Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 47, Issue 8
Displaying 1-6 of 6 articles from this issue
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Editorial
Original Article
  • Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide
    Toshinori Abe, Tatsuya Aikawa, Yoshihiro Akahane, Masahiro Arai, Yasuh ...
    Article type: Original Article
    2006 Volume 47 Issue 8 Pages 384-391
    Published: 2006
    Released on J-STAGE: December 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.384
    JOURNAL FREE ACCESS
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    To know the reality of hepatitis E virus (HEV) infections in Japan, quite obscure until a few years ago, we have collected a total of 254 human cases of HEV infection, and analyzed for demographic, epidemiological, and virological characteristics. As a result, we now know [i] HEV has penetrated nationwide from Hokkaido to Okinawa; [ii] hepatitis E is a disease of middle-aged people (approx. 50 years old in average) with a predominance of male over female (approx. 3.5 vs 1); [iii] HEV strains of genotype 3 and 4 are autochthonous in Japan, but the latter is present almost exclusively in Hokkaido; [iv] the older the age the severer the disease; [v] HEV genotype 4 is associated with more obvious and severer clinical manifestations than genotype 3; [vi] no seasonality in its incidence; and [vii] transmission routes remain obscure in most cases (approx. 60%), whereas about 30%, 8%, and 2% are ascribable to zoonotic food-borne transmission, imported infection, and via blood transfusion, respectively.
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Case Reports
  • A case of primary biliary cirrhosis with systemic lymph node enlargement
    Yasuyuki Aisaka, Ayako Urabe, Tomoko Yamasaki, Hiroshi Kohno, Shiomi A ...
    Article type: Case Report
    2006 Volume 47 Issue 8 Pages 392-397
    Published: 2006
    Released on J-STAGE: December 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.392
    JOURNAL FREE ACCESS
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    A 60 year-old female was hospitalized for chronic liver injury. Elevation of serum bile duct enzymes and the presence of anti-mitochondrial M2 antibody (36IU/l) supported the presence of primary biliary cirrhosis (PBC). Biopsy of left axillary lymphnode was performed for swollen superficial and peri-hepatic lymph nodes, and revealed reactive lymph-follicular hyperplasia. Laparoscopy demonstrated a rough liver surface but neither a reddish patch nor a ditch-shaped indentation. PBC was histologically proven by the findings of lymphocyte infiltration, granuloma formation and regenerative change of bile ductule epithelium in the portal tracts. The size of superficial lymph nodes was reduced with the improvement of serum liver enzymes during ursodeoxycholicacid (UDCA) treatment, 600mg/day for a year. Reactive lymph-follicular hyperplasia might be associated with the immune response caused by PBC.
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  • A case of liver dysfunction without elevation of serum transaminase induced by 5-Fluorouraci (5-FU) administration for colon cancer with liver metastasis
    Katsuhiko Matsumaru, Koji Ishii, Noritaka Wakui, Masao Shinohara, Hide ...
    Article type: Case Report
    2006 Volume 47 Issue 8 Pages 398-404
    Published: 2006
    Released on J-STAGE: December 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.398
    JOURNAL FREE ACCESS
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    A 56-year-old man was referred to our department in April, 2004. He had undergone colorectomy because of colon cancer at our hospital on August 16, 2002. Before colorectomy, liver metastic tumor was observed on abdominal ultrasonogram and computed tomogram. After surgical resection for primary colon cancer, 1500mg once weekly of 5-FU through reserver in common hepatic artery (CHA) was administered intraarterially from September 20, 2002. Serum transaminase levels were measured every month and remained within normal limits. Although serum transaminase levels remained normal during the follow-up period, liver dysfunction and ascites gradually developed. However, these rapidly abated after cessation of 5-FU treatment. The possibility of insidious liver injury, especially in cancer patients receiving long-term treatment, even if the patient has a normal serum transaminase level, should be considered when 5-FU is administered intraarterially or orally.
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  • An autopsy case of a large pedunculated type hepatocellular carcinoma with a sarcomatous component recurred 5 years after initial treatment
    Makoto Irie, Eiji Fujita, Daisuke Morihara, Takashi Tanaka, Hidetoshi ...
    Article type: Case Report
    2006 Volume 47 Issue 8 Pages 405-410
    Published: 2006
    Released on J-STAGE: December 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.405
    JOURNAL FREE ACCESS
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    A 66-year-old man was admitted to our hospital because of general fatigue and abdominal fullness in April 2005. He had a history of hepatocellular carcinoma (HCC) treated with transcatheter arterial embolization five years ago and then, he received interferon monotherapy for hepatitis C virus infection. Serum HCV RNA was completely disappeared after the treatment. Abdominal computed tomography (CT) on this admission showed a large pedunculated type tumor in the right lobe of the liver. The tumor did not show a typical HCC pattern in both dynamic CT and hepatic angiography. Histopathological examination demonstrated that both atypical epitherial cells and sarcomatous cells (SC) were observed in the tumor. Immunohistochemical stainings for cytokeratin (CK)-8, CK-19 and vimentin were also all positive. Therefore, we diagnosed that the tumor is HCC associated with a SC component. We report here a very rare case of a large pedunculated type HCC associated with a SC component.
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