Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 23, Issue 7
Displaying 1-19 of 19 articles from this issue
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  • Serum C1q levels in patients with various liver disease
    Kiyonori ARAKI
    1982 Volume 23 Issue 7 Pages 707-714
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.707
    JOURNAL FREE ACCESS
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    The serum C1q level was high in patients with acute hepatitis and hepatic cell carcinoma whose CH50 level was high, and in patients with chronic aggressive hepatitis and liver cirrhosis. In patients with chronic persistent hepatitis, the serum C1q level was within normal range. During an acute exacerbation of a patient with CAH(2B), the serum C1q level slightly decreased before and after the peak of SGPT. In patients with chronic aggressive hepatitis and liver cirrhosis, high serum C1q levels were associated with either low CH50 levels or low C3 levels and low C3 activator levels.
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  • Comparative study of patients surviving fulminant liver failure
    Makoto YOSHIBA, Takahiro SAKAI, Takemasa SANJO, Noboru INOUE, Zenya YA ...
    1982 Volume 23 Issue 7 Pages 715-721
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.715
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    The details of clinical course, clinical manifestations and laboratory findings of 12 surviving patients were compared with those of 25 dead patients, in order to know what data indicates prognosis and substantial severity of fulminant liver failure accurately. Interval between onset of the disease and that of coma and duration of coma were shorter, and plasma total amino acids level was lower in the surviving patients. However, there was no difference
    in coma grade, prothrombin time (PT), serum total bilirubin value (T. Bil.) and serum transaminase level (GOT, GPT) between survivors and the dead. Survivors who were treated with chacoal plasma perfusion or plasma exchange recovered from coma more rapidly after first performance of
    these treatment than the dead, though their coma was as deep as that of the dead. These observations suggest that coma grade as well as PT, T. Bil., GOT and GPT hardly give informations about prognosis and substantial severity of rapidly developing fulminant liver failure, and that they should be determined based on more reliable markers such as plasma total amino acids level.
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  • An epidemic of viral hepatitis type A in the southern part of Tokushima prefecture: Clinical studies
    Kazuhiko MASUDA, Hiroshi FUJIMOTO, Tadashi HAYASHI, Machiko KOMATSU, T ...
    1982 Volume 23 Issue 7 Pages 722-730
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.722
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    An epidemic of hepatitis type A, as confirmed by determination of antibody to hepatitis A virus, occurred from November 1979 to April 1980 in the southern part of Tokushima prefecture. Among 49 patients seen by us, adults aged 20' through 50' predominated and the male: female ratio was about 3. Familial cases were observed in 6 pedigrees. The route of infection was not elucidated, though water-borne epidemic was excluded.
    High fever, vomiting and headache were noted in high frequency. Absolute lymphocytosis was seen in 6 cases, and more than 5% of atypical lymphocytes was found in 10 cases. The level of IgM was elevated in all cases except one, and IgG and IgA were elevated remarkably in a few cases.
    The period required for GOT and GPT to normalize averaged 55.4 and 64 days, respectively, and 6 cases needed more than 100 days. Three of the six cases were alcoholics, and two of the three also had diabetes mellitus and developed cholestatic form of hepatitis, which was followed by elevation of GOT and GPT
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  • Clinical significance of HBeAg/anti-HBe system in HBsAg positive chronic hepatitis
    Takeshi SODEYAMA
    1982 Volume 23 Issue 7 Pages 731-741
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.731
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    The clinical significance of HBeAg/anti-HBe in HBsAg positive patients with chronic hepatitis was investigated. Seventy patients with HBsAg positive chronic hepatitis documented by liver biopsy were followed up for 24 to 74 months with serial examination of HBsAg (R-PHA), HBeAg and antiHBe (immunodiffusion and radioimmunoassay).
    Of 43 cases initially positive for HBeAg, 27 had remained HBeAg positive during the follow-up period, and 16 eventually lost HBeAg, 9 of whom seroconverted to anti-HBe. Of 23 cases initially positive for anti-HBe, 21 had remained anti-HBe positive and 2 had lost this antibody, but one of these 2 patients had become positive for HBeAg.
    As regards biochemical and histologic prognosis of chronic hepatitis, the patients who had remained HBeAg positive continued to have elevated S-GPT levels and worsened in histologic features on repeated liver biopsies, whereas most of those with persistent anti-HBe showed a regression of biochemical and histological abnormalities.
    Seroconversion from HBeAg to anti-HBe appeared to occur prevaillingly in young and female patients who had showed histologic findings of chronic hepatitis with no lobular disorganization. Most of the seroconverted cases showed high titer anti-HBe and lower to normal s-GPT levels, but some of them whose anti-HBe titer had remained low continued to have a high s-GPT levels even after seroconversion in HBeAg/anti-HBe system.
    These results indicate that the persistence of HBeAg in HBsAg positive chronic hepatitis is a predictable significance in evaluating the prognosis of the liver diseases, and furthermore, it is very important, in the same aspect of views, to estimate whether the seroconversion in HBeAg/anti-HBe system has occured either in the stage of chronic hepatitis or after the development of cirrhosis.
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  • Clinical significance and characterization of circulating immune complexes in various liver diseases
    Kiyonori ARAKI
    1982 Volume 23 Issue 7 Pages 742-749
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.742
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    A Clq binding test was used for the detection of circulating immune complexes (CIC) in various liver diseases. The CIC level was relatively high in patients with chronic aggressive hepatitis and liver cirrhosis. The study of the sedimentation rate of CIC in various liver diseases showed two kinds of CIC; one with greater sedimentation rate and the other with smaller one. During acute exacerebation of chronic active liver diseases, the CIC level reached its peaks 1 to 5 weeks before and after the peak of SGPT. In acid buffer, CIC in one patient with HBsAg positive CAH(2B) was dissociated into 5 or 6 fractions by SDS-PAGE technique. The two of these fractions proved to be HBsAg and IgG. During the acute exacerbation of this case, the fraction pattern of CIC by SDS-PAGE technique was similar to each other at any of the four stages and HBsAg always composed one of the antigens.1) Zubler RH, Lange G, Lambert PH, et al: Detection of immune complexes in unheated sera by a modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol 116: 232-235, 1976
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  • Large dose glycyrrhizin treatment in HBsAg positive chronic liver disease, Its effect on HBV
    Osamu YOKOSUKA, Masao OMATA, Yoshimi ITO, Katsuo UCHIUMI, Junko MORI, ...
    1982 Volume 23 Issue 7 Pages 750-759
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.750
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    Large dose Glycyrrhizin (SNMC) treatment was given on 12 HBsAg positive chronic hepatitis patients. Serum GPT, GOT levels decreased after SNMC treatment and histological examination also demonstrated the improvement in cell infiltration and hepatocyte degeneration. Sequential analysis of DNA-polymerase revealed its elevation during the latter half of the treatment and its reduction after the treatment. Movement of HBsAg titer was similar to that of DNA-p. Increase in HBV particles during the treatment was confirmed by electron-microscope. Immunoperoxidase examination of tissue HBcAg revealed the increment of this antigen. In 5 of 9 HBeAg positive patients, HBeAg turned negative (56%) during the follow up period. Seroconversion to anti-HBe occurred during the treatment in only 1 patient and 4 others became HBeAg negative (3 seroconversion) at the time of reexacervation of transaminase long after the discontinuation of the treatment. These results suggest that overall pharmacological action of SNMC is analogous to that of glucocorticoid.
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  • Electron microscopic examination of Mallory body
    The ultrastructural appearance of Mallory body and the interaction between Mallory body and surrounding inflammatory cells
    Masafumi KOMATSU, Fumio TOBORI, Hitoshi YAGISAWA, Yoshiro INOUE, Tsuyo ...
    1982 Volume 23 Issue 7 Pages 760-768
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.760
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    The ultrastructural appearance of Mallory body in hepatocyte and the interaction between Mallory body and surrounding inflammatory cells were investigated in 7 cases with alcoholic hepatitis and a case with hepatocellular carcinoma.
    According to the classification of Yokoo et al, 3 types of Mallory body variations were observed in hepatocyte and bileduct epithelial cell, but two kinds of different filamentous structure in Kupffer cells were found in the present series. There were ribosome, rough endoplasmic reticulum, mitochondria, microtubule, intermediate filament in and around Mallory body, but the transitional features of Mallory body into intracellular organella did not reveal. Small sized Mallory body was composed of intermediated filament about 100Å in diameter.
    The inflammatory cells, such as neutrophil, monocyte and lymphocyte, and Kupffer cell were frequently attached to or infiltrated into the Mallory body in hepatocyte. The findings in present series were very similar to those of lymphocytocytotoxicic reaction observed by Sanderson. Therefore, the finding in present series were suggested the possible immunologic mechanism of the development of alcoholic hepatitis.
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  • In vivo oxygen consumption in the liver of patients with chronic liver diseases
    Norio HAYASHI, Nobuhiro SATO, Mitsunori SAITO, Yutaka KISHIDA, Akinori ...
    1982 Volume 23 Issue 7 Pages 769-773
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.769
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    In vivo oxygen consumption in the livers of patients with chronic liver diseases was studied by reflectance spectrophotometry during peritoneoscopy. The results were as follows; 1) In vivo oxygen consumption (VO2) significantly decreased in liver cirrhosis as compared to those in chronic hepatitis, and VO2 was correlated with the difference in absorbance between 569 and 650 nm. 2) VO2 was correlated with serum albumin and R15 ICG. 3) VO2 did not necessarily correlate with the oxygen consumption of liver slices measured in the O2-electrode apparatus.
    Therefore, the reduction of in vivo oxygen consumption in the liver was considered to be not due to the reduction of respiratory activity of liver itself, but due to the reduction of blood supply.
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  • Experimental studies on descending infection of biliary tract
    Akio HANAOKA
    1982 Volume 23 Issue 7 Pages 774-781
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.774
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    The mechanism of ascending infection of biliary tract from the intestinal canal has been generally accepted. However, the possibility of the descending infection through the portal system has also been conjectured.
    The present study was designed to confirm whether the possibility of the mechanism of descending infection in the biliary tract through the portal system is really present or not.
    As the experimental animals Wister strain rats were used and E. coli in various consentrations were injected from portal vein, then, culture of drained bile, and histological study of the liver were carried out.
    The results obtained are as follows: In bacteriological study E. coli was detected in the bile, 7 hours after injection of the bacteria only when 1×108 was injected into the portal vein. In the light and electron microscopic studies, E. coli was found in the Kupffer cell, Disse's space and in the liver cell.
    The destruction of liver cells and inflammatory cell reaction caused micro-abscesses in the liver, which might result in invasion of E. coli from the portal vein to the biliary tract.
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  • Clinical studies of minute hepatocellular carcinoma
    Satoshi NAKANO, Takashi KUMADA, Hirosato OHTA, Hajime WATAHIKI, Isao T ...
    1982 Volume 23 Issue 7 Pages 782-791
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.782
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    Clinical studies were carried out on 18 cases of minute hepatocellular carcinoma and the results obtained are summerized as follows.
    1) No special signs and symptoms were obtained. 2) Serum levels of AFP and ferritin were positive in 50% and 39% respectively. Combinations of the both tumor markers determination enhanced the diagnosis to 83%. 3) The lesions were detected as homogenous, round or oval shaped, low density area in almost all of them as CT scan image. 4) As for ultrasonography, all of them were detected as nodule lesions and the echo level changed from low echo to high echo depending on the size of the tumor. 5) Tumor stain and coronary lucent rim were obtained in 83% and 25% respectively in angiography. 6) Diagnostic rates of respective examinations were 89% in CT, 82% in US and 88% in angiography. 7) Seven of 10 cases, examined histologically, belonged to class 1 or 2 in Edmondson & Steiner's classification.
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  • Studies on the mechanism of hypercholesterolemia in patients with hepatocellular carcinoma
    Tatsuro WADA
    1982 Volume 23 Issue 7 Pages 792-801
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.792
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    Serum lipids and bile acid concentrations were measured in 44 patients with hepatocellular carcinoma (HCC) and 30 patients with liver cirrhosis (LC). HCC was classified into two groups according to serum total cholesterol levels. Group I was hypercholesterolemic group (>230mg/dl), and Group II, the remainder of HCC patients.
    Total cholesterol levels were higher in HCC than in LC. Serum squalene levels, precursor of cholesterol, were higher in Group I than in Group II and LC (Group I>Group II>LC). Serum squalene levels correlated with total cholesterol in patients with HCC (r=-0.57, p<0.05).
    Serum and biliary bile acid levels were similar in these three groups. Serum bile acid levels did not correlate with cholesterol levels.
    Serum HDL-cholesterol levels, large components of bile acid precursor, were lower in Group I than in Group II and LC (Group I<Group II<LC). And serum HDL-cholesterol levels were negatively correlated with total cholesterol levels in HCC (r=-0.52, p<0.05).
    These data suggested that the mechanism of hypercholesterolemia in HCC may be explained by an increased production of cholesterol and a reduced production of bile acid from cholesterol.
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  • A case study of surgically resected malignant hemangioendothelioma of the liver in adult with special reference to
    ultrastructural observation
    Takafumi ICHIDA, Kazuhiko SHIMADA, Takashi KOJIMA, Kyoich INOUE, Hiros ...
    1982 Volume 23 Issue 7 Pages 802-810
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.802
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    50 years old male who had no history of thorotrast injection, inhalation of vinyl chloride and another specific causes was admitted to the hospital because of epigastrial discomfort. Despite almost normal liver function test, left hepatic tumor was detected by hepatic scintillation and ultrasonography. Hypovascular tumor was demonstrated by computed tomography and selective celiac angiography.
    Resected tumor was 760gr in weight and 15×11×9cm in size and gray, milky coloured. Histology of the resected tumor showed fibrosarcomatous features. Reticulin fiber invaded into the tumor cell groups at randomly. In electron microscopic observation, atypical shaped tumor cells were gathered in compact and lack of lumen. Basement membranes were found in some areas. In tumor cells, nuclei were bizaar formed and only a few organelles were found in cytoplasm. Few tight junctions and no Weibel-Palade bodies were found.
    After successful resection of the tumor, the post operative course was uneventful and he is in good health 1 year after the operation.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1982 Volume 23 Issue 7 Pages 811
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.811
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 7 Pages 812
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.812
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 7 Pages 813
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.813
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1982 Volume 23 Issue 7 Pages 814
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.814
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 7 Pages 815
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.815
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 7 Pages 816
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.816
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1982 Volume 23 Issue 7 Pages 817-853
    Published: July 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.817
    JOURNAL FREE ACCESS
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