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Volume 48, Issue 3
Displaying 1-6 of 6 articles from this issue
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Tatsuichiro HASHIMOTO1973 Volume 48 Issue 3 Pages 51-59
Published: March 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe tuberculin reaction, classical form of delayed type hypersensitivity, is defined as an immunologically determined inflammatory response characterized mainly by delayed onset of the reaction and by a mononuclear cell infiltration at the reaction site. These two characteristics are analysed in this review in relation to the mechanism of manifestation of the tuberculin skin reaction.
Many evidences in the passive transfer of tuberculin sensitivity showed that the passive sensitization could be established without lag by injecting.intravenously the mononuclear cells from sensitized animals to normal in the absence of demonstrable serum antibody and that the immunologically competent cells would be sensitized lymphocyts transformed from thymus-dependent lymphocytes. After leaving the regional lymph nodes where they were produced, the sensitized cells start to circulate through the whole body to establish the over-all sensitization to tuberculin.
Further experiments in which passive transfer was combined with desensitization or with labelling of donor or recipient demonstrated that the circulating sensitized cells interacted directly with the tuberculin injected intradermally and remained there at the contact site, reaching in several hours (within 6 hours) the necessary numbers for elicitation of the skin reaction. This immunologically specific process hardly manifests a visible reaction. The majority of the infiltrating cells at the reaction site consists of non-specific mononuclear cells, with a small portion of specifically sensitized cells, even when the reaction reaches the maximal intensity. The non-specific cells play a major role for the visible expression of the reaction, coming almost entirely from an actively dividing cell population through the blood stream. Thus the tuberculin reaction consists of 2 steps, specific and non-specific.View full abstractDownload PDF (1697K) -
2. Studies on the Source of Infection in FamilyKohei KITAHARA1973 Volume 48 Issue 3 Pages 61-69
Published: March 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSMany studies to determine the source of infection of pulmonary tuberculosis were reported by using the primary drug resistance, and some cases which were caused likely by exogeneous reinfection were reported. To overcome difficulties in determining the source of infection, a trial was made by using the phage type of M. tuberculosis. The phage type of the strains isolated from patients with pulmonary tuberculosis in the same family was examined. Method of phage typing; About 0.5mg of semi-dried isolated strains in 0.5ml of saline and 3ml of RVA were poured over a plate of 20ml of solidified RVA medium. After incubation at 37°C for three days, 0.01ml of phage suspensions containing 1×104 and 1×103/ml were spotted. After additional incubation at 37°C for another 11 days, the degree of lysis was recorded. Final reading was classified as BK1 Type, D34'-Type and DX-Type.View full abstractDownload PDF (1465K) -
Liver and Serum Total Cholesterol in Ethionamide-administered RatsBunji INOUYE, Nobuo YOSHIMURA, Tsutomu WACHI1973 Volume 48 Issue 3 Pages 71-74
Published: March 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSSome experiments were supplemented concerning the factors of fatty liver development induced by the oral administration of ethionamide (2-ethyl-thioisonicotinamide) to rats.
1) The liver total cholesterol level showed an increase of approximately 30% at 24 hours after the administration of ethionamide (200 or 400mg per kg body weight).
2) On the other hand, the serum total cholesterol level fell remarkably after the administration of ethionamide: it showed a decrease of 34.1% at 24 hours after the administration of 200mg ethionamide per kg body weight, and a decrease of 45.4% in the case of 400mg ethionamide per kg body weight.
3) There was a similar tendency both in the liver and serum total cholesterol levels of carbon tetrachloride-administered rats.
4) There was no obvious change in the serum GOT activity., whereas the serum GPT was twice as active as that of the control after the administration of ethionamide (400mg per kg body weight).
5) In carbon tetrachloride-administered rats, both GOT and GPT activities increased excessively.
6) From the results mentioned above and also of previous papers, it is suggested that the lipoprotein synthesis in liver or the release of lipids from liver to plasma ma y be impared because of the injuries of hepatic cells in ethionamide-administered rats, and therefore these factors may have some influence on fatty liver development together with other factors.View full abstractDownload PDF (683K) -
Kiyoshi OTANI1973 Volume 48 Issue 3 Pages 75-88_4
Published: March 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn recent years, the number of patients with bone and joint tuberculosis has been fairly decreasing because of improved preventive measures, widespread use of antituberculous chemotherapy, and better surgical treatment.
In our Sanatorium which has been specialized in the treatment of bone and joint tuberculosis in Japan, however, there are still a lot of patients with bone and joint tuberculosis. The majority of these patients are hardly curable due to long-standing fistula with a large amount of pus discharge resulting from purulent mixed infection, severe pulmonary tuberculosis, severe kyphotic spinal deformity caused by spinal tuberculosis, and/or senile patients who are unable to conduct the radical operation for bone and joint tuberculosis because of age.View full abstractDownload PDF (8097K) -
Kakugoro KONDO, Akihiko KUZE, Masamichi USUI, Yoshio HARADA1973 Volume 48 Issue 3 Pages 89-95_3
Published: March 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (4398K) -
Takashi ARAI1973 Volume 48 Issue 3 Pages 97-104
Published: March 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe late results of the operation for the cases with. pulmonary tuberculosis operated upon during the 10 years' period from 1958 to 1967 were investigated and problems about recent surgical treatment were discussed. The material consisted of 1, 451 cases of pulmonary resection and 201 cases of thoracoplasty, and cases which were operated upon on both sides were excluded. The mode of operation was lobectomy in 50%, segmentectomy in 24%, thoracoplasty in 12%, pneumonectomy in 9%, and lobectomy combined with other resection in 5%.
The post-operative failures were seen in 179 cases. in pulmonary resection (12.4% of all resections), including 29 cases with bronchial fistula, 4 cases with empyema, 63 cases with radiological aggravation, 70 cases with positive tubercle bacilli in the sputum and 10 cases of operative or early death.View full abstractDownload PDF (1179K)
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