Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 46, Issue 12
Displaying 1-5 of 5 articles from this issue
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Review Article
Case Reports
  • A fatal case with liver failure caused by non-alcoholic steatohepatitis
    Satoko UEGAKI, Atsushi TANAKA, Masaki MIKAMI, Masahiro AKASHI, Mitsuhi ...
    Article type: Case Report
    2005 Volume 46 Issue 12 Pages 703-709
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.703
    JOURNAL FREE ACCESS
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    Recently, we experienced a fatal case with liver failure. He has been obese since 6 years old. BMI at age 22, 32 and 34 were 33.0, 49.5 and 55.9, respectively. Liver injury was initially noticed in 2000, and he was admitted to Tokyo Women's Medical University Hospital for further evaluation at age 32. Liver histology revealed pericellular fibrosis, marked steatohepatitis and ballooning degeneration, compatible with NASH.
    At age 34, consciousness disturbance and anuria suddenly developed, and he was transferred to Teikyo University Hospital. Laboratory data on admission demonstrated severe liver and renal failure, and he died soon after admission. Autopsy findings of the liver were compatible with liver cirrhosis, with minimal fat deposition. Based on the previous findings, the etiology of cirrhosis was diagnosed as NASH. It should be notable that NASH in adolescence could result in very poor prognosis like this patient.
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  • A case of alcoholic liver cirrhosis with systemic inflammatory response syndrome
    Toshiyuki OTSUKA, Satoshi HAGIWARA, Hiroki TOJIMA, Kazumi NAGASAKA, Sh ...
    Article type: Case Report
    2005 Volume 46 Issue 12 Pages 710-715
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.710
    JOURNAL FREE ACCESS
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    A 44-year-old male was a habitual alcohol drinker, since he was 18 years of age. His alcoholic consumption increased from December 2004 and he was admitted to our hospital suffering from abdominal turgescence and edema in January 2005. High fever continued and the origin was unknown, and the treatment with antibiotics was not effective. The treatment of edema, pleural effusion and ascites with diuretics and paracentesis was not effective either. We diagnosed the illness as systemic inflammatory response syndrome (SIRS). We diagnosed the cause of SIRS was development of alcoholic hepatitis due to increased alcohol abuse on compensated alcoholic liver cirrhosis. Because of the elevation of serum interleukin-6, we added nafamostat mesilate to antibiotics and diuretics for the treatment. The therapy resulted in a dramatic improvement of clinical symptoms. This case was instructive for understanding of the role of cytokines in alcoholic liver disease.
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Short Communication
  • Efficacy of eicosapentaenoic acid for ribavirin-related anemia and oxidative stress in patients with chronic hepatitis C
    T Ninomiya, Y Yano, K Hamano, H Kato, M Kato, Y Seo, M Kasuga
    Article type: Short Communication
    2005 Volume 46 Issue 12 Pages 716-717
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.716
    JOURNAL FREE ACCESS
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    A major side effect of ribavirin (RBV) is a hemolytic anemia. One of the causes of hemolytic anemia is considered to be oxidative stress to erythrocytes. Recently, a beneficial effect of eicosapentaenoic acid (EPA) for ribavirin-induced anemia has been reported. This study evaluated effects of EPA for ribavirin-induced anemia and thioredoxin (TRX) as an indicator of oxidative stress in chronic hepatitis C patients within 8 weeks. Nighteen of 41 patients who had received interferon/ribavirin therapy were treated with EPA (1800 mg/day) (EPA group). EPA therapy significantly prevented progression of anemia (P<0.01). Moreover, serum TRX levels were significantly decreased in EPA group at 4 weeks (P<0.01). Reduction of oxidative stress by EPA might play an important role for preventing ribavirin-induced anemia.
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Rapid Communication
  • A case of lamivudine-resistant liver cirrhosis type B complicated with breakthrough hepatitis after during 26 months of adefovir dipivoxil therapy
    S Miyase, M Tanaka, K Haraoka, S Fujiyama
    Article type: Rapid Communication
    2005 Volume 46 Issue 12 Pages 718
    Published: 2005
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.46.718
    JOURNAL FREE ACCESS
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    We report a case of both lamivudine (LAM) and adefovir dipivoxil (ADV) resistant liver cirrhosis type B. A 47-year-old woman was hospitalized with chronic active hepatitis with cirrhosis type B. Because her serum alanine aminotransferase (ALT) and hepatitis B virus (HBV) DNA level elevated, she was treated with LAM (100 mg/day). Serum ALT and HBV DNA reductions were observed in 4 months. Nine months after the administration of LAM, HBV DNA and ALT levels re-elevated following the appearance of YMDD mutant (YVDD+YIDD). Additional treatment with ADV (10 mg/day) was commenced, and her serum ALT was decreased during 3 months. However, breakthrough phenomena were observed again 26 months after ADV treatment. This is the first reported case of breakthrough hepatitis associated with both LAM-and ADV-resistant HBV.
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