Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
Search
Advanced search
OR
Browse
Search
Volume 30, Issue 11
Displaying 1-17 of 17 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • Changes of hepatic HBV DNA before and after interferon treatment in patients with chronic hepatitis type B
    Comparison between Southern blot hybridization and polymerase chain reaction
    Masayuki MATSUMOTO, Tadao OKUNO, Michiko SHINDO, Ken ARAI, Makoto TAKE ...
    1989 Volume 30 Issue 11 Pages 1553-1557
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1553
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We studied hepatitis B virus (HBV) DNA in the liver of 17 patients with chronic active hepatitis B who were treated with interferon (IFN). After IFN treatment 5 patients lost hepatic HBV DNA and one patient remained only supercoiled form by Southern blot hybridization method. In these 6 patients, hepatic HBV DAN was also studied by polymerase chain reaction (PCR) method. The target sequence, 432 bp in S region of HBV genome, was amplified 25 times by PCR method. Amplified target sequence was detected by ethidium bromide staining and Southern blot hybridization with 32P-labeled probe. In all patients hepatic HBV DNA was detected both before and after IFN treatment. These findings suggest that a small amount of HBV remained in the liver of the patients whose hepatic HBV DNA became negative by usual Southern blot hybridization method.
    View full abstract
    Download PDF (902K)
  • The rate of development of post-transfusion hepatitis and its advancement to chronic hepatitis at Chiba University Hospital, serial change from 1982 to 1987
    Susumu TAKANO, Masao OMATA, Masao OHTO, Yasuhisa MATSUYAMA
    1989 Volume 30 Issue 11 Pages 1558-1565
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1558
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Two thousand five hundred ninety-six consecutive patients who received blood transfusion for the first time within one week and had no liver dysfunction brfore transfusion had been selected from 8637 patients who received blood transfusion at the hospital between 1982 and 1987. GPT abnormal values are most frequently detected at the period from 43rd to 60th after transfusion. GPT maximum values above 80 were detected in 30.5% of all the patient. According the diagnostic of The Japanese Society of Gastroenterology, 205 patients (10.3%) developed definite post-transfusion hepatitis and 246 patients (12.4%) developed probable one. Two hundred and seventeen patients from 451 acute hepatitis patients were followed over 6 months after development of disease. Fifty-eight (44.6%) with definite post-transfusion hepatitis and 19 (21.8%) with probable one progressed to chronic hepatitis. Although 605 patients were excluded because of the short incubation period (<7days) by the diagnostics, 87 patients (29.9%) developed to chronic from 291 patients followed over 6 months from this group.
    View full abstract
    Download PDF (1707K)
  • Natural history of HBeAg positive Hepatitis B virus carrier infants with a special regard to HBsAg subtype
    Norio HORIIKE, Yasuyuki OHTA, Morikazu ONJI, Yasushi OGAWA, Kojiro MIC ...
    1989 Volume 30 Issue 11 Pages 1566-1570
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1566
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Seroconversion (SC) from HBeAg to anti-HBe and s-GPT in 53 infants with HBeAg positive Hepatitis B Virus (HBV) carriers after either horizontal or vertical infection of HBV was observed for a mean period of 8.6 years. Thirty-five infants were male, 18 were female. The age was 5.0±1.8 (mean± S.D.) years.
    The subtype of HBsAg, adr, ayw, adw carriers were 21, 28, 4 infants, respectively. SC was observed in 27 of 53 (51%) infants for 8.6 years (5.9% yearly). In vertical infection infants, SC was occured in 4 out of 8 (50%) infants, the rate of which is same to those of horizontal infection. In either male or female, yearly SC rate were 5.4%, 7.2%, respectively. In the type of adr, ayw, adw carriers, yearly SC rate were 5.1, 6.4, 8.1%, respectively. There was no significant differences among different subtypes. SC was occured yearly in similar rate from 8 years onward. Anti-HBe rate was 78% by 17 year old age.
    View full abstract
    Download PDF (283K)
  • A long term effect of recombinant interleukin 2 for HBeAg-positive chronic hepatitis
    Mitsuhiro TERADA, Masashi UNOURA, Eiki MATSUSHITA, Yutaka INAGAKI, Shu ...
    1989 Volume 30 Issue 11 Pages 1571-1577
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1571
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Recombinant interleukin 2 (rIL-2) was administered to 20 patients with HBeAg-positive chronic hepatitis. Ten patients were received 250 U per day of rIL-2 for 28 days intravenously and another ten patients were received 750 U per day of rIL-2 for 28 days intravenously.
    In patients treated with 250 U, HBeAg became negative in 2 cases (20%) and HBeAg became positive in 1 cases (10%) within 18 months. In patients treated with 750 U, HBeAg became negative in 6 cases (60%) and HBeAb became positive in 3 cases (30%) within 18 months. The younger patients with increased mean percent change from baseline level (100%) of s-GPT and decreased mean percent change from baseline level (100%) of DNA-P activity transiently during therapy showed higher incidence of HBeAg cleared. Fever, malaise, anorexia, headache, diarrhea, lymphocytosis and eosinophilia were observed transiently during therapy. But these symptoms did not necessitate discontinuation of therapy.
    These results suggest that rIL-2 therapy is effective for HBeAg-positive chronic hepatitis, and it is more effective for the younger patient received 750 U per day for 28 days and with significantly increased mean percent change from base line level (100%) of s-GPT and decreased mean percent change from baseline level (100%) of DNA-P activity transiently during therapy.
    View full abstract
    Download PDF (377K)
  • Clinical significance of anticentromere antibody in primary biliary cirrhosis
    Naoya YOSHIDA, Yasukiyo SUMINO, Yukihisa UENO, [in Japanese], Minoru S ...
    1989 Volume 30 Issue 11 Pages 1578-1583
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1578
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Serum anticentromere antibody (ACA) was measured in 123 cases of various chronic liver diseases and especially in primary biliary cirrhosis (PBC), the relationship between the positiveness of ACA and symptom, laboratory data, histology and clinical course was studied. Subjects were 123 cases of chronic liver disease, 25 cases of PBC, 11 cases of lupoid hepatitis and 87 cases of other chronic liver diseases (73 of viral and 14 of alcoholic). Prevalence of ACA was highest (44%) in patients with PBC compared with other chronic liver disease.
    In PBC patient, most ACA positive cases were asymptomatic and complicated with extra hepatic symptoms of CREST syndrome (82%) and showed low titer of antimitochondria antibody (AMA), low levels of serum IgM and bilirubin, gradually progressive clinical course, histologically mild changes, and prognosis was suspected good compared with ACA negative cases. Therefore, in ACA positive cases there might be a distinct of PBC different from that in ACA negative cases.
    View full abstract
    Download PDF (365K)
  • Effects of transforming growth factor-β1 on c-myc expression and cell proliferation in human hepatocellular carcinoma cell lines
    Shinji TAMURA, Sumio KAWATA, Nobuyuki ITO, Kenji TAKAISHI, Ryuzo SAITO ...
    1989 Volume 30 Issue 11 Pages 1584-1588
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1584
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Effects of transforming growth factor-β1 (TGF-β1) on the cell proliferation and DNA synthesis in human hepatocelular carcinoma cell lines, PLC/PRF/5 cells and Mahlavu cells, were studied. To clarify the mechanisms of anti-proliferative action of TGF-β1, we also investigated the effects of TGF-β1 on the expression of c-myc, one of competence genes, in these cell lines. TGF-β1 supressed the cell proliferation and DNA systhesis in PLC/PRF/5 cells but did not in Mahlavu cells. TGF-β1 markedly supressed c-myc expression in PLC/PRF/5 cells but had no effect in Mahlavu cells. These results indicated that TGF-β might suprress cell proliferation by reducing c-myc expression.
    View full abstract
    Download PDF (580K)
  • Clinical evaluation of serum concentration and fucosylation index of AFP, PIVKA-II, sialyl SSEA-1 (SLX), CA-50 and Dupan-2 for the ciagnosis of hepatocellular carcinoma
    Makoto OGURO, Yutaka AOYAGI, Atsushi SAITOU, Kentarou IGARASHI, Yasufu ...
    1989 Volume 30 Issue 11 Pages 1589-1595
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1589
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Serum concentration of AFP, PIVKA-II, sialyl (SSEA-1 (SLX), CA-50 and Dupan-2 was studied in 60 patients with hepatocellular carcinoma (HCC), 70 with benign liver diseases and 25 with carcinoma metastatic to the liver. The fucosylation index of AFP was also determined in AFP positive sera. Positive reactions were noted in the following percentages of sera from HCC by AFP, 80; PIVKA-II, 53; and SLX, 30. The specificities of AFP, PIVKA-II and SLX in benign liver diseases were 81, 97 and 97%, respectively. Measurement of serum AFP in combination with fucosylation index increased the specificity from 81 to 91%. On the other hand, CA-50 and Dupan-2 were not useful for differentiating HCC from benign liver diseases. It was concluded that simultaneous measurements of AFP, PIVKA-II and SLX enable us to diagnose 88% of patients with HCC serologically.
    View full abstract
    Download PDF (408K)
  • Mechanism of the fibrous capsular formation surrounding hepatocellular carcinoma
    Immunohistochemical analysis
    Takuji TORIMURA
    1989 Volume 30 Issue 11 Pages 1596-1605
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1596
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    This study was carried out to clarify the mechanism of the fibrous capsular formation surrounding hepatocellular carcinoma (HCC).
    Hepatocytes near by the capsule were compressed by the expansive growth of HCC. There were many cells and vessels at the nontumorous side of the capsule and in the nontumorous liver parenchyma. Most of those vessels had basement membrane containing type IV collagen and laminin produced by endotherial cells.
    The thin capsule appeared in the early stage of capsular formation consisted of type III collagen produced by fibroblasts, Ito cells and hepatocytes. The nontumorous side of the thick capsule consisted of type III collagen. On the other hand, the tumorous side of the thick capsule mainly consisted of type I collagen produced by fibroblasts, Ito cells and hepatocytes.
    Moreover, the capsule surrounding HCC seemed to play an important role in protecting the nontumorous liver parenchyma against HCC.
    View full abstract
    Download PDF (5020K)
  • An assessment of four-year survived unresectable hepatocellular carcinoma: A comparative study with the cases which died within two years after treatment
    Ken YAMASHITA
    1989 Volume 30 Issue 11 Pages 1606-1616
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1606
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Fourteen cases with unresectable hepatocellular carcinoma (HCC) which survived more than four years after treatment were studied. In 11 cases of them with tumor size below 3cm, clinicopathological features were compared with 18 cases with same size, which survived for less than 2 years after treatment, retrospectively. The following results were obtained. 1) The longest survival time was 6 years and 5 months after arterial chemotherapy by one shot injection of anticancer agents. 2) Tumor size in 11 out of 14 cases which survived more than 4 years was below 3cm, and the grade of cell atypism was shown to be grade I-II and II according to Edmondson-Steiner's classifiction. On the other hand, in 7 out of 11 cases, which survived less than 2 years and underwent histological examination, the grade of cell atypism was shown to be grade II-III and III. 3) In 7 out of 14 cases, HCCs were based on alcoholic liver disease, and all of them had stopped drinking after treatment. 4) In the cases which survived more than 4 years. there were good response of the tumor to the initial treatment and multidisciplinary treatments were also performed. These results suggest that there are factors of long-survived cases with unresectable HCC, such as well differentiated type of cell atypism, HCC based on alcoholic liver disease, and moreover cessation of drinking after treatment, and good response to initial and multidisciplinary treatments.
    View full abstract
    Download PDF (2718K)
  • The outcome of partial hepatic resection for small liver cancer
    Noboru MIICHI, Hisashi MIMURA, Keisuke HAMAZAKI, Hiromasa KASHINO, Hir ...
    1989 Volume 30 Issue 11 Pages 1617-1622
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1617
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The prognosis and histopathological conditions of 12 cases of small liver cancer subjected to partial hepatectomy (HrO) were investigated. The cumulative survival rate was 100% for one year, 75% for 2 years and 64% for 3 years. Among the five patients who died within 3 years, three died of non-recurrent hepatic failure, and the prognosis depended on the worsening of the liver dysfunction (liver cirrhosis) as the cancer progressed. Two recurrences out of 12 cases were seen within 2 years postoperatively, and one recurrence occurred in seven cases of TW(+) operations. TW(+) is not always an important factor in recurrences and there appear to be many cases where complete cures can be obtained with HrO. It is more important to prevent postoperative worsening of the liver dysfunction by removing less of the liver depending on the case. In the histopathological examinaitons, fc-inf(-), fc(-) and v(-) cases showed no recurrences, but there was a high rate of recurence in fc-inf(+) and v(+) cases. When attention was focused on the type of growth in the area of advanced infiltration, the recurrent cases were mainly ig, while the non-recurrent cases were mainly eg.
    View full abstract
    Download PDF (2016K)
  • Effect of interferon α or β on prstaglandin E2 synthesis by mouse Kupffer cells
    Norifumi KAWADA, Yasuhiro MIZOGUCHI, Itaru HASEGAWA, Toukan SHIN, Hiro ...
    1989 Volume 30 Issue 11 Pages 1623-1628
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1623
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Both interferon (IFN)α and IFN/β are anti-virus agents and recently widely used as therapeutic drugs for chronic hepatitis type B. But little is known whethere they have any effects on liver cells. This time, we studied their effects on prostagland in (PG) E2 synthesis by mouse Kupffer cells. As a result, both IFNα and IFN/β significantly inhibited PGE2 synthesis by mouse Kupffer cells with various treatments. And both IFNα and IFNβ elevated the intracellular cAMP level of mouse Kupffer cells.
    These results indicate that IFNα and IFN/β may regulate PGE2 synthesis by mouse Kupffer cells through their effects on intracellular cAMP levels.
    View full abstract
    Download PDF (384K)
  • A case of primary carcinoid tumor of the liver associated with retroperitoneal teratoma
    Yohko SUGAYA, Hitoshi SUGAYA, Makoto IIJIMA, Kazuhiro YUNOMURA, Hiromi ...
    1989 Volume 30 Issue 11 Pages 1629-1634
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1629
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A 54-year-old female was admitted to our clinic, complaining of general fatigue and abdominal fullness.
    Ultrasonography, CT scan, laparoscopy and angiography showed multiple liver tumors and extrahepatic tumors. Malignant cells were obtained from the liver tumor, but not confirmed of its origin.
    She was died of intrahepatic tumor rupture on 6 months hospital days.
    The autopsy revealed carcinoid tumor of the liver and multiple mature teratomas in the upper retroperitoneum. No primary carcinoid tumor elsewhere was found. Primary carcinoid of the liver is very rare, and this case is the first report which is primary carcinoid tumor of the liver associated with retroperitoneal teratoma to our knowledge.
    View full abstract
    Download PDF (2346K)
  • Expression of MHC class II subregion products in liver of chronic hepatitis B
    Gotaro YAMADA, Kouichi TAKAGUCHI, Hiroshi NISHIMOTO, Michiko TAKAHASHI ...
    1989 Volume 30 Issue 11 Pages 1635-1636
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1635
    JOURNAL FREE ACCESS
    Download PDF (1550K)
  • Color doppler ultrasound images and their types in liver tumors
    Yousuke ARITA, Kazuaki YASUHARA, Jyunji FURUSE, Shoichi MATSUTANI, Mas ...
    1989 Volume 30 Issue 11 Pages 1637-1638
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1637
    JOURNAL FREE ACCESS
    Download PDF (618K)
  • Evaluation of peritoneoscopic view of liver colored with indocyanine green by aimed biopsy
    Masato ABEI, Naomi TANAKA, Hisashi MATSUMOTO, Yasushi MATSUZAKI, Toshi ...
    1989 Volume 30 Issue 11 Pages 1639-1640
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1639
    JOURNAL FREE ACCESS
    Download PDF (678K)
  • Serial changes of human atrial natriuretic peptide and renin-angiotensin-aldosteron system by albumin infusion in patients with liver cirrhosis
    Hitoshi TAKAGI, Seiji SAKURAI, Masahiro UEHARA, Hisashi TAKAYAMA, Tats ...
    1989 Volume 30 Issue 11 Pages 1641-1642
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1641
    JOURNAL FREE ACCESS
    Download PDF (101K)
  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1989 Volume 30 Issue 11 Pages 1643
    Published: November 25, 1989
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.30.1643
    JOURNAL FREE ACCESS
    Download PDF (70K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top