Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 50, Issue 8
Displaying 1-10 of 10 articles from this issue
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Feature Article
Original Article
  • Preliminary dose finding study of Erythropoietin for Peginterferon/Ribavirin-induced anemia in Japanese patients with hepatitis C
    Fumihiko Kanai, Ryosuke Tateishi, Yasuo Tanaka, Shuichiro Shiina, Haru ...
    Article type: Original Article
    2009 Volume 50 Issue 8 Pages 427-436
    Published: 2009
    Released on J-STAGE: September 04, 2009
    DOIhttps://doi.org/10.2957/kanzo.50.427
    JOURNAL FREE ACCESS
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    Combination therapy with PEG-IFN and RBV for HCV infection often causes anemia, prompting RBV dose reduction/discontinuation. The aim of this study was to determine the optimal dose of erythropoietin (EPO) to increase Hb in anemic HCV-infected Japanese patients, and to assess whether EPO could maintain RBV dose and improve QOL. Nine patients who developed anemia were injected 12,000, 24,000 or 36,000 IU EPO subcutaneously once weekly for 12 weeks. The mean changes from baseline Hb levels at week 12 were +0.9 g/dL (12,000 IU), 1.1 g/dL (24,000 IU), and 1.8 g/dL (36,000 IU), respectively. RBV doses were maintained during EPO injection, and QOL scores of SF-36 and FACT-Anemia were improved significantly. EPO was well tolerated, and adverse events were not observed. EPO maintained RBV, and improved QOL and Hb in anemic patients. 24,000 to 36,000 IU epoetin beta once weekly appeared to be optimal dose for Japanese patients.
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Case Reports
  • A case of fulminant hepatitis in which negative arterial flow and increased portal flow were observed by ultrasound Doppler imaging: Featuring histological findings of vessels in the portal tract
    Hitoshi Tochio, Yukihiro Imai, Hirohumi Shirane, Naoya Kimoto, Akihiko ...
    Article type: Case Report
    2009 Volume 50 Issue 8 Pages 437-444
    Published: 2009
    Released on J-STAGE: September 04, 2009
    DOIhttps://doi.org/10.2957/kanzo.50.437
    JOURNAL FREE ACCESS
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    We experienced a case of fulminant hepatitis of 54 years old male by hepatitis virus type B. Increased portal blood flow signal (maximum velocity: 46.3 cm/s) and no arterial blood flow signal were observed by ultrasound Doppler imaging. Histopathological examination of necropsy liver specimen showed massive necrosis. No obstructive finding such as thrombosis was observed in vessels of portal tracts. The number of arterioles observed per portal tract (n=20) was 1.6±0.9 (0∼4). The ratio of arteriolar diameter for that of portal venules was 0.18±0.20 (0.03∼0.72). The number of arterioles was fewer, and arteriolar diameter relative to portal venules was smaller than normal in previous report. These histlogical findings were suggested to reflect the peculiar hemodynamics observed by ultrasound Doppler imaging.
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  • A case of PBC-AIH overlap syndrome who developed AIH 8 years after diagnosis of typical PBC
    Ryu Sasaki, Motohisa Akiyama, Shigeyuki Takeshita, Satoshi Miuma, Eisu ...
    Article type: Case Report
    2009 Volume 50 Issue 8 Pages 445-450
    Published: 2009
    Released on J-STAGE: September 04, 2009
    DOIhttps://doi.org/10.2957/kanzo.50.445
    JOURNAL FREE ACCESS
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    A 41-year-old woman who had been diagnosed as PBC 8 years ago (1999) admitted to our hospital due to general malaise and the elevation of serum transaminase level on December 2007. Liver biopsy showed CNSDC on the first admission (1999). However, it showed interface hepatitis in addition to CNSDC on the second admission (2007). According to the IAHG scoring system, her score was 16 points indicating the probable AIH. Therefore, she was diagnosed as PBC-AIH overlap syndrome. We started corticosteroid therapy with 50 mg of prednisolone, then her condition was immediately improved together with the decrease of serum transaminase level. 10 months after, her transaminase level remains normal with 5 mg of prednisolone.
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  • A case of hepatic angiosarcoma that was diagnosable with percutaneous liver biopsy and associated with disseminated intravascular coagulation syndrome
    Tomofumi Miura, Yasunori Tsuboi, Satoshi Yamada, Tsutomu Miura, Masahi ...
    Article type: Case Report
    2009 Volume 50 Issue 8 Pages 451-458
    Published: 2009
    Released on J-STAGE: September 04, 2009
    DOIhttps://doi.org/10.2957/kanzo.50.451
    JOURNAL FREE ACCESS
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    A 68-year-old man visited our outpatient clinic in February 2006 and hospitalized in April 2006 for his progressing anemia. Multiple liver tumors were found by computed tomography and magnetic resonance imaging. These tumors were hard to be diagnosed since contrast enhancement study was out of choice for his allergy. Thus, we performed a needle biopsy using ultrasound under full informed consent. Consequently, these tumors were diagnosed as angiosarcoma since tumor cells showed high-grade atypia and were positive for CD31 immunostaining. Finally, he died due to disseminated intravascular coagulation (DIC) syndrome. The autopsy revealed that he had primary hepatic angiosarcoma with wide-spread tumor embolism of the systemic artery, which caused profound DIC throughout his body. Hepatic angiosarcoma is rare disease but has high malignant potential. Percutaneous liver biopsy seems to be useful and safety in such an instance.
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  • A resected case of primary malignant lymphoma of the liver in patient with primary sclerosing cholangitis
    Tsuyoshi Ichikawa, Shigekazu Takemura, Takahiro Uenishi, Masao Ogawa, ...
    Article type: Case Report
    2009 Volume 50 Issue 8 Pages 459-466
    Published: 2009
    Released on J-STAGE: September 04, 2009
    DOIhttps://doi.org/10.2957/kanzo.50.459
    JOURNAL FREE ACCESS
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    A 80-year-old woman with a complaint of epigastralgia was admitted to our hospital because abdominal computed tomography detected a huge hepatic tumor. White blood cell counts, serum concentrations of C reactive protein, lactate dehydrogenase and alkaline phosphatase elevated. Tumor markers which we examined were within a reference range. Computed tomography showed a 9 cm low-density mass with heterolytic enhancement. There were no abnormalities in examinations of the gastrointestinal tract. The tumor was diagnosed as ICC preoperatively, and lateral segmentectomy was performed. Pathologically, the resected tumor was diagnosed as primary diffuse large B cell type malignant lymphoma of the liver, and noncancerous hepatic tissue was diagnosed as primary sclerosing cholangitis. Postoperative adjuvant chemotherapy was performed, and tumor reccurence dose not occurr at 28 monthes after the surgery.
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Short Communication
  • ARFI: a new non-invasive method for evaluation of liver fibrosis
    Shintaro Takaki, Yoshiiku Kawakami, Takahiro Azagami, Yuki Kimura, Sat ...
    Article type: Short Communication
    2009 Volume 50 Issue 8 Pages 467-469
    Published: 2009
    Released on J-STAGE: September 04, 2009
    DOIhttps://doi.org/10.2957/kanzo.50.467
    JOURNAL FREE ACCESS
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    We evaluate the Acoustic Radiation Force Impulse (ARFI) for the non-invasive assessment of liver fibrosis in chronic liver disease patients, compared with transient electrography (FibroScan®502). Liver stiffness values measured by FibroScan®502 correlates well with liver fibrosis stage (F0-1: 5.5 Kpa, F2: 8.6 Kpa, F3: 10.5 Kpa, F4: 17.8 Kpa). In addition, liver stiffness quantification by ARFI is very well correlated with liver stiffness values by FibroScan®502 (r=0.88, P<0.001). ARFI is considered a new useful tool for assessment of the liver fibrosis with non-invasive methods.
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Rapid Communications
Erratum
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