Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 33, Issue 1
Displaying 1-15 of 15 articles from this issue
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  • Analysis of liver histology of chronic non-A, non-B hepatitis treated with interferon
    Michiko TAKAHASHI, Gotaro YAMADA, Toshihiko DOI, Hisashi ENDO, Hiroshi ...
    1992 Volume 33 Issue 1 Pages 1-8
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.1
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    We have treated 74 patients with chronic non-A, non-B hepatitis by interferon every day for 4-8 weeks or three times weekly for 12 or 24 weeks. All patients had liver biopsies before treatment. Fourteen of them had second biopsies within 2 weeks after treatment and 26 of them at 6 months after treatment. Liver biopsies were evaluated by means of Histology Activity Index (HAI) score. In the histology of pre-treatment, complete responders had lower numerical scores in the two categories of HAI: periportal necrosis and fibrosis, than no responders. Between pre- and posttreatment liver biopsies, periportal necrosis and intralobular inflammation significantly regressed.
    Most of patients had improvement of total scores of HAI when second biopsies were performed at the end of treatment. Furthermore, treatment for 12 or 24 weeks had improved total scores for longer tim than treatment for 4-8 weeks.
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  • Evaluation of chemotherapeutic effects in hepatocellular carcinoma based on survival analysis
    Shuichi OKADA, Nobuo OKAZAKI, Haruhiko NOSE, Hisanao OHKURA, Kokichi S ...
    1992 Volume 33 Issue 1 Pages 9-14
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.9
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    Two methods for anti-tumor effects analysis on chemotherapy of hepatocellular carcinoma, tumor regression (≥50%, ≥4 weeks) and decreases of serum level of alpha-fetoprotein (≥50%, ≥4 weeks), were evaluated by survival analysis. One hundred and five patients without prior treatment were received systemic chemotherapy for their unresectable hepatocellular carcinomas. Among them, 8 patients were evaluated as effective by tumor regression rate and 7 patients by decreases of serum level of alpha-fetoprotein. For each of these responders, 3 nonresponders were randomly selected. They matched responders in valuable clinical features. In the group of tumor regression analysis, a median survival length was 17.5 months in 8 responders, and 9.7 months in 24 nonresponders. In the group analyzed by serum levels of alpha-fetoprotein, a median survival length was 18.4 months in 7 responders, and 9.4 months in 21 nonresponders. The survival length of responders was significantly longer than that of nonresponders in both groups. It was concluded that chemotherapeutic effects for hepatocellular carcinoma were effectively analyzed by serial measurement of tumor size and serum level of alpha-fetoprotein.
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  • Pathomorphologic study on tumor vessels of hepatocellular carcinoma
    Osamu EDAMITSU
    1992 Volume 33 Issue 1 Pages 15-20
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.15
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    In order to clarify the pathomorphologic characteristics of the tumor vessels in hepatocellular carcinoma (HCC), 73 resected tumors less than 5cm in diameter were studied. The tumor vessels were classified into type A and type V. The former had muscular wall and resembled to the artery. The latter lacked muscular wall and resembled to the vein. The mean number of type A vessels increased along with an increase of tumor size by 2cm in diameter, but did not increase in the tumors larger than 2cm. Meanwhile the mean number of type V vessels increased along with an increase of tumor size in the tumors larger than 3cm, but it was a few among the tumors smaller than 3cm. The number of type A vessels in HCCs which demonstrated no tumor stain by angiography was fewer than that of HCCs which demonstrated tumor stain.
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  • Lipids of red cell membrane and plasma in patients with alcoholic liver disease
    Kyoko TASHIRO
    1992 Volume 33 Issue 1 Pages 21-27
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.21
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    Lipids in red cell membrane and plasma from 72 patients with alcoholic liver disease (ALD) were compared with those from 90 patients with non-alcoholic liver disease (Non-ALD) using thin-layer chromatography with a flame ionization detector (TLC-Fm) method. Mean corpuscular volume (MCV)and free cholesterol (FC) of red cell membrane were increased in proportion to severity of liver dysfunction. Lipids of red cell membrane were changed in proportion to severity of liver dysfunction in liver cirrhosis. MCV and FC/phospholipid (PL) ratio of red cell membrane in fatty liver (FL) of ALD was higher than that of Non-ALD.
    These results may suggest that membrane fluidity of red cell membrane from ALD is more decreased than Non-ALD. Inner membrane/outer membrane ratio of PL from red cell membrane was more decreased in ALD than Non-ALD, and this may suggest that increased rigidity of red cell membrane in ALD. FC/PL ratio of red cell membrane correlated closely With that of plasma (r=0.65, p<0.01) in ALD.
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  • Experimental induction of allergic liver damage in guinea pigs and analysis of prostaglandins formation by their non-parenchymal liver cells
    Toru KIDA, Yasuhiro MIZOGUCHI, Tougou SHIN, Yuzou ICHIKAWA, Itaru HASE ...
    1992 Volume 33 Issue 1 Pages 28-35
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.28
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    When trinitrophenylated hepatocytes were injected to guinea pigs previously immunized with the trinitrophenilated liver specific lipoprotein (TNP-LSP) through mesenteric vein, a significant liver damage was induced showing a remarkable increase in serum transaminase level and necrosis in liver tissue. The non-parenchymal liver cells prepared from these animals were shown a significantly elevated prOduction of TXB2
    by stimulation with Ca ionophore A23187. The slight increase in 6-keto-PGF1α production was also recognized, suggesting that prostaglandins may participate in the induction of liver injuries in this expeimental model at least partially.
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  • Relationship between cytoskeleton and desmosome in the primary cultured hepatocytes
    Michio MORIMOTO
    1992 Volume 33 Issue 1 Pages 36-43
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.36
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    We evaluated interrelationship of cytoskeleton (CS) and desmosome (DS) in primary cultured hepatocytes using CS disrupting agents.
    After 24 hrs incubation of rat hepatocytes, the mediums were exchanged to the medium containing colchicine (Co) and/or cytochalasin D (CD). The fluorescence microscopy was performed for cytokeratin (CK), desmoplakin (DP), tubulin (Tu) and F-actin. Immunoelectron microscopy was done to observe intermediate filaments (IFs) and DSs.
    In the Co treated cells, microtubules disappeared and Tu was diffusely stained but other CSs and DP were not changed. In the CD treated cells, the disrupted actin bundles formed aggregates, where fluorescence labeling DP often coexisted and the distribution of CK was slightly altered. In the cells treated with Co and CD, the attachment of hepatocytes became loose, in which the distribution of CK in their cytoplasm appeared heterogeneous. Ultrastructural study revealed that the aggregation of actin might result in the concentration of IFs and gold particles labeling DP often coexisted in the aggregates.
    Our results indicate that IFs are connected with microfilaments with the aid of DSs in the cell periphery and microtubules contribute to the distribution of IFs in the cytoplasm.
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  • Tow cases of chronic active hepatitis type C acommpanied with psychiatric symptoms during interferon therapy
    Hideto CHIKAZAWA, Shigetoshi FUJIYAMA, Kiyonori IZUNO, Shin-ichi KAWAN ...
    1992 Volume 33 Issue 1 Pages 44-48
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.44
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    Psychiatric side effects were observed in 2 patients with chronic active hepatitis type C treated with interferon alpha (IFN-α).
    Case 1 was a 44-year-old male. He was treated with 6 MU/day of HLBI. As early side effects of IFN, fever and appetite loss were observed. Lately, anxiety, suicidal ideation and delusion of persecution were occurred. These side effects were protracted about 3 months after the discontinuence of IFN.
    Case 2, a 34-year-old female, was treated with 5 MU/day of IFN-α. At the start of therapy, fever, chills, fatigue and anorexia were appeared, and lately, sleeplessness and irritability were observed.
    These results suggest that we have to take care of these psychiatric side effects on treatment of interferon for chronic hepatitis.
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  • A case of primary biliary cirrhosis (PBC) associated with acute autoimmune hepatitis (AIH)
    Ryoichi ISHIHATA, Isao SHOUJI, Yoshitaka HIRAHARA, Yoshihiro SATO, Yok ...
    1992 Volume 33 Issue 1 Pages 49-53
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.49
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    A 44-year-old woman has suffered from hepatic dysfunction since 1976. In 1981, the patient was noticed to have moderately abnormal levels in transaminase and biliary enzymes along with high levels of IgM.
    In January of 1989, the patient was diagnosed as asymptomatic PBC, because of a presence of anti-pyruvate dehydrqgenas antibody in her serum.
    In October of 1989, she noticed a sudden onset of jaundice, with an elevated values of transaminase, bilirubin, γ-globulin and IgM. At this time, the LE cell phenomenon, antinuclear antibody, anti-DNA antibody, anti-smooth muscle antibody and anti-M2 antibody were turned to be positive except anti-M4 antibody. The biopsied liver revealed the histological findings of chronic active hepatitis with inflammatory cell infiltration, piecemeal necrosis and fibrous dilatation in the portal region along with chronic non-supprative destructive cholangitis-like findings.
    Based on these findings, the patient was diagnosed as asymptomatic PBC associated with AIH. An administration of prednisolone at 40 mg/day improved markedly her symptoms, hepatic function, autoantibody titers and hepatic histological findings in the following two months.
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  • A case of long-term survivor after resection for cholangiocellular carcinoma with tumor thrombus in the right main branch of the portal vein
    Motohide SHIMAZU, Tetsushi ESAKI, Jiro Suzuki, Kazuyoshi KOMORI, Hiros ...
    1992 Volume 33 Issue 1 Pages 54-59
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.54
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    We report a rare case of cholangiocellular carcinoma with tumor thrombus in the right main branch of the portal vein (Vp3) surviving for 6 years 7 months after hepatic resection. A 47 year old male patient underwent extended right lobectomy and tumor thrombectomy for a huge liver tumor with Vp3. Histological examination of the resected specimen disclosed well-differentiated papillary adenocarcinoma compatible with cholangiocellular carcinoma. Factors which may contribute to longterm survival are discussed. It is suggested aggressive surgery may be effective treatment even for such an advanced case as the case presented.
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  • A case of primary sclerosing cholangitis (PSC) with positive serum anti-liver/kidney microsome (LKM) 1 antibody and HCV-RNA
    Yasuro YAMAZAKI, Motonobu SUGIMOTO, Ichiro ASAKURA, Takashi KAWAFUNE, ...
    1992 Volume 33 Issue 1 Pages 60-65
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.60
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    A 40-year-old male was admitted to our hospital for further evaluation of upper abdominal pain, jaundice and abnormality of liver function tests. Laboratory data revealed an elevation of the serum biliary enzymes (ALP: 431mU/m/, γ-GTP: 151mU/m/ and LAP: 95mU/ml), hyper-γ-globulinemia, positive ANA and anti-LKM. Serum Anti-HCV was positive and HCV-RNA was also disclosed to be positive by the PCR method. Abdominal US showed thickening of the common bile duct and slight dilatation of the intrahepatic bile ducts. ERCP showed irregular stenosis of the bile duct around the hepatic hilus and slight dilatation and localized stenosis of the intrahepatic bile ducts. Histopathology of the liver showed an enlargement of potal area due to inflammatory cell infiltration and periductal fibrosis in part. Therefore, the patient was diagnosed as PSC. The present case was thought to be very suggestive on a study of clinical implication of serum anti-LKM.
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  • An autopsy case of gas-containing liver abscess and acute emphysematous cholecystitis after percutaneous transhepatic internal/external biliary drainage
    Takeshi MORIOKA, Hiroshi MAKINO, Toshifumi GABATA, Motoko SASAKI, Yasu ...
    1992 Volume 33 Issue 1 Pages 66-72
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.66
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    We reported an autopsy case of gas-containing liver abscess and acute emphysematous cholecystitis after percutaneous transhepatic internal/external biliary drainage. A 67-year-old man had a history of operation for gastric cancer 2 years ago, and he had been received therapy for diabetes mellitus, hypertension and old cerebral infarction. On May 1990, he was admitted to our hospital because of obstructive jaundice due to a mass at the pancreas head and multiple metastatic liver tumors. After percutaneous transhepatic internal/external biliary drainage, multiple gas-containing liver abscess and acute emphysematous cholecystitis were noted on a plain film of the abdomen and CT scan. Ultrasound guided percutaneous drainage was done, but he died of DIC and massive gastrointestinal bleeding. Autopsy findings revealed that a mass at the pancreas head was a recurrence of gastric cancer and liver metastases were secondarily infected with gas-forming organism. So far as we know, this case is the first report on assoc ation between gas-containing liver abscess and acute emphysematous cholecystitis.
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  • Comparisons of three methods extracting HCV RNA from serum and primers for cDNA synthesis.
    Yoko SAKAI, Kazuaki CHAYAMA, Akihito TSUBOTA, Yasuji ARASE, Satoshi SA ...
    1992 Volume 33 Issue 1 Pages 73-74
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.73
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1992 Volume 33 Issue 1 Pages 75
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.75
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1992 Volume 33 Issue 1 Pages 76
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.76
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1992 Volume 33 Issue 1 Pages 77-119
    Published: January 25, 1992
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.33.77
    JOURNAL FREE ACCESS
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