巻号一覧
38 巻, 7 号
選択された号の論文の6件中1～6を表示しています
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I 反応の促進および増強と色調の変化小林 裕1963 年 38 巻 7 号 p. 253-258
発行日: 1963年
公開日: 2011/05/24
ジャーナル フリーTuberculin reaction was successively examined intracutaneously using 2, 000 times diluted old tuberculin 1, 3, 6, 12, 18, 24 and 30 months after BCG vaccination in school children. The tests were done in two sites simultaneously in each time: one test was given in the same site during the entire period of the experiment and the other was done always in a new site. The results were read after 24 and 48 hours.
1) On the repeated sites the reaction appeared and decreased its intensity faster than the new sites (accelerated reaction). Also the reaction was stronger in the repeated sites than in the new sites (augmented reaction).
2) Both a ccelerated and augmented reactions appeared at the first repetition in the same site and at the second repetition the grade of acceleration and augmentation became stronger than at the first repetition.
3) Tuberculin tests done in negative stadium do not influence the mode of the reaction after the acquisition of tuberculin allergy.
4) The reaction of which the color tone was not so fresh red as was formerly seen being either livid red, pale brown or only pigmented and so on, and the margin of the reacted area was difficult to distinguish from the unreacted area was named as “L” reaction. “L” reaction appeared markedly even, at the first repetition and then its appearance rate. greatly increased at the second repetition and more than 90 % of the reaction had “L” color tone. It may be said that “L” color tone appears just be foret he tuberculin reaction decreases and then disappears with the lapse of time, and in the repeated site it is observed as early as at 48 hours because the accelerated tuberculin reaction disappears faster.抄録全体を表示PDF形式でダウンロード (1118K) -
II 判定区分に及ぼす影響とその対策小林 裕1963 年 38 巻 7 号 p. 259-263
発行日: 1963年
公開日: 2011/05/24
ジャーナル フリーFollowing the previous report, the influence of the changes in tuberculin reaction caused by the repetition of testings in the same site, upon the practical determination of positive or negative was investigated.
1) In 48 hour readings, the positive rate in erythema was lower while the induration rate was higher in the new site than in the repeated site both by approximately 20 %, from the second repetition onward.
2) At the 48 hour readings the frequency of positive in the new site but negative or doubtful positive in the repeated site—the percentage of positive reactors who might be mistaken for negative by acceleration—was 1.4 to 4.8 %. On the other hand, the frequency of negative or doubtful positive in the new site but positive in the repeated site at both 24 and 48 hours was 7.9 to 24.3%, and this is considered to be caused by the weak tuberculin allergy which may not be detected in the new site by 2, 000 times diluted old tuberculin but appears positive by the augmentation in the repeated site.
3) In order to overcome these difficulties in the practical reading of tuberculin reactions caused by the above mentioned phenomenon, some authors recommend to change the injection sites every time and others advocate to carry out the reading after 24 hours instead of after 48 hours.
But, from the present author's results, it is difficult to change the exact site of injection in children during a long period as the length of the arm of the children extends by their growth. Concerning the 24 hour readings, although the failure of reading may become smaller at 24 hours than at 48hours in the repeated site, the mistake may be greater in the new sites in 24 hour readings as the negative cases at 24 hours but positive at 48 hours were about 10 % in the new site. And it is almost impossible to test in the repeated site exactly.
Therefore, the author proposes that the tuberculin test should be done in about the same site as possible every time and read at 48 hours carefullys; and, if possible, the 24 hour readings should be used as well. It is also advisable in cases of doubtful results to re-test in the new site.抄録全体を表示PDF形式でダウンロード (1010K) -
土持 隆彦1963 年 38 巻 7 号 p. 264-269
発行日: 1963年
公開日: 2011/05/24
ジャーナル フリーThe effect of ethio namide on the tubercle bacilli resistant to major antituberculosis drugs and of the other drugs on the ethionamide resistant bacilli were examined by following changes of the rates of resistant populations in the strains.
Six strains were used which had been isolated from the patients administered with antituberculosis drugs previously. Those strains were proved as partially resistant to one or more of isoniazid, streptomycin and PAS. Also the ethionamide resistant variant of H37Rv, strain was used which had been obtained by serial cultivations in liquid media containing ethionamide.
Dubos' media without and with O.5γ of ethionamide per ml or other antituberculosis drugs in the subinhibitory concentrations were inoculated w: th these strains and incubated at 37°C for a week. Before and after four to ten transfers every seventh day, the rates of drug resistant populations of each strain were examined by the cultivation on Ogawa's egg media containing different concentrations of the appropriate drugs.
The effect of ethionamide on population of the strains resistant to other antituberculosis drugs was as follows:
1) The rates of the high grade drug resistant individuals in the isoniazid resistant strains evidently decreased after the 4th and the 8th transfers in liquid media containing 0.5γ of ethionamide per ml.
2) The difference between decreases of the strept omycin resistant populations by the transfers in media containing no drug and of those containing ethionamide was significant.
3) The same result as above was obtained with PAS resistant strains.
4) With the double resistant strain to streptomycin and isoniazid, the decrease of resistant population was detected at the same rate after the transfers both in media with and without ethionamide. The effects of antituberculosis drugs on ethionamide resistant strain were as follows:
1) The rate of bacterial population of the ethionamide resistant strain was unchanged even after eight transfers in media containing no drug and containing the appropriate drugs at concentrations of O.01γ of isoniazid per ml, of O.5γ of streptomycin per ml, of O.1γ of PAS per ml, of O.5γ of kanamycin per ml, of 250γ of pyrazinamide per ml and of 2.5γ of cycloseline per ml.
2) With the mixed strain which was composed of ethionamide resistant variant and original sensitive strain of H37Rv in a ratio of three to seven, the complete loss of the populations resistant to 50γ/ml and 100γ/ml of ethionamide was observed a fter four transfers even in the media without drugs.
In summary, the populations resistant to isoniazid, streptomycin or PAS in the strains of tubercle bacilli were more susceptible to ethionamide than the sensitive ones.
The difference of susceptibility to the above various antituberculosis drugs was not significant between the ethionamide resistant and the ethionamide sensitive populations.抄録全体を表示PDF形式でダウンロード (1226K) -
戸井田 一郎1963 年 38 巻 7 号 p. 270-274
発行日: 1963年
公開日: 2011/05/24
ジャーナル フリーInduced formation of hydrazidase (hydrazides hydrolase)by Mycobacterium avium (Strain AVT) was repressed by asparagine in the medium, when induction was carried out with cells growing on the Sauton medium. The repression of hydrazidaseinduction was not specific for asparagine, but some of amino acids (Table 6), amides (Table 7), hydrazine and ammonia (Table 8) also repressed the induction. Therefrom, the mechanism of the repression by asparagine and other nitrogen containing compounds was postulated to be due to ammonia produced from these compounds by the bactreia.抄録全体を表示PDF形式でダウンロード (1018K) -
下出 久雄, 豊原 希一1963 年 38 巻 7 号 p. 275-279
発行日: 1963年
公開日: 2011/05/24
ジャーナル フリーIn our previous experiments, it was found that the virulence of INH-resistant catalase negative tubercle bacilli for guinea pigs varied with different infection routes, and that the pathological changes of the lungs were severer in the airborne infection than in the intravenous infection. The purpose of the present study is to examine the cause of this difference in the virulence between the airborne and intravenous infections.抄録全体を表示PDF形式でダウンロード (1080K) -
第1報 沖永良部島における結核前田 道明, 荒川 巌, 小林 茂信, 室橋 豊穂, 高井 鐐二, 柚木 角正, 宮崎 武人, 西園 実, 松元 光幸1963 年 38 巻 7 号 p. 280-286
発行日: 1963年
公開日: 2011/05/24
ジャーナル フリーPrevalence of tuberculosis was investigated on 23, 217 inhabitants of Okierabu-island in October 1961, employing tuberculin testing, chest X-ray examination and the bacteriological examination of laryngeal swab in the cases having abnormal findings in X-ray films. This island is located in the southern part of Tokunoshima island, where the tuberculosis mass survey was done in 1960. The results obtained were as follows:
1) The number of females was greater than that of males. The population in the age-group of 1629 years old was markedly less than that of the average figures in Japan.
2) The rate of re sponse was 98.6 % to the total inhabitants. The majority of the unexamined people was in travel outside of this island.
3) The positive rate of tuberculin reaction was 59.0 % which was higher than that of Tokunoshima Town. The positive rate of tuberculin reaction by sex and age group were almost similar to the figures obtained in Tokunoshima Town. Annual rate of positive conversion of tuberculin reaction due to natural infection was estimated at 1.2 % on the average.
4) Tuberculin reaction was tested employing PPD-s in a concentration of O.05 mcg per 0.1 ml. Among positive reactors, reactions with double erythema were found in 38.9 % and strong reactions with vesicle, necrosis or lymphangitis etc. were found in 5.9 %.
5) The nu mber of persons showing tuberculous changes on chest films was 2, 765, i. e.12.3 % to all examinees, 12.0 % in male and 12.5 % in female. Total number of morbid (active and inactive tuberculosis) cases was 725 (3.2 %), 3.9 % in male and 2.6 % in female. And the active cases indicated medical treatments were 514 (2.3 %), 2.8 %in male and 1.8% in female. These figures were higher than those of Tokunosima Town, but lower than the average fiegures of Japan. The rate of cavitary cases was 0.4 % to the total examinees, which was similar to the average of Japan and a little higher than that of Tokunoshima Town.
6) Okierabu-island was divided into two towns, Wadomari and China. In China Town, the positive rate of tuberculin reaction, the rate of strong reaction among positive reactors as well as the prevalence of cavitary tuberculosis cases were higher than those in Wadomari Town, and this can be explained by the fact that the tuberculosis control programme has been conducted more intensively in the latter than in the former.抄録全体を表示PDF形式でダウンロード (1279K)
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