Regional lymphnode of rabbits infected subcutaneously with bovine tubercle bacilli (dose 5 mg) were observed histologically and cytologically. Findings of the examination were as follows:
1. Intense exudation of polymorphonuclear leucocytes in lymphatic sinus was found in early stage, but it seems to be non-specific, because this change was not transformed to the tubercle formation or caseation.
2. Five days after inoculation we observed the epithelioidcell tubercle, which consists merely of some epithelioidcells, and has no other cells in inside. These tubercles are formed mostly in the peripheral part of the cortical parenchyma, especially near the medullar sinus. Infiltration of polymorphonuclear leucocytes in tubercles was found after tubercles were enlarged in later stage.
3. Reticulum cells of cortical parenchyma increase and swell and gradually show inclination to grouping. These concentrated reticulum cell groups show epithelioidcell-tubercle-like picture.
4. Nucreus of epithelioidcell has reticulum cellular character, and also there was recognized a transitional form between these two cells.
5. Some polymprphonuclear leucocytes which were observed in early stage show the increase of basophility of protoplasma and swelling of nucleus, then they become difficult to distinguish from rnonocytes.
The results of the present study indicate that first tubercles are formed in the peripheral part of cortical parenchyma near the medullar sinus, and that the formation of epithelioidcell tubercle has close relation to the increase of intraparenchymal reticulum cells.
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