31.3%) for CH (2A) and 8 (34.8%) for CH (2B). On the other hand, anti-HBe was noticeably positive in the patients with CH (1), LC and HeP.
    The seroconversion from HBeAg positive to anti-HBe positive was observed in 17 patients which included 13 males and 4 females, whose age range consisted of 2 in their 20s, 8 in their 30s, 5 in their 40s and 2 in their 60s. At the time of seroconversion, the serum transaminase level rose to more than 100 u. in 15 patients (85.7%). As for the histological diagnosis of 17 patients, chronic persistent hepatitis was diagnosed in 1, chronic aggressive hepatitis (2A) in 8, chronic aggressive hepatitis (2B) in 7 and liver cirrhosis in 1.
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  • Fulminant hepatitis with findings of chronic hepatitis histologically
    Hideshi KOMORI, Masatoshi KUDO, Katsuhiko FUJIMI, Shusuke TOMITA, Yosh ...
    1981 Volume 22 Issue 6 Pages 827-836
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.827
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    Twelve cases of fulminant hepatitis were investigated histologically.
    Of these 7 cases dead and were autopsied.
    Three of the 7 autopsied cases showed portal lymphocellular infiltration and fibrosis inclusive of massive liver cell necrosis.
    These 3 cases were not differed from the other 4 cases of typical fulminant hepatitis in physical findings, laboratory findings on admission, and clinical courses.
    Past history of liver dysfunction was present in all of the 3 cases.
    These 3 cases were considered to have acute hepatic failure based on chronic hepatitis.
    Five cases wcre survived and biopsied after recovery.
    Three of the 5 cases showed chronic active hepatitis laparoscopically and histologically.
    Past history of liver dysfunction was revealed in 1 case of the 3.
    In follow-up studies of the other 2 cases, transaminases were increased again 2-4 months after recovery.
    These 2 cases might become infected with another viral hepatitis owing to transfusion during fulminant hepatitis and resulted in chronic hepatitis.
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  • Pancreatic endocrine function in chronic liver diseases; Plasma insulin, C-peptide and glucagon responses to intravenous administration of arginine
    Nobuyoshi OKUMURA, Tetsuo HAYAKAWA
    1981 Volume 22 Issue 6 Pages 837-847
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.837
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    Pancreatic endocrine function was studied in 30 patients with liver cirrhosis, 25 with chronic hepatitis and 11 healthy controls. The results obtained were as follows: 1) Significantly higher values of basal plasma insulin (IRI) and C-peptide (CPR) were observed in cirrhotics than in controls. Following arginine infusion, IRI response was greater in the liver diseases than in controls, but CPR response was not. 2) Basal and arginine stimulated plasma glucagon values (IRG) were significantly higher in the liver diseases than in controls.3) Fasting values and increments of IRG in the liver diseases were correlated with BSP retension rate, and inversely correlated with ICG disappearance rate. 4) Metabolic clearance rate and half disappearance time of exogenous glucagon in cirrhotics were similar to those in controls.
    These findings indicate that pancreatic β cell function in chronic liver diseases increases in the basal state but is normal during arginine stimulation despite the presence of hyperinsulinemia, and that α cell hyperfunction both in the basal state and during arginine stimulation results in hyperglucagonemia. Glucagon secretion may increase as fibrosis or inflammatory infiltration of the liver progresses.
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  • Survival rates and causes of death in various liver diseases
    Hiroyasu HIRAKAWA
    1981 Volume 22 Issue 6 Pages 848-858
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.848
    JOURNAL FREE ACCESS
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    The survival rates and causes of death were analysed in 1, 536 patients with liver diseases (1, 471 cases of acute hepatitis, chronic hepatitis and liver cirrhosis diagnosed by peritoneoscopy and histology, and 65 cases of decompensated liver cirrhosis diagnosed by clinical course and autopsy). The 10 year survival rates were 95.9% in acute hepatitis, 94.7% in chronic persistent hepatitis (CPH), 91.1% in chronic aggressive hepatitis activity moderate (CAH-2A), 89.1% in chronic aggressive hepatitis activity severe (CAH-2B) and 49.0% in liver cirrhosis. For CAH-2B, the death rate increased rapidly after 10 years to parallel the early phase of the survival curve for liver cirrhosis. The 50% survival time was 9.8 years for compensated liver cirrhosis and 2.1 months for decompensated liver cirrhosis. Defferences in sex, alcohol intake and steroid treatment were unrelated time for liver cirrhosis. Patients with acute hepatitis or CPH rarely died from liver disease, but patients with CAH-2B or liver cirrhosis usually did.
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  • Prevalence of HBeAg & HBeAb in the patients with primary hepatocellular carcinoma
    Yoshihiro FUKUDA, Tsunehisa KAWASAKI, Masami MIYAMURA, Tomoyuki SUGIYA ...
    1981 Volume 22 Issue 6 Pages 859-865
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.859
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    We looked for the prevalence of HBeAg and HBeAb in the patients with primary hepatocellular carcinoma (HCC) by radioimmunoassay (Abbott Laboratories) and compared the results in asymptomatic carrier (ASC), chronic hepatitis (CH) and liver cirrhosis (LC).
    Twenty-four of 61 (39%) patients with HCC were positive for HBeAg and 19 (31%) were positive for HBeAb.
    The positive frequency of HBeAg in the patients over 50 years old were 0% in ASC, 10% in CH, 42% in LC and 35% in HCC.
    We have done the retrospective determination of HBeAg and HBeAb in sera from 7 patients with HCC who were followed as liver cirrhosis for more than 3 years.
    Five of 7 patients persisted HBe-antigenemia throughout their clinical course and 2 of 7 persisted HBe-antigenemia until about 1.5 years and 2 months before occurrence of HCC respectively.
    These findings suggest that the patients with persistent HBeAg positive CH may develop to LC and associate to the occurrence of HCC, so careful clinical observation must be done in the older patients with HBeAg positive LC such as serial detection of alpha-fetoprotein.
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  • Significance of Mallory bodies in the non-neoplastic liver tissue of hepatocellular carcinoma
    Yasuni NAKANUMA, Goroku OHTA
    1981 Volume 22 Issue 6 Pages 866-872
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.866
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    Occurrence of Mallory bodies in hepatocytes of the non-neoplastic liver tissues of hepatocellular carcinoma (HCC) of 95 cases and of the livers of 68 cases without HCC was examined. Mallory bodies were found in the non-neoplastic liver tissues of HCC of alcoholics (31.3%) as well as of the non-alcoholics (26.6%). In the non-alcoholics, Mallory bodies were more frequent in the non-neoplastic cirrhotic livers with HCC (34%) than in the cirrhotic livers without HCC (12.9%). In the non-alcoholics with HCC, Mallory bodies were more frequent in livers with cirrhosis (34%) than in those with less regenerating and well preserved hepatic lobules (0%). Furthermore, Mallory bodies in HCC cells were more frequent in the cases with Mallory bodies in the non-neoplastic liver tissues than in cases without. These findings might suggest that occurrence of Mallory bodies in the non-neoplastic tissues in the cirrhotic livers, whether from the alcoholics or not, was related with presence and occurrence of HCC.
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  • Effect of anti-AFP antibody on AFP-producing human hepatoma
    Kunihiko MANABE
    1981 Volume 22 Issue 6 Pages 873-881
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.873
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    The effect of anti-human AFP horse serum on the established AFP-producing human hepatoma serially transplanted in nude mice was investigated. The hepatoma tissue was inoculated subcutaneously in nude mice. The administration of the sera was performed by subcutaneous and intratumor injection. In the other group, the tissue was inoculated subcutaneously after incubation in the sera.
    The inhibition of the growth of the tumor transplanted in nude mice was recognized after administration of the antisera. This phenomenon was obvious in the early period of the administration. The remarkable decrease in serum AFP levels of nude mice was observed, especially in AFP-high-producing tumor.
    Histopathologically the tissue destruction, degeneration of the hepatoma cells or cellular infiltration were not noticeable.
    A functional or biochemical disorder due to the conjugation of anti-AFP antibody with AFP-producing cell was considered as a mechanism of the inhibition.
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  • A survival case of fulminant hepatitis following second exposure to halothane at the interval of 7 months
    Itsue YAMASAKI, Ryokichi NODA, Manabu GOMYODA, Yutaka HORIE, Hironaka ...
    1981 Volume 22 Issue 6 Pages 882-888
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.882
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    A 36-year-old female patient with halothane-induced fulminant hepatitis was reported. The predominant clinical features were characterized by fever, marked jaundice, decrease in hepatic dullness, ascites, gastrointestinal bleeding and disseminated intravascular coagulation. She was treated with fresh blood transfusion, platelet rich plasma, reduced glutathione and intravenous hyperalimentation and recovered fully. The liver biopsy showed chronic aggressive hepatitis (severe). It is suggested that a halothane-induced hypersensitivity reaction remains longer than that in the previous reports.
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  • Clinical course of type B chronic hepatitis simultaneously infected with type A acute hepatitis
    Yutaka HORIE, Hiroshi YOSHIDA, Tomonori IMAOKA, Yukihiro KISHIMOTO, Ta ...
    1981 Volume 22 Issue 6 Pages 889-894
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.889
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    A wife aged 33 with HBs antigen positive chronic hepatitis simultaneously suffered from acute hepatitis type A, one month after the husband had infected with acute hepatitis type A. In the wife and husband, there was a sudden onset of fever associated with increase in serum TTT, IgM level and atypical lymphocytes in peripheral blood. Infection with acute hepatitis type A was confirmed by detection of IgM type hepatitis A antibody using HAVAB-M kit. It is suggested that titer of HBs antigen in this wife transiently decreased by simultaneously infection with type A virus.
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  • Liver injury in patients with typhoid fever
    Tatsuro WADA, Toyoaki MAEYAMA, Yasuo MAJIMA, Ryukichi KUMASHIRO, Masat ...
    1981 Volume 22 Issue 6 Pages 895-900
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.895
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    We examined liver function tests in fourteen patients with typhoid fever, and liver histology from two of these patients.
    By clinical presentation, all patients were anicteric and five patients were noted to have mild hepatomegaly. In liver function tests, serum transaminase levels were mildly or moderately elevated in eleven patients (78.3%). SGOT levels were higher than SGPT levels in almost all patients. Serum LDH levels were elevated in eleven patients and serum total cholesterol levels were reduced in six patients.
    In one patient, the liver histology showed mononuclear cell infiltration in portal tracts, liver cell focal necrosis, and hyperplasia of Kupffer cells. This resembled non-specific, reactive hepatitis. In the second patient, the liver histology showed mild, fatty degeneration of liver cells.
    SGOT, SGPT, SLDH, and total serum cholesterol returned to normal elevels in two to three weeks after chemotherapy.
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  • Two cases of hepatocellular carcinoma associated with hypoglycemia
    Isao FUJII, Hiromasa ISHII, Toshihumi HIBI, Fumio OKUNO, Yoshio MIZUNO ...
    1981 Volume 22 Issue 6 Pages 901-911
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.901
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    Two cases of hepatocellular carcinoma associated with spontaneous hypoglycemia are reported.
    The first case was 62y.o. male who had no previous history of liver disease. The diagnosis of hepatocellular carcinoma was established by selective celiac angiography combined with liver scintigram. The hypoglycemic attack developed at early stage of the clinical course and the patient died about 6 months after the first attack of hypoglycemia.
    The second case was 57y.o. female with past history of lupoid hepatitis 10 years prior to the present illness. The patient was admitted to the hospital because of ascites and increased hepatomegaly and celiac angiography revealed hepatic malignancy. The hypoglycemic attack occured at terminal stage and died 3 weeks after the onset of hypoglycemia.
    In either case, serum IRI level was not elevated with normal level of IRI or ILA in hepatoma tissues.
    we also reviewed 112 cases of hepatocellular carcinoma thus far reported in Japan and the pathogenesis of tumor induced hypoglycemia was discussed.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1981 Volume 22 Issue 6 Pages 912
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.912
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1981 Volume 22 Issue 6 Pages 913
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.913
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1981 Volume 22 Issue 6 Pages 914
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.914
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1981 Volume 22 Issue 6 Pages 915
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.915
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  • [title in Japanese]
    1981 Volume 22 Issue 6 Pages 916-923
    Published: June 25, 1981
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.22.916
    JOURNAL FREE ACCESS
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