Chemotherapeutic effects of RFP alone, two-drug regimen of RFP·EEB and threedrug regimen of RFP·EEB·EINH to Mycobacterium tuberculosis H
37Rv were evaluated in vitro by changing the incubating temperature at 37°C, 25°C and 4°C.
Comparing the results obtained at 25°C and 4°C with thos e at 37°C, the chemotherapeutic effects were remarkably lowered in the latter even in the three-drug regimen and the development of drug-resistance to RFP was not observed in such an inadequate condition for the growth of tubercle bacilli.
According to these results, it seems almost impossible to intensify the antituberculosis chemotherapeutic effect under the thermal condition inadequate for the growth of tubercle bacilli
in vitro.
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