Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 36, Issue 3
Displaying 1-9 of 9 articles from this issue
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  • Stimulation of migration and proliferation of cultured Ito cells by basic fibroblast growth factor
    [in Japanese], Sumio WATANABE, Miyoko HIROSE, Nobuhiro SATO
    1995 Volume 36 Issue 3 Pages 139-143
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.139
    JOURNAL FREE ACCESS
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    Ito cells are accumulated in the lesion of liver fibrosis in clinical and experimental conditions. However, the detail mechanism of Ito cell accumulation is still unknown. In this study, we examined the effects of basic fibroblast growth factor (bFGF) on Ito cell migration and proliferation using primary cultured rat Ito cells.
    Ito cells were prepared from a female Wistar strain rats (bw 200-250g) and were inoculated on plastic culture dish and cultured in DMEM with 10% fetal calf serum for 5 days. Migration and proliferation were assessed with or without bFGF (1-100ng/ml) using time-lapse VTR and BrdU staining. Cultured Ito cells showed spontaneous migration and proliferation. These processes were significantly accelerated by bFGF in a dose-dependent manner. In conclusion, bFGF might play a role in the accumulation of Ito cells in the lesion of liver fibrosis.
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  • Interleukin-8 produced by human hepatocellular carcinoma cell lines has an angiogenic activity
    Yukihiro SHIMIZU, Masami MINEMURA, Takashi TSUKISHIRO, Kazuhiko OKADA, ...
    1995 Volume 36 Issue 3 Pages 144-150
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.144
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    Large amount of IL-8 was found to be produced by five human liver tumor cell lines, and the production was augmented by the addition of IL-1β or TNF-α, but not by IFN-γ. Northern blot analysis demonstrated that IL-8mRNA expression was increased in the presence of IL-1β or TNF-α. Reverse transcription polymerase chain reaction showed that all hepatocellular carcinoma (HCC) tissues examined in this study expressed IL-8mRNA. In vitro analyses using human umbilical vein endothelial cells (HUVECs) demonstrated that conditioned medium of PLC/PRF/5 cells as well as recombinant IL-8 stimulated the proliferation of HUVECs in a dose-dependent manner, and the stimulatory effect was partially inhibited by the addition of neutralizing antibody against IL-8. Our present data indicate that IL-8 produced by HCC cell lines has an angiogenic activity.
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  • A case of the giant liver cell adenoma
    Review of Japanese literatures
    Mikako TAKAHASHI, Satoshi NAKANO, Isao TAKEDA, Takashi KUMADA, Keiichi ...
    1995 Volume 36 Issue 3 Pages 151-157
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.151
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    A case with the giant liver cell adenoma was reported. The patient was an apparently healthy 23-year-old female with no history of drug intake. Physical examination revealed no abnormalities except for the presence of a large mass at the epigastrium. Ultrasonogram, CT and MRI revealed large mass in the left hepatic lobe. Angiographic finding was compatible with liver cell adenoma, with capsular arteries. Liver scintigram showed cold spot in the same area.
    The surgical specimen showed large dark red tumor measuring 22×20×12cm. The tumor was composed of cords and sheets of well differentiated clear hepatocyte and these mostly resembled to normal hepatocyte histologically.
    Only 53 cases with liver cell adenoma have been reported in Japanese literature till now, and the large one in the left lobe such as over 21cm in diameter was reported only this case.
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  • A case of liver hemangioma with arterioportal shunt presenting atypical manifestations mimicking hepatocellular carcinoma
    Junichi OKANO, Yoshikazu MURAWAKI, Yutaka HORIE, Takeaki SUOU, Hironak ...
    1995 Volume 36 Issue 3 Pages 158-161
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.158
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    A 65-year-old man with a history of C viral liver cirrhosis was pointed out 15mm space occupying lesion in the S8 segment of the liver on dynamic CT, demonstrating rapid disappearance associated with arterioportal shunt, which is commonly regarded as a pathognomonic sign of hepatocellular carcinoma. However hepatic angiography showed pooling appearance in the S8 segment compatible with liver hemangioma, which atypically associated with arterioportal shunt. To our knowledge, such an atypical liver hemangioma with arterioportal shunt mimicking hepatocellular carcinoma on dynamic CT is rare in the literature.
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  • Liver cell adenoma with marked fatty degeneration
    A case report
    Hajime TSUNODA, Hideki FUJII, Kaoru NAGAHORI, Masayuki YAMAMOTO, Yoshi ...
    1995 Volume 36 Issue 3 Pages 162-170
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.162
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    A 39-year-old housewife was admitted to our hospital with an asymptomatic tumor in the lateral segment of the live. She had no oral contraceptives and other drugs. Follow up for her on that tumor had been made for three years prior to this admission by abdominal ultrasonography (AUS). The tumor developed from 1.8cm to 2.8cm in diameter with a 572-day doubling time. AUS showed hyperechoic, homogeneous and irregular shaped mass. The tumor was demonstrated as a low density area on plain computed tomogram (CT) and slightly enhanced area on enhanced CT. Magnetic resonance imaging (MRI) showed a high intensity and isointensity area on T1 and T2 weighted images respectively. Angiography indicated that the lesion had faint staining. A laterla segmentectomy of the liver was performed with strong suspicious of a well differentiated hepatocellular carcinoma. The pathological findings revealed it a liver cell adenoma with marked fatty degeneration. The patient has no sign of recurrence now 4 yers after surgery.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1995 Volume 36 Issue 3 Pages 171-172
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.171
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1995 Volume 36 Issue 3 Pages 173-174
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.173
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1995 Volume 36 Issue 3 Pages 175
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.175
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1995 Volume 36 Issue 3 Pages 176-193
    Published: March 25, 1995
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.36.176
    JOURNAL FREE ACCESS
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