Aim: We assessed the safety and effectiveness of drug-eluting beads transarterial chemoembolization (DEB TACE) with 5-fluorouracil (5FU) loaded HepaSphere for classical hepatocellular carcinoma (HCC). Regimen: A: 5FU 250 mg/5 m
l, non-ionic contrast medium (CM) 5 m
l, HepaSphere 25 mg, B: 5FU 400 mg/8 m
l, CM 2 m
l, HepaSphere 25 mg, C: 5FU 300 mg/6 m
l, CM 2 m
l, 10% NaCl 2 m
l, HepaSphere 25 mg, D: The regimen C is diluted from 10 times. Results: There was no CTCAE Grade 2-5 adverse reaction. The response (CR/PR/SD/PD, CR+PR rate) was as follows; A; 0/1/3/0, 25%, B; 0/1/5/0, 16.7%, C; 1/1/2/0, 50%, D; 1/2/3/0, 50%. Conclusion: DEB TACE with 5FU loaded HepaSphere for classical HCC is safe. It seems to be more favorable with well-tolerated and effective method uses 10% NaCl.
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