Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 47, Issue 2
Displaying 1-11 of 11 articles from this issue
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Feature Article
Feature Articles
Editorial
Case Reports
  • A case of acute hepatitis C in which transmission of HCV strain from a patient with chronic hepatitis C was demonstrated
    Hideaki KATO, Etsuro ORITO, Yuji NISHI, Makoto OHYAMA, Makoto NAKAMURA ...
    Article type: Case Report
    2006 Volume 47 Issue 2 Pages 105-112
    Published: 2006
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.105
    JOURNAL FREE ACCESS
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    A 32-year-old male was admitted to Toyokawa City Hospital because of jaundice and dark brown urine. Laboratory findings showed that abnormality of liver function test, and positive for anti-HCV as well as HCV RNA but negative for other virus markers. Thus he was diagnosed as acute hepatitis C. After admission, his clinical course was uneventful and he was discharged 18 days later. He (patient 1) confessed that he shared unsterilized syringe with his friend (patient 2) who had been to our hospital for chronic hepatitis C. Molecular biological analysis was carried out within E1 as well as NS5B region of HCV isolated from the two patients. The nucleotide sequences of E1 and NS5B region of patient 1 were identical to those of patient 2. Phylogenetic analysis was also carried out and revealed that these 2 strains were classified into genotype 2a. These findings indicated that acute hepatitis C was caused by HCV strain transmitted from patient 2 to patient 1 via sharing of unsterilized syringe. Further investigations of HCV infection among intravenous drug users (IDUs) in Japan as well as education to IDUs are required.
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  • A case of advanced hepatocellular carcinoma with tumor emboli in the portal vein showing marked reduction after oral adminisration of UFT, etodolac and Vitamin K2
    Hiroyasu IMANISHI, Masaki SAITO, Jidong CHEN, Weidong LIU, Ryuuji KATA ...
    Article type: Case Report
    2006 Volume 47 Issue 2 Pages 113-118
    Published: 2006
    Released on J-STAGE: November 24, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.113
    JOURNAL FREE ACCESS
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    A 78-year old Japanese woman positive for anti-hepatitis C virus antibody was referred to our hospital because of general fatigue, weight loss and high levels of α-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist II (PIVKA-II). After examinations, she was diagnosed as having advanced hepatocellular carcinoma (HCC) with tumor emboli in the portal vein. Severe esophageal varices due to portal vein tumor thrombi were observed. Oral administration of uracil-tegafur (UFT) was initiated at the dose of 300 mg/day. HCC in the liver, portal vein tumor thrombi and esophageal varices were remarkably reduced after chemotherapy. The patient has been alive with good quality of life for more than 26 months. Etodolac and vitamin K2 were initiated with UFT at the same time. We suppose that etodolac and vitamin K2 may have contributed to antineoplastic effect of UFT in this case.
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