巻号一覧
45 巻, 7 号
選択された号の論文の6件中1～6を表示しています
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束村 道雄, 水野 松司, 外山 春雄1970 年 45 巻 7 号 p. 195-197
発行日: 1970/07/15
公開日: 2011/05/24
ジャーナル フリーIn the course of the co-operative study with thirteen National Sanatoria on the infection of atypical mycobacteria, 277 strains of mycobacteria received from various hospitals were identified as Mycobacterium intracellulare.
Among these strains of M. intracellulare, 15 strains (5.4%) showed very dysgonic growth on the Ogawa egg medium as well as on the Sauton agar. In contrast to the other strains of M. intracellulare that showed good growth on a modified Sauton agar, in which sodium glutamate was substituted for asparagine, these 15 strains showed no growth or, if any, very scant growth on the Sauton agar.
Unlike the other strains of M. intracellulare, these slowly growing strains were unable to grow on synthetic media containing various nitrogen compounds as the sole source of nitrogen. The growth of these slowly growing strains of M. intracellulare was enhanced greatly by addition of Tween 80 (final concentration of 1%) to the Sauton agar.抄録全体を表示PDF形式でダウンロード (287K) -
合田 忠, 辰川 勇1970 年 45 巻 7 号 p. 199-205
発行日: 1970/07/15
公開日: 2011/05/24
ジャーナル フリーThree hundred and eight strains of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis were inoculated on nutrient agar. The tests were performed four times. The proportion of positive cultures ranged from 13.6 to 30.1%. The development of colonies on the medium was not consistent even in materials successively obtained from the same patient; sometimes it was observed and sometimes not.
The thirteen strains grown on the nutrient aga r were subcultured on the same medium every thirty days, and four of them were subcultured up to the 30th generation. The biological properties of these four strains were compared with those of the original ones.
No significant differences were observed on niacin production, nitrate re d uction, peroxidase activity, neutral-red reaction, methyleneblue reduction, acid-fastness in boiling water, catalase activity and acid-formation from carbohydrates and organic acids. The degree of growth on nutrient agar was not promoted during subcultures. It is notable that the ability of cord formation of agar-subcultured strains was lost.
The pathogenicity of three of the four strains to mouse showed marked decrease after agar-subcultures.抄録全体を表示PDF形式でダウンロード (774K) -
井上 豊治, 和知 勤1970 年 45 巻 7 号 p. 207-211
発行日: 1970/07/15
公開日: 2011/05/24
ジャーナル フリーAs to the origin of the accumulated fat in liver of ethionamide (TH)-administered rat, an extrahepatic factor was investigated.
1. Comparing the e p ididymal adipose tissue of normal rat with that of TH-administered one in their fatty acid composition of total lipid, there was no remarkable difference in the proportion of each fatty acid to the total.
2. TH-induced fatty liver demon s trated an intermediate pattern between normal liver and normal epididymal adipose tissue in the fatty acid composition of total lipid.
3. The administration of TH resulted no remarkable change of serum free fatty acid content in rat 6 hours later, however, it caused an increase of nearly twofold to the control 12 hours later, which was recovered 24 hours later.
4. In carbon tetrachloride-administered rat, on the other hand, the content of serum free fatty acid showed a continuous increase from 6 hours after the administration and it reached more than twofold of that in the control rat 24 hours later.
From these results, apart from any other factors, it is quite probable that in TH-administered rat as well as in carbon tetrachloride-administered one, the accumulated fat in liver was transported from the adipose tissue through circulatory flow.抄録全体を表示PDF形式でダウンロード (611K) -
東 義國, 森 亨1970 年 45 巻 7 号 p. 213-218
発行日: 1970/07/15
公開日: 2011/05/24
ジャーナル フリーThe distribution by size of tuberculin reactions was studied in previously BCG-vaccinated school children by three tuberculin examinations successively made with one year interval without giving re-vaccinations, to find that the distribution was always unimodal and symmetric, to be approximated by a normal distribution, and that each fraction of the distribution showed again a normal distribution in the next examination, spreading its skirts far beyond its initial range of size, reflecting a fairly large fluctuation of each individual's reaction size.
It is concluded from the findings that, tallying with findings reported from the WHO, the classification of tuberculin reactions by size into “positive” and “negative” cannot logically be applied in BCG-vaccinated populations, and that the post-vaccination allergy level is expressed best, not by the “positive conversion rate”, but by the mean size and the standard deviation, indicating the overall distribution of tuberculin reactions. Considering the duration of BCG vaccination effect expressed by the tuberculin allergy level, which must be much longer than used to be estimated before by accumulating the number of “negative reverters”, and also the illogicality of the present screening method for revaccination by the “positive”-“negative” classification of tuberculin reactions, a need for re-examining the method and the necessity of the BCG re-vaccination is stressed.抄録全体を表示PDF形式でダウンロード (609K) -
国立療養所化学療法共同研究班1970 年 45 巻 7 号 p. 219-226
発行日: 1970/07/15
公開日: 2011/05/24
ジャーナル フリー450 pulmonary tuberculosis patients were allocated at random to the following two kinds of regimens:
1 g of SM and 2 g of KM (Kanamycin) were administered twice weekly, while O.3 g of INH, 10g of PAS, 1 g of EB (Ethambutol), 0.5 g of TH (Ethionamide) and 0.5 g of CS (Cycloserine)were administered daily.
If sputum was p ositive at 4 or 5 months, SHP was switched to the combination of KM, TH, CS and EB at 7 months and SHPE to the combination of KM, TH and CS.
After excluding the subjects who failed to meet the criterion for accepta n ce to the trial or dropped out in the first two months of therapy, 148 SHP cases and 140 SHPE cases were analysed for clinical efficacy, while all 450 cases were utilized in discussing toxicity.
The rate of sputum conversion at 6 months was 94.9% in SHP and 96.9% in SHPE. The rate for far advanced cases was 91.2% and 94.2%, respectively. In the 7th series of our study, the superiority of the combined regimen of SM, INH, PAS and PZA over the ordinary triple drug regimen was established. The difference between PZA and EB in enhancing clinical efficacey of triple drug regimen, is not easy to understand, as EB is believed to be more potent than PZA. Simultaneous comparison is a necessary prerequisite for determining the relative merits of different regimens.
A planned and e a rly switching to entirely new regimen consisting of secondary drugs in. original treatment results in 100% conversion at the end of 12 months.
As the frequency of adverse reaction and especially the inc i d ence of drop out due to side effect are greater in SHPE than SHP, it seems reasonable to start the initial treatment with ordinary triple drug regimen and later switch to the combination of secondary drugs whenever necessary.抄録全体を表示PDF形式でダウンロード (896K) -
結核療法研究協議会1970 年 45 巻 7 号 p. 227-235
発行日: 1970/07/15
公開日: 2011/05/24
ジャーナル フリーThe Tuberculosis Research Committee, Ryoken, Japan, investigated the therapeutic effect of Rifampicin (RFP) on re-treatment cases of pulmonary tuberculosis. Patients who failed to convert to negative in spite of the long-term treatment with primary and secondary drugs and whose sputa were continuously positive for 3 months, were subjected to this study.
Cases were divided into the following two groups.
Group I: Patients who had been treated pre v iously with Ethambutol (EB). The previous regimen applied before this study was continued with the addition of RFP.
Group II: Patients who have not been treated with EB previously. Cases in this group were subdivided into the following two groups at random.
Group II A: Treated with RFP daily and EB d a ily.
Group II B: Treated with RFP twice weekly and EB daily.
The dose of RFP was 450 mg per day and that of EB was 750 mg per day.
Of 358 patients submitted to the study, 105 have been excluded from the analysis on account of pretreatment impertinent conditions or dropped-out, and the number of cases remained in each group was 121 in group I, 67 in group II A, and 65 in group II B. The results of treatment up to six months were analyzed in these patients.
The rate of sputum conversion was 57.3% in group I, 73.8% in group II A, and 79.4%in group II B at three months, 50.4%, 82.5% and 84.5%, respectively, at six months. It is noteworthy that over 80% of the re-treatment cases can be converted to negative after six months treatment with the combination of RFP and EB.
These patients treated with RFP showed no seri o us side effects, except gastrointestinal disturbances. In group I and II A which were treated with RFP daily, the incidence rate of gastrointestinal disturbances was higher than in group II B with twice weekly use of RFP.
It is interesting that the regimen with RFP twice weekly and EB daily showed ex c ellent therapeutic effect with less side effects.抄録全体を表示PDF形式でダウンロード (888K)
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