To examine recent trends of acute infection with hepatitis B virus (HBV) in Mito, located in a non-Metropolitan area of Japan, serum samples obtained from 17 patients with acute hepatitis B (AHB) and 243 patients with chronic HBV infection during 2001-2013 were subjected to HBV genotyping. HBV genotype A (GtA) was detected in 3 (1%), GtB in 64 (26%) and GtC in 174 (72%) of patients with chronic HBV infection, while GtA was most prevalent (47%) among the AHB patients. Of note, GtA was found significantly more frequently in AHB patients during 2008-2013 than in those during 2001-2007 (64%vs. 17%, p<0.0001). These increasing trends of GtA HBV infection via sexual transmission emphasize the necessity of preventive education and measures.
We evaluated local control of hepatocellular carcinoma (HCC) treated with Cyberknife, stereotactic body radiation therapy (SBRT). CyberKnife, SBRT system with real-time tumor tracking has good efficacy and low toxicity.54 patients with 67 liver-confined HCC were treated with Cyberknife. Fiducials were implanted in the liver before treatment and were used as markers to track the lesion's movement. A total dose of 30 to 60 Gy in three fractions was prescribed to the 80%isodose line. Treatment response was evaluated by RECICL, CR: 82%, PR: 16%, PD: 2%. The local control rate was 92.3%at 1 year. Cyberknife was a safe, effective, noninvasive option for patients with HCC.