-
Hiroiku KAWAKAMI, Hiromu TAKENO, Seiki YAMASHITA, Masaya KIKKAWA, Hiro ...
1984 Volume 25 Issue 12 Pages
1513-1521
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
Anti-HBe survey in 2326 HBsAg positive blood donors revealed a HBeAb increase of 20.1% in females of 20th and 30th generations, but 9.7% in males almost invariably at ages from 25 to 36. In HBeAg positive donors, the GPT level was abnormal in 234 (46.8%) of 500 males andmore mildly (p<0.001) in 61 (29.0%) of 210 females. This indicated only a mild hepatic dysfunction in females at lower ages than males and suggested the possibility of a higher rate of seroconversion from HBeAg to HBeAb. The yearly seroconversion rate amounted to 9.1% in ASC (6.5% hepatic dysfunction patients and 1.3% normals). Histologically, seroconversion occurred in none of 17 NSRH or 20 CPH, but 5 (9.8%) of 51 chronic active liver diseases type B. Elevation of S-GPT above 200U during seroconversion from HBeAg to HBeAb was noted in 7 of seroconverted 11 cases (63.7%), which were mostly CAH (2A).
View full abstract
-
Naoya MURASHIMA, Hiromitsu KUMADA, Kenji IKEDA, Akira YOSHIBA, Kyoko N ...
1984 Volume 25 Issue 12 Pages
1522-1526
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
Serial studies on e antigen-positive chromic hepatitis type B have revealed reappearance of e antigen after serocovension from e antigen to e antibody. Ninety four patients who were e antigen-positive initially, were followed for 54 months. Thirty nine of 94 patients (41.5%) have had e antigen continuously, 28 patients (29.8%) have shown seroconversion from e antigen to e antibody. Reappearance of e antigen after seroconvension (reversed seroconvension) were observed in 5 of 94 patients (5.3%). Twenty of 94 patients (21.3%) lost e antigen, reappeared without appearance of e antibody.
These 25 cases who demonstrated reappearance after loss of e antigen contained only one female, and male was significantly dominant (p<0.05).
Reversed seroconversion occurred in cases of chronic aggressive hepatitis IIb and liver cirrhosis all but one chronic aggressive hepatitis IIa.
View full abstract
-
Hidenori KANAZAWA, Norihiko TADA, Toshihiko NAGAI, Hajime KURODA, Kenj ...
1984 Volume 25 Issue 12 Pages
1527-1533
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
The effects on portal pressure and hepatic blood flow of intravenous and oral administration of propranolol were studied in 10 patients with cirrhosis. The wedged and free hepatic venous pressure were measured by hepatic vein catheterization. Portal pressure was expressed as the gradient between the wedged and free hepatic venous pressure (Hepatic venous pressure gradient: HVPG). Estimated hepatic blood flow (EHBF) was assessed by the indocyanine green continous infusion method.
Both intravenous and oral administration of proranolol significantly reduced HVPG and EHBF. There was significant correlation between the decrease in HVPG and decrease in EHBF after propranolol. In 4 patients whose basal EHBF were below 0.5l/min/mm
22, the decrease in EHBF after propranolol was small.
It is suggested that, in patients with cirrhosis, (a) propranolol reduces the hepatic blood flow and lowers the portal pressure, and (b) these effects may be smaller in patients with a marked decrease of basal hepatic blood flow.
View full abstract
-
Hidemasa OKUMURA, Tatsuya SEKIYAMA, Yasumi KATSUTA, Takumi ARAMAKI, Ka ...
1984 Volume 25 Issue 12 Pages
1534-1540
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
The effects of propranolol on portal venous pressure were evaluated in 19 patients with hepatic cirrhosis and one with chronic aggressive hepatitis. After intravenous infusion of 5mg of propranolol for 10 minutes, wedged and free hepatic venous presure (WHVP, FHVP), estimated hepatic blood flow (EHBF), cardiac output and total systemic vascular resistance (TSR) were measured serially. Portal venous pressure (WHVP-FHVP) decreased significantly by 23% at 20 minutes after the start of infusion and the effect persisted for 50 minutes. The heart rate, cardiac index and EHBF reduced significantly by 13%, 24% and 13%, respectively, whereas TSR increased by 34%. After the infusion of vasopressin (0.2U/ml) for comparative purposes, portal venous pressure reduced by about 30% at 10 minutes, the difference of reduction in portal venous pressure between both agents being insignificant. Mean plasma propranolol concentration, measured by high liquid chromatography in 4 out of 20 patients, was 20.3±5.3ng/ml at 20 minutes after the start of infusion.
These results reveal that propranolol may have efficacy for the reduction of portal venous pressure and that the effect may be maintained at the level of above 20ng/ml of plasma propranolol concentration.
View full abstract
-
Shuichi SEKI, Hisanori KITAGAWA, Takayasu MATSUI, Shinya NAKAJIMA, Tet ...
1984 Volume 25 Issue 12 Pages
1541-1545
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
We extended morphological study on 84 rahbits through the immunization with antigen prepared from fresh bovine gallbladder mucouse membrane in order to clarify the initial lesions and its incidence.
In 47 out of 84 rabbits (56%), preicholangitis with and without granuloma was founded out. In addition, chronic non-suppurative destructive chonlangitis was recognized in six rabbits. This fact indicated that experimental primary biliary cirrhosis model was induced through our experimental methods.
And there's no corellations between the frequency of immunization and the incidence of chronic non-suppurative destructive cholangitis and pericholangitis, therefore it was thought that the individual differential sensitivity existed in the provocation and the development of the disease.
View full abstract
-
Takayuki ARAI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, Yoshihiro IKEMOTO, ...
1984 Volume 25 Issue 12 Pages
1546-1551
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
When human peripheral blood mononuclear cells were stimulated with phytohemagglutinin (PHA), pokeweed mitogen (PWM) or concanavalin A (Con A), lymohocyte transformation was induced. This mitogen-induced lymphocyte transformation was significantly inhibited by adding the culture supernatant of Kupffer cells from rats.
However, this effect of Kupffer cells on the lymphocyte transformation was partially inhibited by indomethacin.
These results suggested that suppression of lymphocyte transformation by Kupffer cells was attributable, at least in part, to the effect of prostaglandins.
View full abstract
-
Yasuhiro MIZOGUCHI, Hiroko KATOH, Hiroko TSUTSUI, Keiji MIYAJIMA, Taka ...
1984 Volume 25 Issue 12 Pages
1552-1556
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
A significant liver cell damage was induced when the isolated liver cells coated with the specific antibody against the liver cell membrane were cultured with peripheral blood mononuclear cells and their culture fluid was added to the isolated liver cells. These were demonstrated by measuring the decrease in protein synthesis of liver cells. These liver cell injuries by antibody-dependent cell-mediated cytotoxicity (ADCC) were significantly potentiated by adding the culture supernatant of LPS-activated Kupffer cells to the effector cells. Since interleukin-1 activity was detected in the culture supernatant of LPS-activated Kupffer cells, it is likely that augmentation of ADCC by activated Kupffer cells is attributable to interleukin-1 at least partially.
These results suggest a possibility that Kupffer cells may modulate the ADCC reaction.
View full abstract
-
Yoshikazu SAKAGUCHI
1984 Volume 25 Issue 12 Pages
1557-1566
Published: December 25, 1984
Released on J-STAGE: July 30, 2022
JOURNAL
FREE ACCESS
In order to clarify the relationship between blood viscosity and hepatic vascular resistance, the isolated normal and CCl4-induced rat livers were perfused with Krebs-Ringer bicarbonate buffer solution suspended with bovine erythrocytes (hematocrit of 0% to 65%). Portal vein pressures in vivo of the normal rat (128.0±2.4mmH
2O) and of the cirrhotic rat (180.5 ±10.1mmH
2O) approximated to the lowest perfusion pressures providing the minimum hepatic vascular resistance at hematocrit of 40% (economical perfusion pressure). In the cirrhotic liver the economical perfusion pressure elevated markedly with increasing hematocrit, especially over hematocrit of 40%, than in the normal liver. This is because that in the cirrhotic liver an increase in number of the narrow sinusoids less than 10μm in diameter led to elevation of the hepatic vascular resistance and the high viscosity of the perfusate. These experimental findings suggest that an increase in hematocrit may cause a prominent elevation of portal vein pressure in the patient with cirrhosis.
View full abstract
-
Munehiko TANNO, Hideo YAMADA, Sumi NAGASE, Junichi NAGASHIMA, [in Japa ...
1984 Volume 25 Issue 12 Pages
1567-1572
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
To investigate of the effect of serum albumin on serum clearance of organic anion, cumulative excretion rates of BSP into bile were measured in SD rat and Analbuminemic Rat (NAR).
In SD rat, 70.7±4.9% of administered dose was excreted within 15min after intravenous injection of 0.5mg BSP/100g body weight, whereas these in NAR decreased to 53.7±1.4%, respectively. Similar tendency was also observed in both group administered of 0.25mg BSP/100g body weight.
However, there is no apparent effect on cumulative excretion rate of BSP in NAR, when serum albumin and BSP administered simultaneously to NAR. These results suggest that serum albumin and assumptive albumin receptors on the liver plasma membranes do not probably have a important role for the uptake of organic anions into hepatocyte.
View full abstract
-
Teruo NAKAMURA, Isao MAKINO, Ken-ich IMAMURA, Tadashi MIYAZAWA, Koji M ...
1984 Volume 25 Issue 12 Pages
1573-1578
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
1. In this study relation of skin bile acid content or serum bile acid level to the pruritus in patients with hepatobiliary diseases were studied.
2. Skin surface bile acids of 19 patients (10 non-pruritics, 7mild pruritics and 2 severe pruritics) were fractionated according to their mode of conjugation by using Sephadex LH-20 and PHP-LH-20, and analyzed by gas-liquid chromatography, while total bile acid concentration in fasting serum was measured by enzymatic method.
3. There were no differences in the bile acid concentration and composition of skin surface or serum bile acid level between the groups with pruritus and that without pruritus.
4. However, the bile acid content of skin surface increased nearly to that of serum bile acid and the correlation coefficiency was 0.606 (p<0.05).
5. The increased bile acid on the skin surface in patients with hepatobiliary diseases was mainly composed of free chenodeoxycholic acid.
6. These findings suggest that bile acids do not play a causative role in the pruritus of the patients with cholestatic liver diseases.
View full abstract
-
Takahiro EZAKI, Takashi KANEMATSU, Takashi MATSUMATA, Takashi SONODA, ...
1984 Volume 25 Issue 12 Pages
1579-1582
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
We successfully treated a 57-year-old male, cirrhotic patient who developed hepatic failure after hepatic resection for carcinoma of the liver, with hyperbaric oxygenation therapy. Hepatic encephalopathy was evident with clinical finding, serum chemistry and electroencephalogram on about 30 day after the operation. First, he had plasma exchange as a treatment of hepatic failure, which was unsuccessful. Hyperbaric oxygenation therapy, performed 20 times in the period of 47th-70th postoperative day, made complete improvement of encephalopathic status.
This result is suggestive that hyperbaric oxygenation therapy can be used for liver support in patients who have developed hepatic insufficiency.
View full abstract
-
Hiroyuki ABURATANI, Takashi ISHIKAWA, Tatsuhiko KODAMA, Eiichi SAITOH, ...
1984 Volume 25 Issue 12 Pages
1583-1588
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
Acute fatty liver of pregnancy was found in a 30 year-old primiparous female. After delivery of a male infant on 9th month of pregnancy, symptoms of acute liver failure including semi-coma, jaundice and ascites appeared. Needle liver biopsy specimen showed cholestasis, microvesicular fat deposition in hepatocytes and minor cell necrosis. Electron microscopy showed the swollen mitochondria and damaged cristae. Small-vesicle lipid infiltration in cytosol was seen. Serum cholesterol and triglyceride was 126mg/dl and 274mg/dl, respectively. Quantitation of serum apolipoprotein concentrations showed normal apo B, increased apo E, and decreased apo AI, AII levels. Analysis of plasma lipoproteins revealed the decrease of HDL2 and HDL3 levels. HDL2 fraction was rich in apo E and consisted of large-sized particles. In addition, triglyceride content of both density<1.006g/ml fraction and 1.006<d<1.063g/ml fraction was increased. Apo B48 level in d<1.006 fraction also increased. LDL fraction consisted of large-, intermediate- and normalsized particles. These results suggest the defective removal of remnant lipoproteins and decreased synthesis of lipoproteins by the liver in this patient.
View full abstract
-
treatment of hyperbilirubinemia by selective plasma exchange
Takuro NAKAYAMA, Tatsushi KISHINO, Takatoshi NOGUCHI, Hisashi YASUOKA
1984 Volume 25 Issue 12 Pages
1589-1597
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
We have developed a new plasma exchange therapy by means of the membrane type plasma component separator Evaflux 2A, by which free and albumin-bound bilirubin in the blood can be selectively removed. We conducted this therapy on a patient with refractory intrahepatic cholestatic hepatitis supposed to be induced by Tiopronin and accompanied by hyperbilirubinemia which manifested six months ago, and we obtained good therapeutic results.
The removal rate of bilirubin by this procedure was about 21 per cent, and 70 per cent of the bilirubin removed was of the direct type. No change was observed in the total amount of protein, protein fractions, electrolytes in the blood before and after this therapy. Liquid chromatograpy showed that 86 per cent of the protein removed had smaller molecular weight than albumin.
The conventional plasma exchange therapies often cause serum hepatitis or abnormalities in electrolytes due to fresh frozen plasma (FFP), while absorption therapy using activated charcoal or IONEX can remove free bilirubin but not the other bilirubins. To solve these problems, we used 0.4 per cent albumin-added electrolyte solution instead of FFP in this therapy. As a result, this new therapy has permitted a relatively selective removal of bilirubin in the blood without causing complications due to FFP.
View full abstract
-
Osamu NISHIDA, Fuminori MORIYASU, Takefumi NAKAMURA, Nobuyuki BAN, Ken ...
1984 Volume 25 Issue 12 Pages
1598-1604
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
A 63-years old woman was admitted to our hospital because of severe jaundice. Five years ago, an interposition mesocaval shunt operation was performed because of bleeding from esophageal varices. US and CT detected a large hepatic tumor. Hepatic catheterization was performed. The blood flow volume was measured by an ultrasonic duplex system, and blood pressure was measured simultaneously in the portal venous system. Pressure gradient of the shunt was 6 mmHg and its blood flow was about 3, 000 ml/min. It was proved that the vascular resistance was very low. It was found that the portal blood flow had been reversed. But we suspected sufficient blood flow through the hepatic sinusoid. The high sinusoidal pressure was maintained by both the high portal vein and high inferior vena cava pressures, which were caused by an obstruction of the inferior vena cava from the growth of the hepatic tumor.
View full abstract
-
Masatoshi KUDO, Masahiro HIRASA, Hiroshi TAKAKUWA, Yasushi IBUKI, Kats ...
1984 Volume 25 Issue 12 Pages
1605-1611
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
A 71-year-old male was admitted with complaints of subcutaneous purpura and right hypochondrial pain. He had an episode of being injected with Thorotrast for his war wound in 1939. Intraperitoneal bleeding and disseminated intravascular coagulopathy (DIC) were seen on admission.
Abdominal ultrasonography (US), computed tomography (CT), liver scintigraphy and right heaptic arteriography revealed two tumors in the liver, one is in the right lobe and the other is inthe medial segment of the left lobe. The finding of US shows a mesh-like or honeycomb-like pattern and the angiogram shows a cotton wool like appearance in the capillary phase, which is consistent with cavernous hemangioma.
A right hepatectomy was performed and the histological findings of the resected tumor found it to be hemangiosarcoma of the liver, which is very rare.
Our reported case is considered to be the first case in Japan, in which Kasabach-Merritt syndrome occurred based on hemangiosarcoma of the liver.
View full abstract
-
Masakatsu UCHIHARA, Masato MAEDA, Wataru KOYAMA, Shigemi SAKAMOTO, Mas ...
1984 Volume 25 Issue 12 Pages
1612-1615
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
A 35-year-old man was administered metronidazole because his wife suffered from trichomonas vaginalis. About two weeks after administration of the drug, he was admitted to the hospital with fever and abdominal distension. On admission, laboratory data showed leukocytosis with eosinophilia and elevation of transaminase levels. The lymphocyte transformation test showed positive when metronidazole was added to the culture medium of the lymphocyte. The liver biopsy specimen showed zonal necrosis of centrilobule and mononuclear cells' infiltration. These observations indicate a metronidazole-indgced liver injury. To the best of our knowledge, this is the first case reported with metronidazole-induced liver injury. Metronidazole has been widely used for the treatment of trichomonas vaginalis, so physcians should be aware of liver injury as a possible complication of this drug's use.
View full abstract
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1616
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1984 Volume 25 Issue 12 Pages
1617
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1618
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1984 Volume 25 Issue 12 Pages
1619
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1620
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1621
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1622
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1623
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese]
1984 Volume 25 Issue 12 Pages
1624
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1984 Volume 25 Issue 12 Pages
1625
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1984 Volume 25 Issue 12 Pages
1626
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS
-
1984 Volume 25 Issue 12 Pages
1627-1664
Published: December 25, 1984
Released on J-STAGE: July 09, 2009
JOURNAL
FREE ACCESS