Observation of liver fibrosis in patients with nonalcoholic steatohepatitis (NAFLD) is important; however, biopsy is gold standard for assessing liver fibrosis, and has risk of critical complications. New non-invasive examination, a measurement of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) was invented. We investigated the significance of measuring serum WFA+-M2BP for observing hepatic fibrosis in patients with NAFLD by analyzing repeated biopsied cases. 46 patients were enrolled, and between two biopsies, liver fibrosis of 15 patients was unchanged, 18 patients worsened, and 13 patients improved. In unchanged group, serum WFA+-M2BP did not change, but worsened group tended to increase and improved group decreased. From present data monitoring serum WFA+-M2BP may useful to non-invasively observe liver fibrosis in patients with NAFLD.
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