The influence of the background factors on the negative conversion of bacilli and the incidence of drug resistance during the course of chemotherapy were analyzed by multiple factor analysis.
Three hundred and fifty-six (694 regimens) of already treated tuberculosis patients who were subjected to the treatment for more than six months with at least one of the following four secondary anti-tuberculosis drugs for the first time were adopted in this study: kamamycin (KM), ethionamide (TH), cycloserine (CS) and ethambutol (EB). The critical concentration of drug resistance in each drug was as follows: 10 μg/m
l for KM, 25 μg/m
l for TH, 20 μg/m
l for CS and 5 μg/m
l for EB.
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