Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 25, Issue 10
Displaying 1-24 of 24 articles from this issue
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  • Unusual filamentous structures in the hepatocytes of chimpanzees
    Mie HANAWA, Kenji ABE, Toshio SHIKATA, Yoshimitsu ISHIHARA, Kyousuke M ...
    1984 Volume 25 Issue 10 Pages 1227-1232
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1227
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    Filamentous structures were found within the dilated endoplasmic reticula of hepatocytes of two chimpanzees, during the effecacy testing of HB vaccine. Those chimpanzees were recieved blood transfusion of HBsAg positive carrier blood after HB vaccination. The structure was different from the filamentous structure of HBsAg and might be identical with that reported by Desmet. in 1982. They reported that these were specific for non-A, non-B hepatitis. In our cases, one chimpanzee was infected by hepatitis B virus (HBV) even though HB vaccination and the other didnot show any evidences of the onset of hepatitis.
    Of cause, it was not clear that HBV carrier blood also contained non-A, non-B virus or viruses. However, in one chimpanzees, the filamentous structures were observed 62 weeks after blood transfusion. Furthermore, two chimpanzees were generally weak due to tuberculosis and were treated with antituberculotic drugs during the experiment. The possibility of effect of the drugs for the occurrence of filamentous structure is also raised. It is concluded that the filamentous structure could not be necessarily specific to non-A, non-B hepatitis.
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  • Ultrastructural study on microvasculature of portal tract in chronic hepatitis
    With special reference to capillaries and ternnlinal arterioles
    Junichi SUDO
    1984 Volume 25 Issue 10 Pages 1233-1245
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1233
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    The ultrastructure of capillaries and terminal arterioles in the portal tract of the liver was studied in 15 patients (CPH, CAH 2A and CAH 2B in five patients respectively), and compared with normal controls. In each case, the diagnosis was established on clinical, biochemical and histological basis. Specimens for histological examination were obtained from needle biopsy under peritoneoscopy.
    Capillaries in chronic hepatitis were divided into three groups morphologically. Type 1 capillary was generally of normal structure. Type 2 was a newly formed capillary composed of immature endothelial cells and pericytes, which was usually located at the periphery of the portal tract. Type 3 was characteristic of those swollen endothelial cells with scarce cell organelles that resulted in various degrees of obstruction of the capillary lumen. This capillary was found in the center of the portal tract in the vicinity of the terminal arteriole whose endothelial cells show the same change as those seen in Type 3 capillary.
    Capillaries and terminal arterioles in CPH were similar to those seen in control liver and belonged to Type 1 capillaries with terminal arterioles intact. On the other hand, capillaries and terminal arterioles in both CAH 2A and 2B were usually composed of Type 2 and 3 capillaries and terminal arterioles with swollen endothelial cells. Furthermore, there was a significant decrease in number of capillaries in the portal tract tissue in both CAH 2A and 2B, but no remarkable change in CPH.
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  • A clinicopathological study of female patients with alcoholic liver disease
    Masanobu NISHIMURA, Toshihiko NOUCHI, Wataru KOYAMA, Namiki IZUMI, Shi ...
    1984 Volume 25 Issue 10 Pages 1246-1252
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1246
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    A clinicopathological study was performed in 25 female (F) patients with alcoholic liver disease. The results were compared with those in male (M) patients with alcoholic cirrhosis and female patients with non-alcoholic cirrhosis. Of the female alcoholics with liver disease, 20 patients (80%) had severe alcoholic liver diseases such as alcoholic cirrhosis, alcoholic hepatitis and alcoholic hepatic fibrosis. There were significant differences in mean age (F:M=43.6:49.5 years old), mean duration of alcohol abuse (F:M=16.8:26.8 years) and the mean total amount of alcohol consumed (F:M=587:1014Kg) between the female and male patients with alcoholic cirrhosis. Almost half of the females had an abnormal menstrual history, such as irregular menstruation and amenorrhea, which appeared concomitantly with severe alcohol abuse and exacerbation of the liver disease. These results suggest that women are more susceptible than men to the development of alchoholic cirrhosis. Abnormalities in sex hormone controls observed in female alcoholics may contribute, at least in part, to the progression to alcoholic cirrhosis.
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  • Efficiency of intravenously infused maltose for energy supply in patients with liver injuries
    Takero IDE, Kazuhisa TAKETA
    1984 Volume 25 Issue 10 Pages 1253-1259
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1253
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    The efficiency of an intravenously infused isotonic maltose solution for energy supply in patients with acute hepatitis and liver cirrhosis and in healthy controls was studied by measuring the blood levels and urinary loss of maltose and glucose after infusion of 500ml of 10% maltose or glucose solution in 2 hours followed by 2 hour urine collection.
    Urinary loss of maltose, including the loss as glucose, was 36.0% in the control group, 16.2% in acute hepatitis and 18.8% in liver cirrhosis. The amount of maltose utilized in the body was thus much greater than that of glucose infused as an isotonic solution (500ml of 5% glucose solution) during the same period of time. The alterations of blood metabolites, lactate, pyruvate, uric acid and inorganic phosphate, following maltose administration were similar to those following glucose administration, except for much smaller rises in blood glucose level. These results indicate the usefullness of 10% maltose solution for intravenous supply of energy for patients with liver injuries.
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  • Hepatic copper concentrations in various liver diseases
    Yasuyuki YAZAKI
    1984 Volume 25 Issue 10 Pages 1260-1272
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1260
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    Liver-copper concentrations were estimated in 338 patients (337 liver biopsy and 1 necropsy of Wilson's disease) with various liver diseases except obstructive jaundice by neutron activation analysis. Levels of greater than 150μg per g. dry liver weight(μg/g·dw)were found in the patients with Wilson's disease, primary biliary cirrhosis (PBC), posthepatitic hyperbilirubinemia, fatty liver due to obesity, acute hepatitis, chronic hepatitis, liver cirrhosis, and Dubin-Johnson's syndrome.
    Greater hepatic copper levels more than 100μg/g·dw were found in 30% (6120) of patients with fatty liver due to obesity. The high hepatic copper levels were decreased with improvement of fatty liver in four patients out of ten who had been treated by low caloric diet therapy. In PBC, the large socondary lysosomes frequenthy appeared around the nucleus when hepatic copper level has exceeded 200μg/g·dw.
    Copper was detected in the granules contained in the large secondary lysosomes by X-ray microanalysis.
    Organelles in the hepatocyte were intact when the lysosomal membrane of this large secondary lysosomes was normal.
    In chronic hepatitis, chronic active hepatitis showed greater hepatic copper levels than those of chronic inactive hepatitis (p<0.01).
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  • Evaluation of hepatic function by computer analysis of 99mTc-N-pyridoxyl-5-methyltryptophan dynamic curves
    Toru KASHIWAGI, Masayoshi AZUMA, Hiroyuki MATSUDA, Hiroaki YOSHIOKA, H ...
    1984 Volume 25 Issue 10 Pages 1273-1280
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1273
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    A new analytical method was developed for 99mTc-N-pyridoxyl-5-methyltryptophan (99mTc-PMT) dynamic curves in the heart and liver using computer. Four parameters were obtained: 99mTc-PMTdisappearaRceratefromplasma(Kd), hepaticuptakerate(Ku), hepatic excretion rate (Ke) and peak time of hepatic uptake-excretion curve (Peak Time). These parameters were determined in 51 patients with or without liver diseases. Kd, Ku and Ke significantly decreased and Peak Time also significantly prolonged in patients with chronic hepatitis, compensated and decompensated liver cirrhosis in serial order. In patients with acute hepatitis, marked decrease of Ke was observed. A good correlation was found between these parameters and other hepatic function tests such as ALP, ChE, Albumin, γ-globulin and ICG retention test. These results suggest that parameters obtained are sensitive index for evaluating the severity of liver damage.
    Therefore it is considered that the computer analysis of 99mTc-PMT dynamic curves is clinically very useful as hepatic function test.
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  • Ultrasonic measurement of portal and splenic venous flow and their velocities in normal subjects and patients with chronic liver disease
    Masayuki SAITO, Hidetaka TERABAYASHI, Katsunori WADA, Takatsune NAKAYA ...
    1984 Volume 25 Issue 10 Pages 1281-1287
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1281
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    Portal hemodynamics was investigated nonivasively in patients with cirrhosis and chronic hepatitis and in healthy adults using ultrasonic doppler system. Portal venous velocity was significantly reduced in patients with cirrhosis compared with normal subjects and patients with chronic hepatitis in supine position, whereas no significant difference was observed in portal venous flow among the three groups of controls, patients with chronic hepatitis and cirrhosis. Splenic venous flow, which was significantly correlated with spleen volume, was significantly increased in patients with cirrhosis compared with normal subjects and patients with chronic hepatitis. Of cirrhosis, splenic venous flow tended to be increased in patients with large varices or splenomegaly.
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  • Distribution of Ethanolamine Oleate after injecting into the esophageal varices studied by isotope; 99mTcO4-
    Minoru SUKIGARA
    1984 Volume 25 Issue 10 Pages 1288-1292
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1288
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    The purpose of this study is to clarify the distribution of sclerosant injected by endoscope.
    Sclerotherapy for esophageal varices was performed on 6 patients in 16 times of injection. The used sclerosant contained 5% ethanolamine oleate (EO) and 99mTcO4- solution at the ratio of volume 9:1 (EO-99mTc).
    At each injection session 5 to 20ml of this solution was injected into one varix. The distribution of injected material was observed by a scintillation camera.
    Systemic dissemination of the sclerosant through portal vein was demonstrated in five out of 16 procedures, in which the injections were correctly intravenous. Dissemination occured irrespective of the sclerosant volume injected. In these, most of the EO-99mTc was washed out within 5 minutes leaving a trace in the peri-esophageal veins. Effects of injection were, however, evident and the varices showed atrophic changes.
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  • Pathological alteration of hepatocellular carcinoma after transcatheter arterial embolization (TAE)
    Study of 10 autopsied cases
    Masato MAEDA, Wataru KOYAMA, Shigemi SAKAMOTO, Masaaki KANAYAMA, Yasus ...
    1984 Volume 25 Issue 10 Pages 1293-1300
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1293
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    Recently transcatheter arterial embolization (TAE) therapy has been done for unresectable hepatocellular carcinoma (HCC). The effectiveness of TAE therapy has been established in clinical aspects. However, there are few reports about histological studies of its effect. Ten autopsied cases of HCC after TAE therapy were examined histopathologically. Necrotic areas in the tumors were detected in all cases, but except in one case, tumor cells remained in the main tumor. TAE therapy had no effect on capsular and portal invasion of HCC. Recanalization of embolized arteries was also seen. In three autopsied livers barium was injected through coeliac arteries and tumor stain was found roentgenographically. Even twelve days after TAE therapy the recanalization of feeding arteries to the tumor was found. In one case, the embolized material, Gelfoam powder, remained in the tumor nodule, in the embolized arteries with thrombus formation, and in the necrotic areas. These results suggest that the reevaluation of TAE is necessary for the treatment of HCC.
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  • Clinical investigation on pituitary-gonadal axis in men with cirrhosis of the liver, with special reference to alcoholic cirrhosis of the liver
    Hiroiku KAWAXAM, Hisakatsu HASHIMOTO, Shoichi SUEMORI, Yasuyuki WATANA ...
    1984 Volume 25 Issue 10 Pages 1301-1311
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1301
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    The pituitary gonadal axis in men with alcoholic liver cirrhosis was compared to that of nonalcoholic liver cirrhosis in age-mached and similar grade of liver damege in men. Basal Testosterone level was reduced (p<0.05) in alcoholics compared to non-alcoholics and normal controls. Basal Estrone (p<0.01) and Estradiol (p<0.05) levels and basal Gonadotropins (LH, FSH) concentrations (p<0.05) were increased in alcoholics compared to non-alcoholics and controls.
    Increased rate of Testosterone responsed to hCG in alcoholics was reduced compared to nonalcoholics, but reserved function of Leydig cell was enough remained, Gonadotropins (LH·FSH) and Testosterone responses to LH-RH (100μg·IV) was studied, an exaggerated response of LH and FSH to LH-RH was observed in alcoholics relative to non-alcoholics and normal controls, but increased rate of LH and Testosterone responsed to LH-RH were reduced in alcoholics compared to both groups.
    Based upon these result, we speculate that alcoholic liver cirrhosis have either normal pituitary responses to LH-RH or at most, a very moderate degree of impairment of only"LH", but chronic alcohol administration appears to "down regulate" of LH receptor in the testis.
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  • A case of portal hypertension associated with nodular regenerative hyperplasia of the liver in systemic lupus erythematosus
    Shinsuke OHURA, Isamu WATANABE, Shunji FUTAGAWA, Yoshihiro YAGI, Mitsu ...
    1984 Volume 25 Issue 10 Pages 1312-1317
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1312
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    The patient, 38-year-old female, who had suffered from systemic lupus erythematosus since 1970 and received the administration of steroid treatment of thirteen years' duration. In 1983, she complained of hematemesis due to the rupture of esophageal varices and was admitted to our hospital. Liver function tests were normal but splenomegaly, anemia, purpura and dicrese of blood-platelets were observed. Selective celiac arteriography revealed intrahepatic aneurysm. The patient was subjectted to splenectomy, devascularization of the abdominal esophagus and the cardia, Increasement of blood-platelets and disappearance of the esophageal varices were recognized after the operation.
    Surgical liver biopsy was taken. Microscopically, nodules were characterised by small area of focal hyperplasia of liver cells, without fibrosis, distinctively demarcated by adjacent compressed, trophic liver cells. These are characteristic features of nodular regenerative hyperplasia of the liver.
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  • Solid liver hamartoma, bile ductal fibroadenomatous type Report of a case
    Hiroshi SONOBE, Hideaki ENZAN, Makoto KURAMITSU, Takuro OGATA, Kimio M ...
    1984 Volume 25 Issue 10 Pages 1318-1325
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1318
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    An unusual hepatic hamartoma developing in a 15 month-old female with abdominal distension of three month's duration was described. From the age of patient, high titer of serum α-fetoprotein and findings of computerized tomography and angiography of the lesion, hepatoblastoma was highly suspected, The oval, elastic hard and pedunculated lesion (900g, 14.5×13×7cm) arose in the anterior edge of left heaptic lobe, without adhesion. On cut-surface, the sharply demarcated, solid lesion was composed of irregular shaped islands of parenchyma and various sized nodules of fibrous stroma, intermingled with each other in a mozaic pattern. Histologically, the stroma included prominent bile ductal proliferation with periductal thickcollagenous bundles and angiomatous vascular proliferation with loose connective tissue, and it showed a similar feature to the intracanalicular type of mammary fibroadenoma. Islands of the differentiated parenchyma were pared off by the proliferating stroma. Immunohistologically, α-fetoprotein was demonstrated in the parenchymal cells of the lesion. It is reasonable to consider from these findings that the lesion is undoutedly a hamartoma and its essential change is fibroadenomatous proliferation of the bile duct. We propose here therfore, to call this solid hepatic lesion "bile ductal fibroadenomatous hamartoma".
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  • A case of hepatocellular carcinoma with intraorbital metastasis
    Takashi MATSUURA, Kishio ONO, Masaaki ANDO, Shigeru SAKAMOTO, Junji NI ...
    1984 Volume 25 Issue 10 Pages 1326-1331
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1326
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    A 49-year-old male was admitted to our hospital because of exophthalmus and liver dysfunction. He had been pointed out liver dysfunction for the past 10 years. He had a left temporal headache 2 months prior to admission. Left exophthalmus with ophthalmalgia and left hypochondralgia appeared 2 weeks before admission. On examination, jaundice, left exophthalmus and hepatosplenomegaly were observed. He was diagnosed as hepatocellular carcinoma with liver cirrhosis by blood chemistry, ultrasonic tomography, liver scintigram and aspiration cytology. Brain CT scan showed left intra-orbital and right sphenoid bone metastasis. Autopsy revealed diffuse hepatocellular carcinoma with multiple hone meatstases and left intra-orbital metastasis.
    We described a case of hepatocellular carcinoma with intra-orbital metastasis since the condition was rare.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 25 Issue 10 Pages 1332
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1332
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 25 Issue 10 Pages 1333
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1333
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 25 Issue 10 Pages 1334
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1334
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1984 Volume 25 Issue 10 Pages 1335
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1335
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 25 Issue 10 Pages 1336
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1336
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 25 Issue 10 Pages 1337
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1337
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1984 Volume 25 Issue 10 Pages 1338
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1338
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1984 Volume 25 Issue 10 Pages 1339
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1339
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 25 Issue 10 Pages 1340
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1340
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1984 Volume 25 Issue 10 Pages 1341
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1341
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1984 Volume 25 Issue 10 Pages 1342-1375
    Published: October 25, 1984
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.25.1342
    JOURNAL FREE ACCESS
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