Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 29, Issue 9
Displaying 1-23 of 23 articles from this issue
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  • Detection of Pre-S1, S2 peptides in plasma derived vaccine
    Yoshimi ITO, Masao OMATA, Osamu YOKOSUKA, Naoko HAYASHI, Masao OHTO
    1988 Volume 29 Issue 9 Pages 1165-1170
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1165
    JOURNAL FREE ACCESS
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    We studied Pre-S1/S2 peptides in different hepatitis B vaccines and their productivity of antibodies against Pre-S1/S2 peptides by immunoblotting method.
    We found relatively large amount of Pre-S1/S2 peptides in one plasma derived HB vaccine, not in another two plasma derived HB vaccines and in one HB vaccine from recombinant yeast.
    Antibodies for Pre-S1/S2 were found in 23.6% of individuals who were vaccined with Pre-S1/S2 peptides positive vaccine, and positive for anti-HBs antibody.
    These data suggested that some plasma derived vaccines had the productivity of antibodies for Pre-S1/S2.
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  • Extensive hepatic cell necrosis produced by a lymphokine and its partial characterization
    Toshiyuki KOMADA, Tsuneko NAKAJIMA, Noriyuki KITAMI
    1988 Volume 29 Issue 9 Pages 1171-1180
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1171
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    Hepatic cell necrosis in rabbits was experimentally produced by administration of lymphokine either intraperitoneally or into the hepatic portal vein which appeared in culture supernatants of stimulated lymphocytes obtained from rabbits immunized with rat liver homogenates. The severity of the necrosis was roughly proportional to the dose of the lymphokine and submassive necrosis was observed in the most severely affected animals. The lymphokine showed dose-dependent cytotoxicities against isolated rat hepatocytes and Chang liver cells in vitro, but not against murine L929 cells. The molecular weights were between 40, 000 and 90, 000 according to Sephadex G-100 gel filtration. The cytotoxic activity was disappeared following heating at 56°Cfor 30 minutes or by trypsin digestion, but was not affected by neuraminidase treatment. These results suggested that a hepatocytotoxic lymphokine played an important role in the progression of hepatic necrosis and that this lymphokine was different from lymphotoxin.
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  • Determination of middle molecular substances in sera and cerebro-spinal fluids of patients with acute hepatic failure
    with special reference to the development of brain edema
    Jun-ichi SUGIHARA, Koshiro SAITO, Eiichi TOMITA, Yasutoshi MUTO
    1988 Volume 29 Issue 9 Pages 1181-1193
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1181
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    A study was conducted to investigate the possible role of middle molecular substances (MMS) in the pathogenesis of brain edema (BE) in patients with acute hepatic failure (HF).
    Sera obtained from patients with AHF were found to inhibit in vitro the activity of partially purified rat brain microsomal Na+, K+-ATPase, and a majority of the inhibitory effects was identified in the middle molecular weight range (approximately between 2, 000 and 4, 600 daltons) on gelchromatography. Moreover, HPLC analysis of sera and cerebro-spinal fluids (CSF) of the patients with AHF revealed marked increases of several peak areas in the middle molecular weight range, in particular, below 4, 000. These levels increased in parallel with developing grades of hepatic coma and were found to be significantly higher in the patients with BE than in those without BE. Since the concentrations of MMS showed significant negative correlations with prothrombin time and hepaplastin test, and positive correlations with plasma levels of methionine and of aromatic amino acids, it is conceivable that MMS levels change in accordance with the degree of hepatic failure.
    These results suggest that MMS, increased in both sera and CSF in AHF patients, is closely related to hepatic encephalopathy and that some portions of MMS are virtually involved in the development of BE, by interfering the function of sodium pump of brain membrane.
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  • Repair of CCl4 induced acute liver damage with epidermal growth factor and its biochemical analysis
    Kazutoshi SANUKI
    1988 Volume 29 Issue 9 Pages 1194-1201
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1194
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    This study was performed to evaluate effect of EGF on stimulation of DNA synthesis in acute liver injury induced by CCl4 in rat, and in association with this, changes of EGF receptor and EGF concentrations in liver tissue were examined. The following results were obtained; a significant increase of DNA synthesis, determined by incorporation of bromodeoxyuridine were observed in the rats administered EGF, and in addition administration of EGF-glucagon-insulin cocktails stimulated DNA synthesis in the liver much more. Regarding EGF receptor, in early time of liver injury, number of EGF receptor was significantly decreased and improved immediately in accordance with hepatic repair. EGF level in tissue decreased similar to EGF receptor, but its improvement was delayed. These results suggest that EGF is extremely important hepatotorophic factor involved in repair system after liver injury.
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  • Mechanism of alcoholic liver damage
    Harmful effect of high concentration of ethanol
    Yoshiyuki TAKEI, Nobuhiro SATO, Sunao KAWANO, Takakatsu MATSUMURA, Har ...
    1988 Volume 29 Issue 9 Pages 1202-1207
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1202
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    The effect of a high concentration of ethanol on hepatic functions was examined in perfused rat livers. Ethanol was infused into livers in a stepwise manner from 5mM to 500mM.
    1. The addition of 5mM and 50mM solution of ethanol produced a mild increase in hepatic oxygen consumption with a minimal change of bile flow, hepatic contents of adenine nucleotides and hepatic energy charge.
    2. When ethanol from 100mM to 200mM and 500mM was infused, hepatic oxygen uptake as well as bile flow decreased dose-dependently, associated with the change of mitochondrial respiratory cytochromes to reduced form. Hepatic contents of ATP and energy charge also diminished and the diminishment was significantly correlated with the bile flow.
    These findings suggested that a high concentration of ethanol over 100mM or its metabolites has an inhibitory effect on mitochondrial oxidative phosphorylation, resulting in hepatic functional damage.
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  • Prognosis of liver cirrhosis considered by the Cox's proportional hazards regression model
    Etsuko HASHIMOTO, Hikaru NAGAHARA, Hiroaki OKUDA, Toju HISAMITSU, Hiro ...
    1988 Volume 29 Issue 9 Pages 1208-1214
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1208
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    The aim of this study was to assess the prognostic values of variables in 368 patients with confirmed cirrhosis (282 males and 86 females) who were admitted during the period of 1973 to 1982 and followed up until 1985, and to determine which variables reflected the causes of death. To assess the combined effects of several prognostic variables, the Cox's proportional hazards regression model was used. The five year survival rate was 63%. One hundred and forty nine patients had died, 57 from hepatocellular carcinoma (HCC), 41 from gastrointestinal bleeding and 31 from hepatic failure. With the Cox's model, the following four variables had a significant prognostic effect: Globulin, Ch-E, male sex and hepaplastin test. According to the causes of death, age, high AFP level, positive HBsAg and ICG were significant factors in HCC, ICG and GPT in gastrointestinal bleeding, and A/G ratio and low AFP level in hepatic failure. A final model determining the probability of a patient dying from HCC and other causes within 5 years was established.
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  • A case-control study of liver cancer among Koreans in Japan
    Su Jun PYONG, Hi Ung LEE, Takashi UBUKATA, Tomohiko HIYAMA, Akira OSHI ...
    1988 Volume 29 Issue 9 Pages 1215-1221
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1215
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    A case-control study was undertaken to evaluate the role of hepatitis B virus (HBV), smoking and alcohol in the etiology of liver cancer among Koreans in Japan. The case group was 116 newly diagnosed primary liver cancer cases and two controls for every case were randomly selected from admitted patients by matching to age, sex, year of admission and medical care insurance.
    The relative risk (RR) of liver cancer among HBs-Ag positives was 19.58 and the risk after adjustment for drinking habits was 11.35 for males and 15.26 for females. Smoking was not related with liver cancer risk but daily drinking increased the risk of this cancer (RR of 1.99). For males, a significant dose-responce relationship was seen between drinking and liver cancer risk. Population attributable risk was estimated as 56.5% for drinking, 23.1% for HBs-Ag positive and 13.3% for smoking among males, and 41.4% for HBs-Ag positive and 7.0% for drinking among females. In addition, liver cancer risk among HBs-positives was highly increased by heavy drinking.
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  • Aggressive surgery for patients with hepatocellular carcinoma and hepatoblastoma with tumor thrombi in the portal trunk, hepatic vein
    inferior vena cava and right atrium
    Toshiharu TSUZUK, Shuhei IIDA, Manabu KASAJIMA, Masakazu UEDA, Iwao OZ ...
    1988 Volume 29 Issue 9 Pages 1222-1232
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1222
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    Hepatocellular carcinoma with tumor thrombi in the portal trunk, hepatic vein and inferior vena cava has been deemed unresectable. However, it is amenable neither to arterial embolization nor to chemotherapy and the patients usually die within a few months after diagnosis. The only way to treat these patients is to resort to aggressive surgery consisting of hepatic resection and removal of tumor thrombi.
    We have performed hepatic resection or other procedures along with removal of tumor thrombi on seven patients with hepatocellular carcinoma and one patient with hepatoblastoma.
    We have disclosed that the procedure is technically feasible and have carried out various trials for long-term survival with some success in a patient.
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  • Localization of Cu, Zn-Superoxide dismutase (SOD) in the liver tissue of patients with liver diseases by immunoperoxidase technique
    Light and electron microscopic studies
    Takafumi SAITOH, Haruhide SHINZAWA, Hitoshi TOGASHI, Hiroto WAKABAYASH ...
    1988 Volume 29 Issue 9 Pages 1233-1240
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1233
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    The localization of Cu, Zn-SOD in the liver tissue was studied by using an immunoperoxidase technique. Cu, Zn-SOD was localized in the nucleus and cytoplasm of hepatocytes by light microscope. The intensity of distribution of Cu, Zn-SOD stain was marked in such liver cells as those close to fibrosis, or either those with fatty degeneration or with ballooning degeneration. So Cu, Zn-SOD was speculated to be produced against the toxic effect of superoxide radical causing ischemia or degeneration.
    By immunoelectron microscope, Cu, Zn-SOD was observed at endoplasmic reticulum, perinuclear space, cytoplasmic vesicles and Golgi apparatus in the hepatocytes. Moreover, Cu, Zn-SOD was also seen around fat depositted area within hepatocytes, while in liver cirrhosis Cu, Zn-SOD was also on cell membrane. Thus, our immunoelectron microscopic study might suggest that Cu, Zn-SOD was producted and secreted in the hepatocytes representing cytoprotective mechanism.
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  • Effects of malotilate on the substrate-metabolizing activities in liver microsomes and the elimination half-lives of drugs
    Hiroyasu OKUNO
    1988 Volume 29 Issue 9 Pages 1241-1252
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1241
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    The effects of malotilate on drug metabolizing activity in rats were examined. The content of cytochrome b5(b5)and the activity of NADPH-cytochrome c reductase in the microsomal fraction were noticeably increased, whereas the content of cytochrome P-450(P-450)was slightly decreased by the malotilate treatment. 7-ethoxycoumarin O-deethylation was markedly and aminopyrine N-demethylation was moderately enhanced; in contrast, aniline hydroxylation was significantly and benzo(a)-pyrene hydroxylation was slightly reduced.
    Malotilate induced the O-dealkylation activities of coumarin derivatives(7-methoxy-, 7-ethoxyand 7-propoxycoumarin)in a different pattern from that induced by either phenobarbital or 3-methylcholanthrene.
    The elimination half-life of theophylline was noticeably increased, whereas that of disopyramide was significantly decreased by the malotilate treatment; on the other hand, the half-lives of lidocaine and gentamicin were not significantly affected.
    Such different effects of malotilate among the substrate-metabolizing activities and the elimination half-lives of drugs may be due partly to the increase in the content of b5; malotilate may have affected the population of P-450 subtypes as well.
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  • Two cases of autoimmune hepatitis died of hepatic failure with fulminant clinical course
    Yoshiyuki NAKANO, Kiyoshi FURUTA, Kimiaki TSUCHIYA, Yukio GIBO, Takesh ...
    1988 Volume 29 Issue 9 Pages 1253-1258
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1253
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    Two cases of autoimmune hepatitis with fulminant clinical course are reported.
    Case 1 was a 42-year-old woman who complained of jaundice. Laboratory data revealed severe liver dysfunction and hypergammaglobulinemia (4.4g/dl). Anti-nuclear antibody (ANA), anti-DNA antibody and anti-smooth muscle antibody (ASMA) in serum were all positive. LE cell phenomenon was also positive. Despite of the treatment with corticosteroid, her condition rapidly went into downhill course and she died of hepatic failure. Case 2 was a 46-year-old woman who complained of jaundice. Laboratory data showed severe liver dysfunction and hypergammaglobulinemia (3.2g/dl). ANA and ASMA were positive. She was treated with corticosteroid with no response.
    Postmortem histological studies of the livers in both cases revealed massive hepatic necrosis. Hepatitis virus infection, alcohol and drug were not incriminated in these cases. Though the etiology of the evolution of fulminant course in these two cases with autoimmune hepatitis could not be identified, some immunological mechanisms may be concerned.
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  • A case of chronic active hepatitis showing hepatic encephalopathy with mesenteric varices and hypokalemia due to Bartter's syndrome
    Mitsuhiro TERADA, Kazuo NOTSUMATA, Hideyuki RYORIN, Shou AOYAMA, Yoshi ...
    1988 Volume 29 Issue 9 Pages 1259-1264
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1259
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    We reported a rare case of shunt encephalopathy with mesenteric varices and hypokalemia due to Bartter's syndrome. In March 1987, a 58-year-old female was admitted to our hospital due to abnormal behavior and tremor. On admission, marked elevation of serum ammonia and hypokalemia were found, and EEG suggested hepatic encephalopathy. Peritoneoscopic findings showed motley liver. Histological findings showed chronic active hepatitis with lobular disarray. MR-CT scan and abdominal angiography revealed that there was a shunt via mesenteric varices between mesenteric vein and inferior vena cava. On the other hand, it was suggested that this case was associated with Bartter's syndrome because a defect of chloride reabsorption in the loop of Henle was found. It is of interest to speculate that hypokalemia due to Bartter's syndrome made hepatic encephalopathy more pronounsed.
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  • A case of true hepatic cyst with malignant change
    Shugo KASHIMA, Yoshihiro ASANUMA, Makoto NIWA, Kenji KOYAMA
    1988 Volume 29 Issue 9 Pages 1265-1268
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1265
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    A 62-year-old female, suffering from epigastric discomfort, was seen at our hospital. Giant true cyst was found out at the left hepatic lobe by CT and celiotomy was performed.
    Intraoperative histological examination of the frozen section of the cyst wall indicated the malignancy of the cyst. Left hepatic lobectomy was carried out and a main tumor (4×3×3cm) and many rice-sized small nodules were found out at the inside of the cyst. They were histologically diagnosed as well differentiated adenocarcinoma. Other part of the inside surface of the cyst was lined with a layer of cylinderical epithelium and some parts of epithelium were diagnosed as a typical one.
    Since there were normal epithelium between the main tumor and small nodules, multicentric canceration was indicated.
    The patient died of peritonitis carcinomatosa 10 months after the operation.
    Of the operation for true hepatic cyst, the canceration must be always suspected. At first, content should be aspirated without dispersion, then frozen section of the cyst wall must be examined histologically. When canceration is diagnosed or highly suspected, hepatic lobectomy must be performed.
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  • An autopsied case of hepatocellular carcinoma associated with a skin invasion via ligamentum teres hepatis
    Yoshiharu MOTOO, Kenzo IKEDA, Naoki YAMASHITA, Akihiko FURUSAWA, Nobuy ...
    1988 Volume 29 Issue 9 Pages 1269-1273
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1269
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    A 59-year-old man was admitted to our hospital due to abdominal fullness and abdominal wall tumor in September 1985. Laboratory data showed liver dysfunction with a high level (13100ng/ml) of alpha-fetoprotein. Various imaging studies revealed a main tumor in the medial segment of the left hepatic lobe with multiple daughter nodules and a tumor thrombus in the left portal vein. In spite of the chemotherapy, the patient died due to hepatic failure in November 1985. The autopsy revealed hepatocellular carcinoma of Edmondson grade III in a cirrhotic liver. The skin tumor of 2cm in size located in the umbilical area was a direct invasion of the hepatoma via the ligamentum teres hepatis.
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  • A study of the increasing age of occurrence of autoimmune hepatitis
    Mikio NISHIOKA, Hiroyuki KAGAWA, Sukeo YAMAMOTO, Tetsuo KUROKI
    1988 Volume 29 Issue 9 Pages 1274-1275
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1274
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  • Comparison of immunity between the patients with thorotrastosis and healthy controls
    Kendo KIYOSAWA, Kohji YABU, Haruhiko IMAI, Seiichi FURUTA, Hiroshi YAM ...
    1988 Volume 29 Issue 9 Pages 1276-1277
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1276
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  • Scanning electron microscopic observation of proliferated bile ductules using the chemical digestion method
    Ryuzou TOKIYA, Toshinari KOBAYASHI, Seiji TOKUMITSU, Yasuhiro SUEMUNE, ...
    1988 Volume 29 Issue 9 Pages 1278-1279
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1278
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  • Effect of interferon treatment of hepatitis B virus infection on intrahepatic HBeAg
    Gotaro YAMADA, Kouich TAKAGUCHI, Kazuhiro MATSUEDA, Hiroaki OKUSHIN, T ...
    1988 Volume 29 Issue 9 Pages 1280-1281
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1280
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  • Heterogenous cirrhotic nodules within the same livers patterned from HBV DNA
    Hideaki YASUI, Okio HINO, Keiko OHTAKE, Hiromu AOYAMA, Mitsuru HARA, J ...
    1988 Volume 29 Issue 9 Pages 1282-1283
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1282
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1988 Volume 29 Issue 9 Pages 1284
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1284
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1988 Volume 29 Issue 9 Pages 1285
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1285
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1988 Volume 29 Issue 9 Pages 1286
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1286
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  • [title in Japanese]
    1988 Volume 29 Issue 9 Pages 1287-1317
    Published: September 25, 1988
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.29.1287
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