The serum free fatty acid levels were 571±240 μEq/L in patients with chronic hepatitis and 780±240 μEq/L; the serum free fatty acid levels were significantly higher in chronic hepatitis than in chronic hepatitis than in cirrhosis. The elevation of serum free fatty acid in cirrhosis is caused by starvation. The serum free fatty acid levels were significantly decreased after the meal. 200 kcal of a nutritional supplement (Calorie Mate JERRY; Otsuka Pharmace-utical, Japan) was given to the patients before abdominal ultrasonography. The free fatty acids levels were significantly decreased after a nutritional supplement. Calorie Mate JERRY as a nutritional supplement improve metabolic disorder caused by fasting before abdominal ultrasonograhy.
We investigated lipid metabolism in nine patients with chronic hepatitis C virus (HCV), not responded by previous interferon therapy (IFN), undergoing double filtration plasmapheresis (DFPP) and peginterferon plus ribavirin (PEG·Rib) combination therapy. Three patients were non-responder of previous IFN monotherapy and 6 were PEG·Rib. HCV RNA became negative within 24 weeks in 5 out of 9. In the HCV RNA negative group, Triglyceride (TG) and Total-Cholesterol (T-Chol) or LDL-Chol levels increased gradiently after DFPP and were higher than those before treatment, but not in HCV positive group. DFPP plus PEG·Rib combination therapy might not only produce a reduction of HCV but also improve the environment of lipid metabolism effective for PEG·Rib during the early stage of treatment.