Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 37, Issue 11
Displaying 1-16 of 16 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1996 Volume 37 Issue 11 Pages 617-619
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.617
    JOURNAL FREE ACCESS
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  • Development of RT-nested PCR for specific detection of hepatitis G virus
    Hirofumi NIITSUMA, Motoyasu ISHII, Tomoo KOBAYASHI, Chiaki SUZUKI, Koj ...
    1996 Volume 37 Issue 11 Pages 620-625
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.620
    JOURNAL FREE ACCESS
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    A newly discovered hepatitis virus termed GBV-C or HGV was isolated from patients with chronic non-A, non-B, non-C hepatitis. Since the nonstructural region 3 of the genome of GBV-C virus has been sequenced, Simons et al, have developed a method for detecting this virus with the polymerase chain reaction plus Southern blot hybridization with a probe specific for this region. We found the primers they used reacted also with HCV genotype 2a. Since full-length genome of HGV, which is supposedly the same virus as GBV-C, has also been sequenced recently, we constructed primers specifically hybridizing to HGV. Using these primers, all 5 patients infected with HGV showed positive and 9 patients infected with HCV genotype 2a showed negative. These results prove the primers constructed in this study are specific for the detection of HGV without supplementation of Southern blot hybridization.
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  • Clinical significance of the globus pallidus signal intensity ratio in patients with liver cirrhosis
    Motoh IWASA, Noriko KAWAMURA, Kiyohiko HIRANUMA, Masahiro NAKAYABU, At ...
    1996 Volume 37 Issue 11 Pages 626-631
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.626
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    The object of this study was to evaluate the clinical value of the globus pallidus signal intensity ratio for the subclinical detection of hepatic encephalopathy. This study comprised 25 patients with liver cirrhosis without overt hepatic encephalopathy. There was a high frequency (56%) of patients exhibiting increased signal in the globus pallidus. The pallidal signal was related to the severity of the liver disease. The auditory brain stem reaction was not correlated with the pallidal intensity and laboratory parameters. During the follow-up study, 3 out of 5 patients presenting overt hepatic encephalopathy showed strong pallidal signals. The results of this investigation suggest that abnormal globus pallidus signal may constitute a useful method for the subclinical detection of hepatic encepalopathy.
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  • A case of pre-C mutant type B chronic hepatitis with S mutation found to become HBs-Ag-negative after acute aggravation
    Sadamu HOMMA, Tatsunobu KARASAWA, Tomonobu KAWABE, Seika SHIMADA, Shig ...
    1996 Volume 37 Issue 11 Pages 632-637
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.632
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    The patient was a 48-year-old male. Examination performed in July 1990 indicated hepatic dysfunction, and serological tests showed the patient to be HBs-antigen-positive, HBe-antigen negative and anti-HBe-antibody-positive. In May 1991, in the absence of any specific inducing factor, marked elevatoin of the transaminase levels was detected. Analysis of the RFLP method revealed that the patient was infected by HBV pre-C mutant in which codon No. 28 in the pre-C region of the HBV genome was altered from TGG to TGA. After hospitalization, there was no development of hepatic failure, and the transaminase values showed transient elevation and then returned to normal. A liver biopsy yielded findings of CAH2b. After the acute aggravation, the HBs antigen level was continuously low, and it became negative after about 1.5 years, in October 1992. The PCR method also showed that the patient had became negative for HBV-DNA, and the histological findings for the liver were also strikingly improved. It was concluded that there had been clinical cure of the hepatitis. However, the patient remained negative for anti-HBs antibody, and for this reason analysis was performed of the genes in the HBs antigen region. It was found that there has been substitution and insertion of several kinds of amino acids in the HBs antigen protein.
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  • A case of autoimmune hepatitis with positive anticentromere antibody associated with a limited type of scleroderma and chronic thyroiditis
    Kenji OHMOTO, Ichiro MIYAKE, Yasutaka IGUCHI, Seiichi OHNO, Yasuhiro M ...
    1996 Volume 37 Issue 11 Pages 638-644
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.638
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    A 60-year-old female was admitted to our hospital because of jaundice with complaints of general fatigue and anorexia. She did not drink alcohol or take medicine. On admission, liver fucntion tests revealed elevation of total bilirubin and transaminase, concomitantly with hypergammaglobulinemia. Virus markers were negative for hepatitis A, B and C. Serum antinuclear antibody and anticentromere antibody (ACA) were positive, but LE cells were not detected. A liver biopsy specimen showed chronic active hepatitis. Thereafter, 30mg prednisolone was prescribed and rapid improvement was observed in transaminase, total bilirubin and gammaglobulin.
    She had also been aware of Raynaud's phenomenon for a few years and complained of sclerodactylia, which were features of a limited type of scleroderma. In addition, serological examination showed high antithyroglobulin and antimicrosome antibody titers. Further studies of her thyroid function, revealed that she suffered from occult chronic thyroiditis.
    The coexistence of autoimmune hepatitis with a limited type of scleroderma and chronic thyroiditis is quite rare. ACA was detected in her serum. ACA seemed to be related to the pathogenesis of these diseases.
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  • A case of autoimmune hepatitis positive for HCV and HGBV-C/HGV RNA
    Minoru SHIBATA, Yukihisa UENO, Minako HIJIKATA, Reiko MAKINO, Toshiyuk ...
    1996 Volume 37 Issue 11 Pages 645-650
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.645
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    A 50-year-old female received a blood transfusion at the age of 19 when she had surgery for lung tuberculosis. Liver damage was found at the age of 29. In 1986, she was admitted to our hospital and a liver biopsy specimen showed chronic active hepatitis. In 1988, she was diagnosed as having autoimmune hepatitis because serum immunoglobulin G concentration was high and anti-nuclear antibody was positive. The liver biopsy performed in 1994 showed the same findings as the previous one. We used reverse transcription of PCR to determine that she was positive for hepatitis C virus RNA in 1991 and that she was positive for HGBV-C RNA in 1995. We used the primers deduced from NS-3 (helicase-1) (Yoshiba, et al), NS-5 (Linnen, et al), and NS-3 (helicase-2) and 5' untranslated regions (Hijikata, personal communication) for detecting HGBV-C/HGV RNA. All these primers gave positive results. According to the international diagnostic criteria for autoimmune hepatitis this patient was assigned 11 points and categorized as probabie autoimmune hepatitis. She was positive for HLA-DR2. Although we do not know the exact relationship between hepatitis viruses and autoimmune hepatitis, HCV and HGBV-C/HGV may have triggered autoimmune hepatitis in this patient.
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  • A case of anti-mitochondrial antibody-negative asymptomatic primary biliary cirrhosis
    Keiji NAKASHO, Takashi NISHIGAMI, Hitoshi YASOJIMA, Kunio UEMATSU, Koj ...
    1996 Volume 37 Issue 11 Pages 651-658
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.651
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    A case of anti-mitochondrial antibody-negative asymptomatic primary biliary cirrhosis (PBC) associated with autoimmune hepatitis (AIH) was reported.
    A 52-year-old woman was admitted to our hospital for evaluational investigation of liver dysfunction. Blood chemistry on admission showed only mild abnormality in the level of γ-glutamyl transpeptidase. Serum levels of IgM and IgG were also elevated. Immunological examination showed that anti-nuclear antibody (discrete speckled: ×640), anti-centromere antibody (×1280) and anti-smooth muscle antibody (×320) were present in serum, while LE test and LE cell phenomenon were negative. On the other hand, anti-mitochondrial antibody (AMA) and anti-pyruvate dehydrogenase complex (PDH) antibody were not detected in serum. Serum virus markers for hepatitis B and C were negative. In a biopsy specimen from the liver, histological features of chronic active hepatitis including piecemeal necrosis and spotty necrosis were observed. In addition, histological features of chronic nonsuppurative destructive cholangitis and disappearance of interlobular bile ducts were concomitantly present.
    This case appeared to be noteworthy of discussing AIH overlapping with PBC.
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  • A case of primary squamous cell carcinoma of the liver associated with Hepatitis C virus antibody positive liver cirrhosis
    Morihiro OKADA, Kazuaki KAMISAKA, Mitsuhiro TERADA, Fuyuhiko YAMAMURA, ...
    1996 Volume 37 Issue 11 Pages 659-664
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.659
    JOURNAL FREE ACCESS
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    We report a rare case of primary squamous cell carcinoma of the liver associated with Hepatitis C virus (HCV) antibody positive liver cirrhosis. A 66-year-old male complained of general malaise. He had been suffering from HCV antibody positive liver cirrhosis for 10 years. Physical examination revealed a jaundiced man with hepatomegaly and ascites. Ultrasonogram, CT, MRI revealed 5cm space occupying lesion in the left hepatic lobe. The patient's condition progressively deteriorated, and he died on the 38th hospital day.
    Autopsy specimen showed whitish tumor measuring 5×5×7cm in the left hepatic lobe. Microscopically, the tumor was a moderately differentiated squamous cell carcinoma. The liver except for the tumor showed liver cirrhosis.
    Only 18 cases with primary squamous cell carcinoma of the liver have been reported in literature till now. There were no previous reports of hepatic squamous cell carcinoma with HCV antibody positive liver cirrhosis.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 11 Pages 665-666
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.665
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1996 Volume 37 Issue 11 Pages 667-668
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.667
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 11 Pages 669-670
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.669
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    1996 Volume 37 Issue 11 Pages 671-672
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.671
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 11 Pages 673-674
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.673
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1996 Volume 37 Issue 11 Pages 675-676
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.675
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1996 Volume 37 Issue 11 Pages 677-678
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.677
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1996 Volume 37 Issue 11 Pages 679-683
    Published: November 25, 1996
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.37.679
    JOURNAL FREE ACCESS
    Download PDF (730K)
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