In order to facilitate the differentiation of the bacilli of secondary infection. from those of primary infection, streptomycin resistant tubercle bacilli were used in the superinfection.
Each group of guinea pigs was previously inoculated subcutaneously with 0.1 mg of lowly virulent tubercle bacilli, human type H37 strain, eight, four, three, two, one week, and immediately before secondary infection respectively, and all groups together with a control group were reinfected subcutaneously on the opposite side with 0.01 mg of streptomycin resistant tubercle bacilli, a virulent strain “Nakano” isolated from a patient.
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