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Volume 47, Issue 11
Displaying 1-5 of 5 articles from this issue
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Masakichi MOTOMIYA, Shumpei TAKEDA, Hideo ARAI, Atsunobu YOKOZAWA, Hir ...1972 Volume 47 Issue 11 Pages 387-392
Published: November 15, 1972
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSAttempts were made to detect nicotinic acid, nicotinamide and 3-pyridinemethanol by gasliquid chromatography analysis for the purpose of differentiating mycobacterial strains by quantitative estimation of the above three compounds. They could be detected without converting them into derivatives.
With a 3mm×2m coiled glass column containing 3% of SE-52 on Chromosorb W, AW, DMCS at 120°C (flame ionization detector), nicotinic acid was found at 4. 4 min, nicotinamide at 9. 2 min, 3-pyridinemethanol at 2. 4 min and P-nitrophenol as an internal standard at 13. 8 min of retention time.View full abstractDownload PDF (722K) -
Masahiko YAMAMOTO, Kiichiro ISOE, Hiroo NAKAMURA, Hisao HIROSE, Seiya ...1972 Volume 47 Issue 11 Pages 393-397
Published: November 15, 1972
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTwenty eight cases of advanced pulmonary tuberculosis converted to negative at the fourth, fifth and sixth month after the administration of RFP, 450mg once every day, were followed up for 24 months.
RFP was administered 450 mg once every day for the first six months and 450mg twice a week for the next six months. After one year RFP was given in a way as shown in table 1: RFP was not administered in 17 cases; 450 mg twice a week from the 13 th to 24 th month in 4, from the 13 th to 18 th in 2, from the 19 th to 24 th in 1, from the 20 th to 24 th in 1 and from the 22 nd to 24 th in 1 case; and 450 mg once every day from the 20th to 24th month in 1 and from the 21 st to 24 th in 1 case.
In 3 cases, previously unused two other sensitive drugs were given with RFP, in 17 cases 1 such drug was added, but in 8 cases no such drugs were available (table 1).
The background factors of 28 cases were as follows: male in 18 cases and female in 10 cases ; younger than 39 years of age in 7, between 40 and 59 in 13 and older than 60 in 8; moderately advanced in 7 and far advanced in 21; without cavity in 1, with nonsclerotic walled cavity in 1 and with sclerotic walled cavity in 26 cases.
Three cases were not followed up for 24 months because of death: one from hemoptysis at 16th month after institution of RFP, in which tubercle bacilli were consecutively negative for preceding 14 months before death, one from cor pulmonun at 11th month after starting RFP, in which tubercle bacilli were consecutively negative for preceding 10 months before death, and the third case from cor pulmonun at 15 th month after starting RFP in which tubercle bacilli were consecutively negative for preceding 13 months before death.
In 1 case tubercle bacilli became positive at 8 th month after initiation of RFP, and in 1 case bacilli became temporarily positive at 19 th month. In the remaining 24 cases negative bacilli continued up to 24 th month.
The proportion of negative cases at the 12 th, 18 th and 24 th months after administration of RFP was 96.3%, 96.0%, and 96.0%, respectively (table 2).View full abstractDownload PDF (561K) -
Masahiko YAMAMOTO, Masakazu AOKI, Shizuo OKADA, Hideo KAWABE, Nobuhiko ...1972 Volume 47 Issue 11 Pages 399-403
Published: November 15, 1972
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe effect of Rifampicin (RFP) on atypical mycobacterial diseases were observed in 2 casescaused by M. kansasii, 2 cases by M. scrofulaceum, and 29 cases by M. intracellulare.
RFP was administered orally in the dose of 450 mg once daily before breakfast for 6 months.
One of 2 cases caused by M. kansasii was female, 54 years of age, far advanced, and the other, male, 64 years of age, far advanced. One of 2 cases by M. scrofulaceum was male, 74 years of age, minimal, and the other, male, 59 years of age, moderately advanced. The background factors of 29 cases by M. intracellulare were as follows: male 23 cases, female 6 cases; older than 60 years of age 16, between 40 and 59 years of age 11, younger than 39 years of age 2; minimal 1, moderately advanced 22, far advanced 6 ; cases without cavity 1, with nonsclerotic walled cavity 1, with sclerotic walled cavity 27.
In 2 cases caused by M. kansasii, bacilli were converted to negative and slight improve ment of chest roentgenogram was observed in both cases after treatment with RFP.
In 2 cases by M. scrofulaceum, the therapeutic effects of RFP were not obtained.
In 29 cases by M. intracellulare, the percentage of positive bacilli in sputum before and after administration of RFP was as follows: 2 months before RFP treatment 77.7%, 1 month before 80.7%, and after starting RFP treatment, at 1 month 64.2%, at 2 months 53.8%, at 3 months 70.3%, at 4 months 77.7%, at 5 months 63.3% and at 6 months 73.0%. The change of chest roentgenogram after 6 months treatment was as follows: improved in 0, unchan ged in 25, and deteriorated in 3 cases. It was concluded that the effect of RFP on the atypical mycobacterial diseases caused by M. intracellulare was slight, and only transient negative conversion of bacilli was obtained in limited number of cases after one or two months adminis tration of RFP.
Side effects of RFP was noticed in 2 cases by M. intracellulare; namely, transient elevation of S-GOT in one case, and nausea in the other.View full abstractDownload PDF (607K) -
Jiichiro KOBAYASHI, Yoshiko USUI, Yoshiko KASHIWAGI, Tatsuko UMEMURA, ...1972 Volume 47 Issue 11 Pages 405-410
Published: November 15, 1972
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIt is an important problem in the control of tuberculosis patients to find out defaulters and let them back to the treatment. Nagata Health Center of Kobe City had a talk with the Medical Association of Nagata-ku, and started the communication memo on the therapeutic status of registered patients between the physicians and public health nurses.
Patients living and treated at the institutions in Nagata-ku were subjected to the study. A communication memo was prepared for each institution and includes the name list of patients, their address and therapeutic status in each month. By the end of each month, public health nurse delivers the memo to each physician, and after several days, she receive the memo from the physician showing the therapeutic status of each patient and necessary indications. If a defaulter is found out, a public health nurse in charge of the patient's residence make a home visit and give him a guidance to come back to treatment.
Therapeutic status, a number and effect of home visit were investigated on patients under treatment during the period from September 1970 to March 1971. Out of 1, 251 cases, 75% were under regular treatment, 9% were under irregular treatment or interrupted treatment, 14% with unstable therapeutic status and 3% other types. The average number of home visit for each case was 1.3. After a home visit, 23% of cases under irregular treatment or inter rupted treatment became to receive regular treatment. Out of whole home visit, 52% were made on patients under regular treatment to prevent the defaulters. By the end of August 1970, the proportion of cases under regular treatment was 76%, and it raised to 82% by the end of June 1971 after adopting the communication memo, the proportion of cases interrupted dropped from 20% to 14% during the same period.
After adopting this system, the human relation between physicians and public health nurses has been markedly improved. In the future, it is expected that physicians give guidance to prevent defaulters and public health nurses concentrate their efforts for defaulters and irregu larly treated patients. Medical treatment should be conducted through close cooperation of medical staff team consiting of a physician, nurse, public nurse, medicosocial case worker, phychiatric consultant, etc. In Japan, however, medical treatment is conducted mainly by a physician, and the contribution of paramedical staff is relatively few. It is hoped that physicians recognize the importance of cooperation of paramedical staff in the treatment of patients through such an activity as the communication memo.View full abstractDownload PDF (929K) -
1972 Volume 47 Issue 11 Pages 411-441
Published: November 15, 1972
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (6739K)
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