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Volume 46, Issue 4
Displaying 1-5 of 5 articles from this issue
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Part II. The Relation between Virulence in Guinea-pigs and Thiacetazone Sensitivity of Tubercle Bacilli Isolated from Previously Untreated Tuberculous ChildrenToshio OHSATO, Kenkichi TSUKAGOSHI, Hisako SHIMIZU1971 Volume 46 Issue 4 Pages 83-87
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSMany workers reported that the virulence in the guinea-pigs of tubercle bacilli from previously untreated tuberculous patients differs markedly in various countries. Some workers showed that South Indian strains demonstrated the low virulence in the guinea-pigs and the low virulence was related to thiacetazone resistance. The other reports showed the high virulence in the guinea-pigs and the low resistance for thiacetazone of East African strains. The high virulence and the high thiacetazone resistance of Hong Kong strains were also reported.
In part I, the authors reported the thiacetazone sensitivity of 40 strains isolated from previously untreated tuberculous children in Japan. This paper presents the virulence in the guinea-pigs and the thiacetazone sensitivity of 30 strains out of 40 strains used for the experiment in part I.
Six guinea-pigs w ere inoculated 0.1 mg each subcutaneously and autopsied at six weeks after the infection. The method for the preparation of bacillary suspension was described in part I.View full abstractDownload PDF (1351K) -
Part III. Cross Resistance between Thiacetazone and EthionamideToshio OHSATO, Kenkichi TSUKAGOSHI, Hisako SHIMIZU1971 Volume 46 Issue 4 Pages 89-92
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe cross resistance between thiacetazone and ethionamide was reported by rr. any workers. This paper presents the ethionamide sensitivity of Japanese strains isolated from prevusly untreated tuberculous children according to different thiacetazone MIC. The results cf in vitro experiment using thiacetazone resistant H37Rv and ethi, : narnicie resistant H37Rv were also reported.
The Dubos Tween Albumin culture of six strains which shcwed the different thiacetazone MIC- 0.25 mcg/ml MIC: No.3; 0.5 mcg/ml MIC: 8; 1 mcg/ml MIC: No.7; 2 mcg/ml MIC: No.10; 4 mcg/ml MIC: No.9; 8 mcg/ml MIC: No.6 were inoculated 10-3 mg and 10-5 mg o n ethionamide containing media -1'7?-; Ogawa's mela. The drug cc, neentrations of etl.. ionarrirl'e tested were 12.5, 25 and 50 mcg/ml.
The sensitivity fir thiacetazone and ethh, riarnicle of tha. cetazc, ne resistant H37Rv cr ethionamide resistant H37Rv was examined by using niedla. The baciary suspension was prepared by grinding the culture on 1% Ogayas media and by adding the sterile distilled water to get 1 mg/ml. The drug concentrations tested were as follows: thiacetaz.: 0. 1, 5, 10, 25, 50, 100, 250, 500 mcg/ml; ethionamide 0, 12.5, 25, 50, 100, 250, 500. 1, 000mcg/ml The inoculum size of test strains was 10-1, 10-3 and 105mg. The reading, of growth on the media was made at 3 and 4 weeks after the incculation.View full abstractDownload PDF (1137K) -
Michio TSUKAMURA, Shoji MIZUNO1971 Volume 46 Issue 4 Pages 93-98
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSGenus Gordona is a new genus very recently proposed. The genus shows an intermediate feature of characters between genus Mycobacterium and genus Nocardia (Table 1). Four organisms were isolated recently: rum sputa of patients Nvi h pulmonary dieae. The organisms had been considered as if they were mycobacteria because of their acid-fastness only slighly weaker than the 3cid-fastnes. s of mycobacteria, but, by other characteristics, were identif. ed as Gordona (Table 1). The organisms were regarded as a species and named as Gordona auranticca, sp. nov., as they showed rough, orange-coloured colonies. The other species of Gordona, G. bronchialis, G. rubra and G. terrae, showed rough reddish or pinkish colonie s in air. The species G. aurantiaca was more acid-fast than the other species and lacked an ability to reduce nitrate to mitrite. As to the other distinguishing characters, it showed the same characters as the other species (Table 1).View full abstractDownload PDF (1918K) -
Shoichi ENDO, Kunio AOKI1971 Volume 46 Issue 4 Pages 99-111
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIf it is possible to estimate the future epidemiological trends and features of tuberculosis and to evaluate tuberculosis control programmes in the past, it will be very helpful to select the most effective control programmes against tuberculosis and to establish the best way for eradication of tuberculosis.
We tried to resolve this problem by simulation analysis using the epidemetric model of tuberculosis.
Waaler constructed a beautiful mathematical model of tuberculosis by which it is possible to simulate a variety of epidemiological situations of tuberculosis and antituberculosis programmes. This model is so constructed technically that it lends itself to rapid solutions by computer.
Waaler model was modified to be able to input the parameters we have had, as s hown in Fig.1. The population has been divided into 6 groups, that is, i) Non-infected, ii) BCGprotected, iii) Infected <5 years, iv) Infected >5 years, Inactive and Healed cases, v) Active case with cavity, vi) Active case without cavity. The transfer events between each subgroup are indicated by inter-connecting arrows in Fig.1. Various parameters used in the model were determined and estimated from the available data such as the results of nation-wide tuberculosis prevalence surveys and their follow-up studies, and vital statistics in Japan. The results of several epidemiological studies on tuberculosis were referred.
All epidemiological flows over time take place simultaneously with the aging of the population quinquenially. It is programmed for an electronic computer, as flow chart and equations are shown in Fig.2 and Table 1.View full abstractDownload PDF (2735K) -
1971 Volume 46 Issue 4 Pages 113-115
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (477K)
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