THE diagnostic value of the hemagglutination test, as described by Middlebrook and Dubos, and modified by Kumagai, in human and experimental tuberculosis was discussed.
1. The sera of 150 patients with pulmonary tuberculosis and 50 normal persons were tested.
The tests were positive in 83.3 per cent of the tuberculous patients and in only 13.3 per cent of normal persons.
The positive rate was 51.2 per cent in minimal tuberculosis, 73.6 per cent in moderately advanced form and 100 per cent in far advanced form respectively.
The group of far advanced tuberculosis showed the highest positive rate. Any possibility of the cross reaction with Wassermann reaction was not recognized.
2. The hemagglutinin titer seemed indifferent from the intensity of tuberculin reaction.
3. In rabbits inoculated subcutaneously or intravenously, maximum hemagglutinin titer was observed during the period of from 20th to 30th day after the time of infection, followed by gradual decrease after that. Here also any parallelism between the hemagglutinin titer and the intensity of tuberculin reaction was not confirmed, but there was found a close relationship between the former and the hemobacteriostatio power measured by slide cell culture method.
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