Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 51, Issue 9
Displaying 1-10 of 10 articles from this issue
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Feature Article
Original Articles
  • Effect of alcohol consumption on the prevalence of fatty liver disease
    Tadashi Doi, Shingo Tanaka, Yasuhiro Sato, Hidetoshi Ohta, Shinya Mina ...
    Article type: Original Article
    2010 Volume 51 Issue 9 Pages 501-507
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.501
    JOURNAL FREE ACCESS
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    The effect of light to moderate alcohol consumption on the prevalence of obesity related fatty liver disease (FLD) is controversial. We analyzed 3185 individuals (male/female: 2243/939) who visited Oji General Hospital Health Checkup Center from January 2008 to December 2008. Multiple logistic regression was used to determine the association between alcohol consumption and FLD. Visceral fat obesity, impaired fasting glucose, and dyslipidemia were associated with increased Odds ratios for the fatty liver. On the other hand, in men, minimal (<20 g) to moderate alcohol consumption (=20 g and <40 g/day) was associated with decreased Odds ratio for fatty liver (FL). In women, however, alcohol consumption was not found to be associated with a decreased Odds ratio for FL. These results suggest that there is a sex difference in the effect of alcohol consumption on the prevalence of FLD and light to moderate alcohol consumption may have preventive effect on the developing obesity related FLD in men.
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  • MR elastography of the liver for diagnosing liver fibrosis
    Utaroh Motosugi, Tomoaki Ichikawa, Hironobu Sou, Katsuhiro Sano, Tsuto ...
    Article type: Original Article
    2010 Volume 51 Issue 9 Pages 508-512
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.508
    JOURNAL FREE ACCESS
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    Purpose: To evaluate the utility of magnetic resonance elastography (MRE) for predicting the stage of liver fibrosis.
    Materials and Methods: This study included 56 patients in whom stage of liver fibrosis was pathologically diagnosed. MRE was performed with a 1.5-T MR scanner and converted to elastograms indicating elasticity (shear modules) in kPa. ROC analysis was performed to estimate the diagnostic performances of MRE to predict liver fibrosis.
    Results: The mean elasticities measured by MRE were 2.1 kPa for F0, 2.7 for F1, 3.1 for F2, 4.2 for F3, and 6.2 for F4. Areas under the ROC curves were 0.97 for ≥F1, 0.95 for ≥F2, 0.96 for ≥F3, and 0.96 for ≥F4.
    Conclusion: MRE is a useful method for predicting liver fibrosis.
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Case Reports
  • A case of autoimmune hepatitis/primary biliary cirrhosis overlap syndrome progressing rapidly to cirrhosis with skin pigmentation and various immunological characteristics
    Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Shin-ichi Aishima, ...
    Article type: Case Report
    2010 Volume 51 Issue 9 Pages 513-520
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.513
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    A 53-year-old Japanese man was found to have a liver dysfunction with a total bilirubin of 3.3 mg/dl, ALT 724 IU/l, alkaline phosphatase 568 IU/l with an elevation of serum IgM while serum levels of IgG, antinuclear antibody (ANA) and anti-mitochondrial antibody (AMA) showed normal. Primary biliary cirrhosis (PBC) was suspected at that time, however, he left the hospital by self-determination. Five years later, he developed liver cirrhosis with jaundice, ascites and skin pigmentation and sclerosis. Antinuclear antibody, negative 5 years before, was now positive at 1: more than 2560. Serum IgG and IgM were elevated. Anti-mitochondrial antibody M2 component, and liver-kidney microsome (LKM)-1 antibody, double strand DNA antibody, platelet-associated IgG, direct-, indirect Coombs tests were also positive. Liver histology revealed cirrhosis. He was diagnosed as having AIH/PBC overlap syndrome due to serologic features. Sequential changes of the titers of several antibodies, laboratory characteristics and clinical symptoms within short durations are discussed.
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  • A case of intrahepatic cholangiocellular carcinoma with sarcomatous change
    Koichiro Yasuda, Takefumi Niguma, Toshiyuki Takagi, Shinichi Fujioka, ...
    Article type: Case Report
    2010 Volume 51 Issue 9 Pages 521-527
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.521
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    An 80-year-old woman complaining of epigastralgia and fever consulted our hospital for the treatment of a liver tumor. Imaging findings showed the obstruction of the left hepatic vein and the left portal vein by an 8-cm multicystic tumor in the left lobe of the liver. An extended left lobectomy was performed. An ill-defined tumor exhibiting central necrosis and associated with cystic dilatation of the peripheral intra-hepatic bile ducts was observed. Microscopically, the diffuse proliferation of short spindle to polygonal cells with irregular nuclei invading most areas of the lesion was observed, with small areas of papillary adenocarcinoma that had spread along the dilated bile ducts. Both types of tumor cells were positive for cytokeratin, and the transition of the adenocarcinoma and sarcomatoid cells suggested a bile duct epithelial origin. The patient was discharged on postoperative day 17. However, lung and brain metastases were detected 2 months after the operation, and the patient died 3 months after the operation. Cholangiocarcinoma with sarcomatous change is very rare; lesions progress rapidly and are associated with a poorer prognosis than typical cholangiocarcinoma. We report a case of cholangiocarcinoma with sarcomatous change.
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Short Communications
  • Comparative study between public and occupational health examinations in Ibaraki Prefecture
    Teruo Miyazaki, Akira Honda, Tadashi Ikegami, Masanori Ito, Yoshifumi ...
    Article type: Short Communication
    2010 Volume 51 Issue 9 Pages 528-530
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.528
    JOURNAL FREE ACCESS
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    We compared the positive- and the screening-rates in HCV-antibody test between public and occupational health examinations in 159,707 and 30,850 individuals, respectively. In the public and occupational examinations, the positive rates were 1.90% and 1.61%, and the relative rates in the under 60-year of age to all positives were 31.8% and 63.7%, while the screening rates were 99.9% and 27.2%, respectively. The positive rate was higher in older and in male in the public examination, while there was no marked difference between genders and between age-ranges in the occupational examination. Establishment of HCV-testing system in all of health examination is desirable for early detection and treatment of HCV infection.
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  • Indirect immunofluorescence and ELISA for testing of antimitochondrial antibodies -Which is better?-
    Ryo Miura, Atsushi Tanaka, Masako Fukami, Yoriyuki Takamori, Hiroshi M ...
    Article type: Short Communication
    2010 Volume 51 Issue 9 Pages 531-533
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.531
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    For Antimitochondrial antibodies (AMA) testing, both indirect immunofluorescense (IF) and ELISA (M2) are currently used. Herein we aimed to suggest which is better for AMA testing in clinical setting. Recent nation-wide surveillances for PBC demonstrated that AMA testing with M2 has been prevailed instead of IF. On the other hand, 3-5% of PBC patients had M2-negative but IF-positive AMA, and these patients might not be diagnosed as PBC if only M2 would have been tested. In another PBC cohort at our hospital we failed to detect any difference between patients with only IF-positive and those with M2-positive. Therefore, M2 should be used for screening for AMA, and if M2 was negative AMA should be reexamined with IF.
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Rapid Communications
  • Duration of HBs antigenemia in patients with acute hepatitis B
    Norie Yamada, Hiroshi Yotsuyanagi, Chiaki Okuse, Kiyomi Yasuda, Michih ...
    Article type: Rapid Communication
    2010 Volume 51 Issue 9 Pages 534-535
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.534
    JOURNAL FREE ACCESS
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    Recently distribution of hepatitis B virus (HBV) genotypes (GT) in the patients with acute HBV infection has been changing. It has been suggested that acute hepatitis caused by GTA HBV becomes chronic more often than that by other genotypes. We studied HBsAg-positive period in 88 patients with various HBV genotypes. HBsAg-positive period in GTA HBV is longer than that in GTB and GTC. HBsAg-positive period exceeded 6 months in 3 of 47 patients with GTA HBV. One of the three patients became chronic. GTA HBV, which is detected more than half of the patients, is related to prolonged or chronic outcome. Universal HBV vaccination program for the prevention of HBV infection should be launched in the near future.
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  • A wild boar-derived hepatitis E virus isolate presumably representing so far unidentified "genotype 5"
    Kazuaki Takahashi, Shuzo Terada, Hiroyuki Kokuryu, Masahiro Arai, Shun ...
    Article type: Rapid Communication
    2010 Volume 51 Issue 9 Pages 536-538
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.536
    JOURNAL FREE ACCESS
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    A peculiar nucleotide sequence of HEV RNA was recovered from a wild boar (Sus scrofa leucomystax ) of male sex with about 10 kg of body weight, captured 1-Feb-2009 in the forest of Tenryu-ku, Hamamatsu, Shizuoka, Japan. The sequence (JBOAR135-Shiz09, accession number AB573435) showed only less than 80% nucleotide identity to so far reported sequences of HEV genotype 1 through 4 (72.7-76.4% vs G1, 75.5% vs G2, 71.2-78.2% vs G3, 74.9-78.2% vs G4) and also to the rabbit HEV isolates recently reported from China (75.5-77.3%). Since the rabbit HEV segregates to genotype 3 in the present phylogenetic analysis (CLUSTALW Unrooted N-J Tree Method), we propose our JBOAR135-Shiz09 isolate as the first member of new genetic group of HEV, "genotype 5".
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  • Non-invasive evaluation method of the liver fibrosis using Real-time Tissue Elastography ∼Usefulness of judgment liver fibrosis stage by Liver Fibrosis Index (LF index)
    Kenji Fujimoto, Michio Kato, Akiko Tonomura, Norihisa Yada, Chie Tatsu ...
    Article type: Rapid Communication
    2010 Volume 51 Issue 9 Pages 539-541
    Published: 2010
    Released on J-STAGE: October 07, 2010
    DOIhttps://doi.org/10.2957/kanzo.51.539
    JOURNAL FREE ACCESS
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    To evaluate the effectiveness of Real-time Tissue Elastography (RTE) in staging of liver fibrosis non-invasively, we performed RTE on 310 patients with chronic hepatitis C (and/or liver cirrhosis) and 15 healthy volunteers. Nine image features were extracted from each RTE image and a multiple regression analysis was then performed to derive the regression equation. This equation calculates Liver Fibrosis Index (LF Index), which in turn predicts F stage of the liver. LF Index not only correlates highly with the F stage (r=0.68) of the liver fibrosis, but also it shows significant differences in LF Index values (p<0.001) between each stage of the fibrosis. Thus, we can conclude that RTE is a promising method to evaluate the liver fibrosis noninvasively.
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