Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
Volume 45, Issue 11
Displaying 1-7 of 7 articles from this issue
  • [in Japanese], [in Japanese], [in Japanese]
    2004 Volume 45 Issue 11 Pages 568-580
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
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  • A system to assist in the selection of appropriate antiviral treatment
    Michio KATO, Kenya IYODA, Nobukazu YUKI, Keiji YAMAMOTO, Hajime WAKESH ...
    2004 Volume 45 Issue 11 Pages 581-588
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
    The clinical manifestations of hepatitis B virus (HBV) carrier state vary and are difficult to be objectively determined due to the lack of a clear staging system (criteria). We therefore devised an HBV carrier staging system based on HBV markers, ALT level, age, and cancer risk and also examined clinical treatments based on this staging system. We determined each stage as follows, stage 0 is HBe antigen-positive asymptomatic carriers with persistently normal ALT values, stage I is HBe antigen-positive carriers with abnormal ALT values and 107.6copies/ml and moreof HBV-DNA (younger patients: stage Ia; older patients: stage Ib), stage II is HBe antigen-positive carriers with abnormal ALT values and less than 107.6copies/ml of HBV-DNA (younger patients: stage IIa; older patients: stage IIb), stage III is HBe antigen-negative carriers with 105copies/ml and more of HBV-DNA, stage IV is HBe antigen-negative carriers with less than 105copies/ml of HBV-DNA, and stage V is carriers who no longer have HBs antigens. We believe that this staging system is useful for understanding HBV carrier stage that is related to the proper selection of clinical treatment.
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  • Comparison of HBeAg-positive and HBeAg-negative patients
    Yukiya HAKOZAKI, Kenji HANADA, Teruo NAKAYA, Toshirou KONDOU, Keiji MI ...
    2004 Volume 45 Issue 11 Pages 589-597
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
    It is not unclear if there is a difference in the efficacy of IFN therapy for patients who are HBeAg-positive and for those who are HBeAg-negative. We have conducted a case-series study to know the effects of IFN in patients with chronic hepatitis B who were given a 24-week IFN therapy and followed up for more than 60 months [Mean: 108 months (60∼156)] after IFN treatment.
    We studied 36 patients positive for serum HBV DNA comprising 21 HBeAg-positive and 15 HBeAg negative patients. All patients were injected with 6MU of lymphoblastoid IFN a thrice weekly for 24 weeks.
    The sustained ALT normalization were defined as persistent (>24 months until last vist) biochemical responder (BR) during follow-up period. During 12 months after the end of IFN therapy, the rate of BR was 29% (6/21) of HBeAg-positive patients and 53% (8/15) of HBeAg-negative. More than 60 months after the end of IFN treatment, 10 (48%) of 21 HBeAg-positive patients remained as BR versus 7 (47%) of 15 HBeAg-negative. The rate of the sustained clearance of HBV-DNA was 33% in both HBeAg-positive/negative patients. The ALT normalization at the end of IFN treatment was a significant factor which defines the accumulated rate of sustained ALT normalization (Logrank method, p=0.0047).
    A 24-week IFN treatment is beneficial for HBeAg-positive and HBeAg-negative Patients with chronic hepatitis B.
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  • Tsutomu IWASA, Makoto OKADA, Takeaki SATOH, Makoto NAKAMUTA, Akihide M ...
    2004 Volume 45 Issue 11 Pages 598-602
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
  • Kohichi TAKADA, Shouichi HORITA, Takashi MEGURO, Michiaki HIRAYAMA, Ma ...
    2004 Volume 45 Issue 11 Pages 603-608
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
  • difficulty in discriminating the diagnosis of progressive anemia
    Atsushi HIRAOKA, Kojiro MICHITAKA, Shuuichiro SHIGEMATSU, Toshie MASHI ...
    2004 Volume 45 Issue 11 Pages 609-613
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
  • 2004 Volume 45 Issue 11 Pages 614-626
    Published: November 25, 2004
    Released on J-STAGE: March 31, 2009
    JOURNAL FREE ACCESS
    Download PDF (1693K)
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