Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 47, Issue 5
Displaying 1-7 of 7 articles from this issue
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Editorial
Original Article
Case Reports
  • A case of autoimmune hepatitis with severe liver fibrosis who was effectively treated with long-term administration of cyclosporin, leading to marked improvement of liver fibrosis
    Kunihiro Takanashi, Kohichi Takada, Junji Kato, Koji Miyanishi, Yutaka ...
    Article type: Case Report
    2006 Volume 47 Issue 5 Pages 245-251
    Published: 2006
    Released on J-STAGE: November 22, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.245
    JOURNAL FREE ACCESS
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    Summary: A 61-year old woman, who was diagnosed as autoimmune hepatitis with severe liver fibrosis had been treated with prednisolone and ursodeoxycholic acid, was referred to our hospital due to repeated aggravation. After administration of cyclosporin, serum aminotransferase was normalized. Liver fibrosis, which was corresponded to cirrhosis at first, was significantly improved 3.5 years after cyclosporin treatment, followed by further improvement to F2 after 6.5 years. Now, she remains stable clinical presentation by continuing therapy with cyclosporin for over 7.5 years.
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  • 2 Cases of Extrahepatic Lesion After Radiofrequency Ablation Therapy for Hepatocellular Carcinoma
    Mitsuro Kanda, Masahiro Suenaga, Yuki Takeuchi, Takaya Miwa
    Article type: Case Report
    2006 Volume 47 Issue 5 Pages 252-257
    Published: 2006
    Released on J-STAGE: November 22, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.252
    JOURNAL FREE ACCESS
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    Recently, in the field of topical therapy for hepatocellular carcinoma the importance of radiofrequency ablation (RFA) is increasing. Generally speaking, this method is low invasive and the occurrence of complications is not so high. However, some reports regarding tumor seeding from the puncture site have been seen, since it requires the usage of puncture needles penetrating directly into the liver parenchyma. Here we report 2 cases of extrahepatic tumor seeding after RFA for hepatocellular carcinoma. Case 1 is a 70's male who had received repetition of RFA for hepatocellular carcinoma. He underwent laparotomy for multiple peritoneal dissemination occurred during follow up care with transcatheter arterial embolization for remaining intrahepatic tumors. Case 2 is a 70's female who received an extirpation of the subcutaneous tumor under local anesthesia due to an implantation at the site of puncture after percutaneous RFA for hepatocellular carcinoma in S3. Although there have been many reports concerning the availability of RFA for hepatocellular carcinoma, it is necessary to observe carefully the long time course of patients who have received RFA, taking the possibility of tumor seeding into consideration.
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  • A case report of advanced hepatocellular carcinoma with pulmonary and adrenal metastases that was treated with chemoradiotherapy
    Sho Takahashi, Hisato Homma, Takehide Akiyama, Shinichi Mesawa, Kazuhi ...
    Article type: Case Report
    2006 Volume 47 Issue 5 Pages 258-265
    Published: 2006
    Released on J-STAGE: November 22, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.258
    JOURNAL FREE ACCESS
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    We report a 77-year-old man was admitted to our institution because of stage III hepatocellular carcinoma (HCC) and HCV-positive liver cirrhosis. Following transarterial chemoembolization (TAE) and radiofrequency ablation (RFA) was performed. 18 months after the first therapy, slight elevation of serum AFP level was pointed out and a metastatic lesion of the left adrenal gland was detected by computed tomography (CT). Another examinations were helpful in diagnosing the tumor as adrenal metastasis of HCC. He wished to be orally administered of UFT (300mg/day) at first, and followed three times TAI (transcatheter arterial chemoinfusion) to some feeding artery was performed, but that lesion had poor tumor stain. A further 5 months later, the tumor keeping progressive, systemic chemotherapy (FP) was carried out. The FP therapy consisted of 5-FU (500mg/body/day on day 1 to day 7/week, continuous infusion) and CDDP (10mg/body/day in 250ml normal saline, infusion for 2 hours, on day 1 and 4/week) for 2 consecutive weeks with a subsequent one-week rest period. After 2 cycles of systemic chemotherapy, adrenal metastasis was no change and lung metastases were regressed. But serum AFP level was additionally elevated, radiotherapy (40Gy/16f) was additively performed. After 5 cycles of combined therapy, adrenal metastasis was markedly regressed and lung metastases were not detectable.
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  • A case of hepatocellular carcinoma with multiple lung metastases effectively treated by orally UFT
    Takeshi Matsui, Kunihiko Tsuji, Hiroyuki Nishimori, Yasuo Sakurai, Jon ...
    Article type: Case Report
    2006 Volume 47 Issue 5 Pages 266-272
    Published: 2006
    Released on J-STAGE: November 22, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.266
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    We reported a case of lung metastases derived from hepatocellular carcinoma (HCC) which completely respond to oral UFT administration. A 60-year-old man suffering from chronic hepatitis C referred to our hospital to investigate a 3cm SOL in segment 3 of the liver in August 2000. He performed radiofrequency ablation therapy with transcatheter arterial embolization for the SOL diagnosed hepatocellular carcinoma because intrahepatic metastasis was suspected in the right lobe of the liver. After 2 years observation, we diagnosed local recurrence of HCC in segment 3 of the liver in 2002. We also concluded a suspicious intrahepatic metastasis as a pseudo-lesion, based on the fact that the size was not changed in these 2 years. He underwent the left lobe hepatectomy for HCC in 2002. In 2004, we identified lung metastases of HCC in bilateral lung field with increasing serum PIVKA-II level but not any recurrences in the liver. We administrated him UFT by 300mg per day under the informed consent. Ten months after administration of UFT, enhanced computed tomography showed the complete response of lung metastases to oral UFT administration and serum PIVKA-II level was normalized.
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Short Communication
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