巻号一覧
46 巻, 11 号
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第2報重症多剤耐性例に対する成績全国自治体病院協議会結核部会ＲＦＰ共同研究班1971 年 46 巻 11 号 p. 423-428
発行日: 1971年
公開日: 2011/05/24
ジャーナル フリーThe therapeutic effects of Rifampicin RFP, on 31 re-treatment cases of chronic pulmonary tuberculosis with sclerotic walled cavities and drug resistance were investigated. All cases showed conIinuous pcsitive tubercle bacilli in sputum in spite of long term treatment with conventional primary and secondary antituberculous drugs. About 80 % of patients were classified as far advanced by NTA classification.
RFP was used in combination wit previously unused drugs or less resistant drugs.450mg of RFP were given orally once daily before breakfast or in 3 divided dose after each meal for 6 months. The rate of sputum conversion was 35.5 %, 58.6 and 63.0% at 2, 4 and 6months. on smear and 45.2 %, 48.3%, and 57.1 % on culture, respectively. The better results were obtained by the combination of RFP, EB and INH.
The improvement of chest X ray fndirgs was slight during 6 months treatment, as the majority of patients were of fibrocaseous or far advanced mixed type.
Clinical signs and symptoms became, in general, slightly b e tter under RFP treatment. No serious side effects were observed except one patient who showeri high fever with diarrhea at 4 months. Incidence of resistant strains to RFP was higher in these cases than in the previous: reported original cases. No improvement of the disease was expected when the tubercle became resistant to 10 mcg/ml RFP.
It is concluded that RFP is eective, to some extent, for the previously treated chronic pulmonary tuberculosis patients. especially when RFP is combined with other sensitive antituberculous drugs. for instance, etharnbutol.抄録全体を表示PDF形式でダウンロード (1104K) -
馬場 治賢, 高橋 竜之助, 吾妻 洋1971 年 46 巻 11 号 p. 429-435
発行日: 1971年
公開日: 2011/05/24
ジャーナル フリーSince May 1969, 87 severe cavitary pulmonary tuberculosis with persistent itive bacilli were treated with Rif-tipicin RFP. All the cases had already been treated with primary as well as secondarys for many years without success and had become resistant to these drugs. The present report is a result of 6 months RFP treatment. and 8 cases were excluded from the study due to various reasons. The remaining 79 cases were divided into the follwing 3 groups:
Group I: REP alon e or with resistant
Group II: RFP with one sensi tive drug.
Group III RFP with two sensitive drugs.抄録全体を表示PDF形式でダウンロード (1634K) -
阮 秋栄, 安野 博, 宮本 洋寿, 塩沢 正俊, 井村 价雄, 渡部 哲也1971 年 46 巻 11 号 p. 437-445
発行日: 1971年
公開日: 2011/05/24
ジャーナル フリーRelationship between pulmonary function and radiological findings was investigated in 53cases of pulmonary tuberculosis receiving pneumonectomy. The cases were classified radiologically into the following 4 types according to the grade of overdistension of lung; none (0), slight (I), moderate (II) and marked (III).
The proportion of patients with typ e III was higher among younger cases than among the older cases, and the fact indicates the good distensibility of the lung in younger patients.
Regardless of the grade of overdistension of the remaining lung, neither the vital capacity nor the total lung capacity showed increase after the operation. The residual volume in relation to the total lung capacity also revealed no significant difference according to the grade of overdistension. These facts show that the distension of the remaining lung is merely the morphological displacement of a part of the lung into the pneumonectomized space and is not accompanied with the increase in pulmonary function.
It was found that the alveolar ventilation was abnormally uneven in overdistended lung. In such lung, the volume of poorly ventilated area showed increase and the ventilation per unit of alveolar volume showed decrease, thus resulting in the definite arterial desaturatio n in some cases. The grade of such abnormalities, however, was less than that in chronic obstructive lung diseases. The arterial oxygen saturation was less than 92% in 2 of the study cases, and they were accompanied with either chronic obstructive emphysema or chronic bronchitis, which were presumed to be existing before operation.
No correlation was found between the grade of overd istension of the lung and the occurence of postoperative dyspnea.
In the majority of the cases, the arterial desaturation was improved after the resection of the diseased lung. The fact might be explained by the removal of venous admixture which existed in the resected lung.抄録全体を表示PDF形式でダウンロード (3021K) -
下方 薫, 真野 行生, 中村 宏雄, 山本 正彦1971 年 46 巻 11 号 p. 447-450
発行日: 1971年
公開日: 2011/05/24
ジャーナル フリーClinical analysis was made on 12 cases of tuberculous meningitis which have been experienced since 1962.
The diagnosis o f tuberculous meningitis was made by autopsy in 5 cases, by the presence of tubercle bacilli in cerebrospinal fluid in 3 cases, and by the typical symptoms and signs in 4 cases.
Four patients were male and eight were female. As to the age, only one case was oneyearold, one case from 10 to 19, 6 cases from 20 to 39, 2 cases from 40 to 59, and 2 cases more than 60.
The previous history of tuberculosis was found in 5 cases; among them, 3 had previous tuberculosis 1 to 4 years before the onset of tuberculous meningitis, and in the other 2 cases the date of previous tuberculosis was unclear.
Miliary tuberculosis was complicate d in 7 cases, pulmonaly tuberculosis in 3 cases, retinochorioiditis in 1 case, and renal tuberculosis in 1 case.
Body temperature ranged 38.0°C to 38.9°C in 7, 39.0°C to 39.9°C in 4, and 40.0°C or over in 1. Headache was complained of in 9 out of 10 cases with clear consciousness, and nausea and/or vomiting in 3 cases. Central nerve system disturbance, convulsion and/or rigidity were observed in 5 cases.
The cerebrospinal fluid findings in our cases were typical in the majority of cases, and tubercle bacilli in cerebrospinal fluid were positive in 6 cases.
As to its pathogenesis, early dissemination was su g gested in only one case in which meningitis developed soon after primary tuberculosis, and late dissemination in 5 cases with previous history of tuberculosis before one year or more, and unclear in 6 cases.
All cases were treated with antituberculous drugs, and corticosteroid was used in 11cases.
The prognosis was good in 5 cases but 7 cases died. It was thought that the most imortant factor influencing the prognosis was the pretreatment degree of disturbance of the consciousness.
In conclusion, tuberculosis meningitis in recent years was seen mostly in adults, developed by late dissemination, and the prognosis was not so good.抄録全体を表示PDF形式でダウンロード (711K) -
1971 年 46 巻 11 号 p. 451-476
発行日: 1971年
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (7482K)
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