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Volume 49, Issue 5
Displaying 1-4 of 4 articles from this issue
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Relationship between Macrophage Migration Inhibition Phenomenon and Delayed Skin ReactionToshiya KINO1974 Volume 49 Issue 5 Pages 117-125
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSMany recent investigations support the hypothesis that the macrophage migration inhibitory phenomenon is an in vitro model of delayed hypersensitivity. The sensitized lymphocytes liberate the migration inhibitory factor by contact with the specific antigen.
The dynamic aspects of immunocompetent cells for delayed hyper s e nsitivity were studied, comparing the macrophage migration inhibitory phenomenon and the delayed skin reaction.
Guinea pigs were sensitized by 1 mg or 10 mg of heat-killed BCG in the form o f Freund's complete adjuvant. According to the difference of the site of sensitization, animals were divided into two groups. The first was sensitized by only one injection of antigen into the back of the neck and the second was injected separately into the hind footpads and the back of the neck.
Regardless of the dose of antigen and the site of sensitization, delayed cutaneous reactions were similarly and intensively induced. However, the macrophage migration inhibition by peritoneal exudate cells was noted only in the animals sensitized by the injection of antigen into the hind footpads and no inhibition by peritoneal exudate cells was observed in the animals injected into the back of the neck (Table 1, Table 2, Fig.1 and Fig.2), although the adequate number of lymphocytes were in the peritoneal exudate cells (Table 4 and 5). On the other hand, the migration of the alveolar cells from the animals sensitized into the back of the neck was apparently inhibited and its intensity was correlated to that of delayed cutaneous reaction (Table 7 and Fig.3).
It was inferred that by sensitization procedure cells localized in the regional lymphnodes are sensitized in delayed type and that these sensitized cells are deposited in two different places, the lung and the peritoneal cavity, depending on the site of sensitization. A skin reaction, however, can be uniformly induced by sensitized cells which come from the depositoryView full abstractDownload PDF (1985K) -
Daishiro HASEGAWA, Toyozo SAKURADA, Fusanosuke YAMASAKU, Juji WADA, Ha ...1974 Volume 49 Issue 5 Pages 127-131
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTuberactinomycin-N (TUM-N) is a new antituberculous antibiotic from the fermentation troth of Streptomyces griseoverticillatus var. tuberacticus N 6 -130 which was d iscovered in 1971. Chemically, TUM-N belongs to the group of basic peptide antibiotics, and some close relation in its chemical structure with viomycin (VM) and capreomycin is suggested.View full abstractDownload PDF (2821K) -
Fumihiko KITATANI, Shiro FUJIMOTO, Toshiko ASAHI, Jyoichi KONISHIIKE, ...1974 Volume 49 Issue 5 Pages 133-138
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA regimen using Rifampicin every other day might be one of the proper regimen of RFP treatment, if the lag time of tubercle bacilli, the incidence of side-effects and the cost of the drug are taken into consideration. The RFP every other day regimen was applied to 36 cases of severe pulmonary tuberculosis who failed to be cured by chemotherapy and showing resistance to almost all anti-tuberculous drugs except EB. RFP in a dose of 450 mg was given every other day 60 minutes before the breakfast, and EB in a dose of 750 mg was given daily after the breakfast.
After 6 months' treatment, tubercle bacilli in sputum converted to negative in 67% on culture. Among cases remained sputum positive, the emergence of RFP resistance was observed already 2 months after starting RFP treatment, and the majority of strains showed complete resistance to 50 mcg/ml RFP. Chest X-ray findings showed no changes in most of the cases.
Two cases dropped out from the treatment; one case soon after starting treatment d ue to eruption, and another case at 5th month by death due to encephalomalacia. As the side-effects, albuminuria was seen in 5 cases, thrombocytopenia in 2 cases, and the increase of eosinophiles in 5 cases, and all of them were transient. Slight increase of serum transaminase was seen in 8 cases, and the slight elevation of serum bilirubin in 5 cases. Eight cases complained gastrointestinal disturbances, but all of them were slight and RFP was not interrupted.
Summarizing the results mentioned above, a regimen using RFP every o t her day with EB daily could be evaluated as a effective and safe regimen.View full abstractDownload PDF (1002K) -
Michio TSUKAMURA, Hisao SHIMOIDE, Jiro SEGAWA, Nobuhiko KITA, Nobumits ...1974 Volume 49 Issue 5 Pages 139-145
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSClinical feature of lung disease due to M. intracellulare was observed in 64 patients hospitalized in 11 participant hospitals during the period from April 1971 to September 1972.View full abstractDownload PDF (1377K)
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